Global Health Chronicles

Dr. Gerald Schochetman

David J. Sencer CDC Museum, Global Health Chronicles
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0:56 - Background and education

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Partial Transcript: Could you tell us where you grew up and little bit about your early family life?

Segment Synopsis: Dr. Schochetman discusses his college years and how he transitioned from the private sector to CDC.

Keywords: AIDS laboratory; AIDS Task Force; Atlanta, Georgia; AZT [azidothymidine]; biochemistry; Brooklyn, New York; electrical engineering; immigrants; J. Curran; medical school; molecular biology; Montreal; Philadelphia, Pennsylvania; Thousand Oaks, California; W. Dowdle; Washington, D. C.

Subjects: AIDS [acquired immunodeficiency syndrome]; Amgen Inc.; California; Centers for Disease Control and Prevention [CDC]; City College of New York [CCNY]; City University of New York [CUNY]; FDA [Food and Drug Administration]; Fox Chase Cancer Center; Frederick Cancer Center; Igen Incorporated; McGill University; National Academy; reovirus; Roche; Ukraine; United State Government; University of Pennsylvania

10:27 - Laboratory environment at CDC

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Partial Transcript: What were the major areas of HIV laboratory work that they were involved in? Do you remember?

Segment Synopsis: Dr. Schochetman discusses how the CDC laboratories were involved in applied research dealing with the epidemic, developing tests to figuring out how to culture the virus and providing laboratory support to the epidemiologic investigations.

Keywords: antibody test; C. Ou; Dr. Charles Shepard Award; Family of Surveys; Florida dentist case; HIV Epidemiology Branch; HIV Testing Lab; HIV-positive mothers; infants; Laboratory Investigations Branch; M. Rogers; NAT test; nucleic acid-based test; PCR test; polymerase chain reaction [PCR]; San Francisco; T. Dondero

Subjects: California; CDC; Cetus; FDA; HIV [human immunodeficiency virus]; New England Journal of Medicine; NIH [National Institutes of Health]; pediatric AIDS; Science

15:13 - Diagnostic testing for HIV

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Partial Transcript: What types of tests were available? How good were they? What were their limitations?

Segment Synopsis: Dr. Schochetman describes the different diagnostics tests used for HIV, the evolution of testing, what each measured, how they differed.

Keywords: antibody test; C. Ou; Dr. Charles Shepard Award; Family of Surveys; Florida dentist case; HIV Epidemiology Branch; HIV-positive mothers; infants; M. Rogers; NAT test; nucleic acid-based test; PCR test; polymerase chain reaction [PCR]; San Francisco; T. Dondero

Subjects: California; Cetus; FDA; HIV [human immunodeficiency virus]; New England Journal of Medicine; pediatric AIDS; Science

31:06 - Synergy and collaboration

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Partial Transcript: So, I was just curious about what your experience was over the years, about teaming up with epidemiologists and vice versa, the epidemiologists teaming up with you?

Segment Synopsis: Dr. Schochetman explains the importance of the collaboration between laboratory and epidemiology when using new technology and the laboratory work on the "Family of Surveys" which examined the prevalence of infection in childbearing women.

Keywords: childbearing women; epidemiologists; Family of Surveys; metabolic disease testing

Subjects: Abbott; Africa; Asia; CDC; FDA; Global Surveillance Program; HIV; Latin America

39:32 - Training resource for laboratorians

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Partial Transcript: Did you go out and train in the field? How did that work?

Segment Synopsis: Dr. Schochetman explains how the detection of HIV-2 made it clear there were genetic variants of HIV that required would require modifications of current tests to detect these variants and how the Global Surveillance Program began.

Keywords: antibody assay; collaboration; Global Surveillance Program; Infectious Disease Diagnostics Group; PCR; subtypes; variants

Subjects: Abbott; Africa; Asia; CDC; Europe; FDA; HIV; HIV-1; HIV-2; Latin America; Thailand; United States

44:53 - Transmission studies

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Partial Transcript: So this Global Surveillance Program that you were doing in collaboration with Abbott while you were still at CDC –obviously, you’re collecting, you’re getting lots of specimens, you’re finding modifications, changes. Who then would be working to tweak the assays, if you will?

Segment Synopsis: Dr. Schochetman discusses how private labs and CDC worked together to do transmission studies to track transmission patterns and how they amplified the genetic sequence information of the virus using PCR

Keywords: Boston, Massachusetts; New York City, New York; PCR; phylogenetic analysis

Subjects: CDC; FDA; HIV

49:36 - Florida dental case

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Partial Transcript: The Florida dental investigation.

Segment Synopsis: Dr. Schochetman describes how using molecular epidemiology or phylogenetic analysis CDC labs were able to connect a Florida dentist with several of his patients who had been infected with HIV in the dental practice.

Keywords: dentist; developing technology; Epidemiology Branch; gay men; high-risk behavior; HIV infected; Los Alamos database; no identified risk factors; patient; phylogenetic analysis; prototypic case; risk groups; scientific community; sequencing

Subjects: AIDS; Annals of Internal Medicine; California; Florida Department of Health; HIV; Molecular Epidemiology; United States; University of Texas

58:53 - Laboratory work - private vs. federal

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Partial Transcript: What are some of the things that a CDC can do well that are harder for the corporate sector, and vice versa? Can you look back and sort of compare and contrast?

Segment Synopsis: Dr. Schochetman discusses the differences between working for the private sector versus federal government, how CDC’s laboratory response set a new precedent, and what are some lessons learned.

Keywords: development; epidemiology; evolving epidemic; FDA-approved; global distribution; manufacture; media coverage; private sector; product; public health; technology; unprecedented

Subjects: Abbott; CDC; FDA; HIV; NIH

63:42 - Importance of opportunity, history, and discovery

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Partial Transcript: How has that affected you personally or professionally? I mean the opportunity to work on HIV/AIDS?

Segment Synopsis: Dr. Schochetman shares explains how his training at CDC prepared him to work in the corporate sector, how corporations must align themselves with public health policy to be successful as well as the importance of creating this history project.

Keywords: Atlanta; business development; collaboration; colleagues; customer needs; domestically; epidemics; epidemiologic; globally; history project; laboratory; opportunity; protecting the public; public health; silos; strategic initiatives; training

Subjects: Abbott; Abbott Diagnostics; Africa; AIDS; Asia; CDC; corporate sector; Europe