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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
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This is an interview with Mrs. Paula Foege about her experiences in the
West African Smallpox Eradication Project. The interview is being conducted
at the Centers for Disease Control and Prevention in Atlanta, Georgia, on
July 13, 2006. This is a part of the 40th anniversary reunion of the West
African Smallpox Eradication Project. The interviewer is Victoria Harden.

Harden:     Mrs. Foege, could we start by your telling me briefly about
           your childhood and pre-college education; growing up; and what
           influenced your thoughts about what you should do in life?
Foege:           I was born in Chicago, Illinois. My family moved when I
           was 4 years old to Los Gatos, California, and my early memories,
           then, are of that. It was a very simple time. My father was a
           salesman, and he traveled to San Francisco every Monday and came
           back every Friday. I just remember it as a quiet time with
           neighbors, and going to school, small schools. Then from there,
           we moved 3 different times in California, and ended up in Palo
           Alto, where I went to high school.
Harden:     Were there any particular people in your life-your mother,
           ministers, teachers-anybody who inspired you as to what you
           might want to be?
Foege:           I think my teachers very much inspired me. From my very
           first memories, I wanted to be a teacher. And back then, there
           weren't that many vocations that were actually available for
           women, but that was always my love and my goal. I love children.
           At a very early age, I would babysit and play school.
                 My mother was a stay-at-home mother and my very closest
           friend. Her parents were very influential. They had come from
           Norway. I had a friend who had 3 sisters. I would say I spent
           the majority of my time at her house.
Harden:     Tell me about going to college, and how you met your husband.
Foege:           Well, I went off to college. My grandfather was a
           minister, and we were involved in the Lutheran church. My older
           brother by 3 years went to a Lutheran college in Minnesota, and
           I decided I would like to do that also. But I didn't want to go
           to the same college that he did. We had taken a family vacation
           up to the Pacific Northwest, and I really just loved it. And so
           the Pacific Lutheran College was in Tacoma, and that's where I
           chose to go. It's surprising to me that I did that because I was
           a very shy child, and to make a complete break from home and
           family was not characteristic of me.
                 But I got on the airplane, took off by myself, got a taxi
           when I arrived, and went off to school, where I think 2 days
           later I met Bill [Foege]. And he stood out because he was so
           tall. He was a senior, I was a freshman, and was a prankster
           even then. We had been to some parties where you get to know
           other people, and he was not supposed to be there; the parties
           were for freshmen. And he was casing out the new girls coming in
           with the freshman class. And so I met him. I didn't actually
           meet him at that party, but he stood out. Later on that week,
           coming out from the cafeteria, he was with some of his friends,
           and they had bets going on. "I bet you can't date the first
           woman who comes out the door," and it happened to be me. And so
           I said no. I don't know why I did; I just said no, that I
           couldn't do that. And he kind of followed me home, and made
           friends with my roommate, and I finally did date him, then. And
           I was only 18 years old.
Harden:     Only 18. When did you-all marry?
Foege:           We married when I was 20, so 2 years later. Quite
           surprising to me, my parents said yes and had no objections.
           Bill had completed 1 year of medical school; I'd completed 2
           years of college. And so we married December 23 because it was
           the only day he could make it, and we moved up to Seattle. I
           finished my undergraduate degree in the University of Washington
           while he was going to medical school.
Harden:     Now, I have just talked with him, and he was telling me a
           little about your moving around. When he finished medical
           school, he came down here to do the EIS training at the CDC, and
           then you went to Boston for him to get a Master's of Public
           Health at Harvard. I believe you had a child at some point along
           the way. What was it like for you?
Foege:           Our son, David, was born when Bill was an EIS Officer in
           Denver. And those were very quiet years, very simple compared to
           now. I had taught, a year before David was born, and then
           decided I would like to stay home with the children, which I
           did. It was somewhat difficult moving around because it was hard
           to have sustained friendships. But with the children, that made
           it easy because I would meet other mothers with children the
           same age.
Harden:     At that point. Now, it shifted pretty dramatically, though,
           didn't it, when he went to Nigeria, and you all were living in a
           very small village. Tell me about living in a small village and
           having a toddler.
Foege:           Well, it was good I was young because we just stepped
           right into it and just accepted it. The people of the village
           were just so kind to us. We would go to a market and people
           would walk up to us and give us, you know, like sixpence. This
           was just amazing to me because they had nothing. We didn't have
           that much ourselves-we were missionaries at the time-but we did
           compared to the people of the village.
                 It was extremely hot. We had no electricity. And even in
           the cool season, the lowest temperature was probably 75° at
           night, and the humidity was very high. And we slept under
           mosquito nets, which was difficult because it was so hot.
