Partial Transcript: Could you tell us where you grew up and about your early family life?
Segment Synopsis: Dr. De Cock talks about his education and some of the influences on his early career choices as well as his interest in liver diseases, hepatitis and the new phenomenon of AIDS.
Keywords: assistant professor; economics; faculty member; fellow; infectious disease; liver disease; medical school; military service; politics; tropical medicine degree; viral hepatitis
Subjects: AIDS [acquired immune deficiency syndrome]; America; Belgium; England; hepatology; Kenya; United Kingdom; University of Bristol; University of Nairobi; University of Southern California
Partial Transcript: What made you shift from clinical medicine and move towards public health?
Segment Synopsis: Dr. De Cock explains how he got introduced to the EIS program, and how he was assigned to a branch within CDC’s he had not considered but ended up to be an excellent fit.
Keywords: A. Redeker; H. Margolis; hemorrhagic fevers; J. Maynard; Special Pathogens branch
Subjects: AIDS; Brazil; California; CDC [Centers for Disease Control and Prevention]; EIS [Epidemic Intelligence Service]; HIV [human immunodeficiency virus]; NIH [National Institutes of Health]
Partial Transcript: You said that was --they actually had some studies that intersected with AIDS. Tell us a little bit about that first project.
Segment Synopsis: Dr. De Cock explains how he worked on a retrospective cohort study on blood samples collected in the 1976 Ebola outbreak in Zaire [now called the Democratic Republic of Congo] testing those samples for the HIV virus.
Keywords: Atlanta; Belgian nuns; D. Forthal; hemorrhagic fever group; J. Mann; J. McCormick; K. Johnson; Kinshasa; mission hospital; retrospective cohort study; seroconversion; special pathogens branch; Yambuku
Subjects: Central African Republic; Democratic Republic of Congo; Ebola; Flemish; HIV; Institute of Tropical Medicine Antwerp; New England Journal of Medicine; Projet SIDA; Zaire
Partial Transcript: Why was there felt a need to have a project set up in Cote d’Ivoire? What were the goals of the project?
Segment Synopsis: : Dr. De Cock explains how the Cote d’Ivoire AIDS project began, starting with the third International Conference on AIDS in Washington. Challenges they faced in-country, and the rapid pace at which the Abidjan lab became a well-recognized, important research site.
Keywords: A. Porter; Abidjan; abortion; AIDS conference in Washington, D.C.; American Embassy in Abidjan; Antwerp; Atlanta; blood supply; blood tests; demographer; Fort Collins, Colorado; French Colonial links; HIV prevalence; Infectious Diseases department; infrastructure; J. Curran; J. La Montagne; J. McCormick; K. Holmes; K. Western; Kinshasa; L. Montagnier; M. Essex; M. Laga; medical students; mortality rates; mortuaries; New York City; P. Ghys; P. Piot; Paris; political and civil disturbances; research site; San Francisco; sex workers; university hospital; W. Heyward; Washington, D. C.; yellow fever epidemic
Subjects: Africa; AIDS; Burkina Faso; Cape Verde; CDC; Cote d’Ivoire; Guinea; Guinea-Bissau; Harvard; HIV-1; HIV-2; Institute of Tropical Medicine in Antwerp; Lancet; lymphadenopathy-associated virus [LAV-2]; Nigeria; NIH; Projet RETRO-CI [Retrovirus Cote d’Ivoire Project]; Projet SIDA; Senegal; Treichville Hospital; West Africa; Zaire
Partial Transcript: You’re using the terms AIDS, and I think that can apply to both HIV-1 and 2.
Segment Synopsis: Dr. De Cock explains how the West African team differentiated between HIV-1 and HIV-2 and the difficulties of this serology and establishing mother-to-child transmission cohort studies.
Keywords: Abidjan; cholera beds; chronic diarrhea; G. Noble; H. Jaffe; Infectious Diseases unit; J. Curran; mother-to-child transmission; receding infection; room number 24; serology; synthetic peptide-based tests; wasting syndrome; Western blots
Subjects: Africa; AIDS; CD4 counts; HIV; West Africa
Partial Transcript: What were the factors that led to this escalation and some of the differences that you saw in men versus women?
Segment Synopsis: Dr. De Cock explains the discrepancy in HIV prevalence between men and women in Abidjan and the cultural factors influencing that prevalence as well as setting up a testing clinic.
Keywords: Abidjan; Antwerp; chiefs; condom; female sex workers; gay men; Ghanaian women; heterosexual; Kinshasa; Matonge area of Kinshasa; O. Koudou; risk group; testing; transmission; women from Ghana
Subjects: AIDS; Clinique de Confiance; Cote d’Ivoire; East Africa; Ghana; HIV; sex industry; STIs [sexually transmitted infections]
Partial Transcript: That was an area that really brought some fruitful findings. Can you tell us a little bit about that?
Segment Synopsis: Dr. De Cock explains how the team found the connection between tuberculosis and HIV, how finding these connections could help with prevention, control and training.
Keywords: antiretroviral therapy; autopsied; blood donors; co-trimoxazole therapy; epidemiology; HIV serology; hospitalized patients, STI patients, tuberculosis patients, pregnant women; Kinshasa; lung disease; pathologist; R. Bretton; S. Lucas; sentinel groups; training
Subjects: Africa; Belgium; England; National AIDS Program; Pneumocystis; tuberculosis; United Kingdom; United States
Partial Transcript: I was curious about some of the challenges of a case definition in a country with limited resources. Talk a little bit about surveillance.
Segment Synopsis: Dr. De Cock discusses sentinel surveillance, creating a case definition, and how RETRO-CI is still in existence today, although it has become a PEPFAR site has weathered through political disturbances.
Keywords: A. Greenberg; Atlanta; Bangui; case definitions; clinical case definition; co-trimoxazole study; Geneva; HIV testing; infrastructure; interventions; J. McCormick; Kinshasa; mother-to-child transmission; political and civil disturbance; pregnant women; prevention; S. Wiktor; sentinel surveillance in pregnant women; short-course AZT [azidothymidine]
Subjects: AIDS; CDC; Central African Republic; Clinton administration; Cote d’Ivoire; EIS; HIV; Life Initiative; PEPFAR [President’s Emergency Plan for AIDS Relief]; RETRO-CI; tuberculosis; UNICEF [United Nations Children’s Fund]; WHO [World Health Organization]
Partial Transcript: Just curious about when you reflect back on a career, what are your thoughts?
Segment Synopsis: Dr. De Cock concludes with his personal thoughts clinical medicine, the epidemic, his admiration for CDC, and his recent work on Ebola.
Keywords: ARVs [antiretroviral drugs]; clinical medicine; EIS officer; hemorrhagic fever; London; public health
Subjects: Ebola; late-stage HIV disease; RETRO-CI; West Africa; Western medicine