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The COVID-19 pandemic is one of the most severe public health crises the world has experienced in living memory. In fact, COVID-19 is the most significant and complex public health challenge the Centers for Disease Control and Prevention (CDC) has ever faced. This living archive aims to collect and record the methodology, experiences, emotions, and reflections of a wide array of CDC personnel, and provides access to documents and items surrounding the effects COVID-19, had on all spheres of our daily lives.