Harden:     Where did you get your water?
Foege:           Oh, my goodness. We hired a young man, and that's all he
           did all day. He had two 5-gallon drums-or 10-gallon drums, I
           can't remember-one on each side of his bicycle. And he would
           bicycle out to the water hole and bring water back for us. And
           then it wasn't fit to drink; it wasn't even fit to wash in. And
           so we had a stove, which was propane, and it went all day long,
           boiling water. So not only was it hot to begin with, and high
           humidity to begin with, but also we had this added to the house
           all day long, as well.
Harden:     And I presume if you had to go get your water, you didn't have
           any sewage systems or indoor plumbing for toilets.
Foege:           No, no. No, there was an outhouse, and I did not use it.
           We had a special little potty situation set up in the house, and
           then we would deposit it out in the outhouse.
Harden:     How about your child?  What was it like having a baby?
Foege:           David was 2 at the time, and believe it or not, it wasn't
           difficult. He played with the children in the village. The
           reason we were living in the village was to try to learn the
           local language. And he taught them little sayings in English,
           something about a cereal. We had seen the advertisement on
           television before we came. We went out in the village 1 day, and
           all these little children were sitting on the ground, and they
           were going, "We want Cheerios," or something of that sort. So
           the children had no problems communicating with each other, as
           children do. They just played together.
Harden:     Were you lonely?
Foege:           Yes. Yes.
Harden:     Lonely for friends your own age?
Foege:           Yes, and lonely for family.
Harden:     And lonely for family.
Foege:           Yes. It was a situation in which we were together as a
           family all day long, so that was helpful. Bill and I would go to
           language lessons together. There were other missionaries in the
           area who didn't live in our village, but lived in other
           villages. So we would all get together for our language lessons,
           and that was helpful.
Harden:     Now, as the political situation started heating up, you and
           your son, I believe, moved to Lagos, and then Bill had to get
           out fairly suddenly.
Foege:           Yes, right.
Harden:     How worrisome is all this for you at this time?
Foege:           Well, while we were in Enugu, and people were so kind to
           us; it was not frightening. There was high sentiment against the
           English at that time, but not against Americans. So we felt
           quite comfortable. When we were evacuated, Bill was actually
           working for the smallpox program. He was on loan from the
           mission, so that we had made close friends, Dave and Joanne
           Thompson [David M. and Joan Thompson] and Paul and Mary
           Lichfield. The women and the children were all evacuated
           together. Bill describes-perhaps he did in his interview-how he
           watched the airplane. Every seat in the plane was taken up with
           a mother and a child or two, and so we were heavily weighted
           down. So he watched the airplane, like, slowly, slowly try to
           gather height. And then we were only in Lagos for a short period
           before we were evacuated to the States. So it was difficult
           leaving our husbands behind and not knowing exactly what was
           going to happen, exactly what was going on. I had faith that
           Bill would handle himself well, and I know he told you how he
           went back and forth between the two fighting areas.
Harden:     Yes. When you came back to the States, it was the summer of
           1967, if I am correct? And you all were delighted that you were
           coming back to civilization, only when you got to New York you
           found out it was having some problems. Do you want to tell me
           that story?
Foege:           I can't say how many women and children there were, I
           don't know, but a good many, probably 80. The pilot could only
           fly so many hours so we hopped from country to country, trying
           to find a second pilot, so that they could then take the long
           journey across the ocean. Once we had, our first stop was Puerto
           Rico, and we all had to get out of the plane. W all had to
           gather our luggage and go through customs. And by then, our
           nerves were pretty frayed. You know, children were crying,
           everybody was tired, and people were complaining, "Why do we
           have to do this?" and whatnot. At that time, we had two
           children. Our second son was born when we were in the States,
           but we had returned to Nigeria. So I have, you know, one child
           on my hip and another one, making sure he stays close to me, and
           gathering all our luggage and trying to get all our papers
           together and whatnot. Bill had already done much, much traveling
           around the world at this time, and my thought was, "Well, this
           is one place I've been that Bill hasn't been." So it was worth
           it.
                 When we arrived in New York, it was summertime and it was
           hot. And we were put up in a hotel in which the air-conditioning
           system was broken. But the heating system wasn't. And so it must
           have been like 100° in our hotel room. And then the next day, we
           all scattered out to our separate homes.
Harden:     I understand there was a problem with the bus. Was this the
           same trip?
Foege:           That was a different trip. I know it was because Bill was
           along. Did Bill tell you about that trip?
Harden:     Yes, he was telling me some about it. I thought I might hear it
           from your side, your perspective.
Foege:           Yes. Well, we arrived in, again, New York. And the bus
           that we were put on was not working properly. So they put us all
           on the bus, and they couldn't get the bus started, and so they
           asked the men to all get off the bus. So all the men got off the
           bus. Here, again, it was like 90° and probably midnight. And all
           the men, then, were to push the bus so it could get a jump-
           start. And we got on, and they went a ways, and the driver did
           not have enough gas in the bus. So the situation was, do you
           stop, or do you go? Do you stop and not be able to get the bus
           started again, or do you just go and run out of gas? And so, he
           finally decided he needed to stop for gas, and he filled up. And
           then they couldn't get the bus started again. They were trying
           to get us to our hotel so they sent out different cars and small
           buses to pick us up, and they said, "All the men go on this
           side, and all of the women and children go over here," and I was
           like, the way this trip has been going, I'm not being separated
           from my husband. So I think they took all the women, and all the
           men and me and the children went in another vehicle.
Harden:     They don't prepare you in college for this kind of thing, do
           they?
Foege:           No, they don't. No.
Harden:     After you came back here in Atlanta, then did you-all go back
           to Africa during the duration of the smallpox program?
Foege:           Well, we went back for the relief program. If I recall
           correctly, I don't think Bill was involved in smallpox at that
           point. I think he was just involved with the relief work.
Harden:     This was the survey of malnutrition?
Foege:           Yes. Right.
Harden:     And you and the children went with him?
Foege:           And we went with him. To me, an interesting point on that
           is that we started off in the village, with no electricity, no
           running water, under mosquito nets-a really fairly
           unsophisticated situation. And then we were in our village
           mission compound, where we had only running water. And then we
           moved to Enugu, and we lived in a very small flat. And then we
           had running water and electricity. We didn't have air-
           conditioning. Our salary was paid by the mission field, and not
           by CDC. And that was very nice. And then finally we moved to
           Lagos, where we were staying in somebody's apartment who was on
           leave. It was very luxurious for us. So we had very different
           living experiences in our two years in Nigeria.
Harden:     Did you have servants at any point? I know you did not
           originally.
Foege:           We did, originally. His name was Lawrence, and he did the
           cleaning and the washing. I did the cooking, but he did
           everything else. He was a wonderful young man. When he first met
           us, he thought we were brother and sister, and that we were just
           children, because we were so young at the time. So he was a dear
           man, and really, really special with our children.
Harden:     I understand that it's kind of difficult for Americans in many
           ways, when they come to Africa. Some people feel very unsettled
           about having all these servants; they don't feel like they
           deserve them. But other people feel like, "Gee, this is great.
           Why should I go home?" Did you see all of this?
Foege:           Well, I was so grateful for Lawrence to help me. I don't
           think I could have managed everything on my own the way it was.
           And then he came with us when we went to Enugu, so he was with
           us for just about 2 years. I was grateful for him, and I didn't
           feel embarrassed or guilty to have him working with us. He
           became like a member of our family, really. He was probably only
           about 5 years younger than we were at the time. Then he followed
           us to Enugu, so he worked there, too. I continued to do the
           cooking, which was no small feat because everything was made
           from scratch. And he baked the bread for me, but other than
           that, I did my own cooking. When we were in Lagos, we did not
           have servants. There was really no need for it. What was very
           difficult for me was re-entering the United States.
Harden:     Why? Why was that difficult?
Foege:           Well, I was preparing for the culture shock in going to
           Nigeria. But I don't think other than the loneliness, that we
           really suffered much from culture shock. I was not prepared for
           the culture shock in coming back to the United States, where
           everything is at your fingertips. Everything is really almost
           overwhelming, just bombards you.
                 In Africa, we had a nice, quiet life, and Bill worked
           hard. He traveled a good deal, and that was difficult for us as
           a family. But life was sweet, and slow, and people were very
           generous to us-with us, and to us. Very, very friendly. And I
           found in coming back, you don't just step right back into your
           old life. People have gone on, and it takes a while to fit
           yourself back in again.
Harden:     Did you find yourself impatient with people in the United
           States when they complained, for example?
Foege:           I suppose, yes. People at first had an interest in what
           our life was like, but they were soon, you know, back to. . .It
           was almost, you know, like a "sweep it under the rug" kind of
           attitude. And, of course, they had not had the experiences that
           we had, so, you know, you tell a few stories and then it's on to
           life as usual.
Harden:     How would you characterize the impact that these experiences
           had on your family and on yourself?
Foege:           It certainly made a difference in our lives. Our oldest
           son still remembers Africa, and the children had later
           experiences in India, so the two situations together made an
           even stronger impression. But our older son was 4 when we came
           back home, so that's still quite young. But he does remember a
           good deal. I would say it gave our children a tolerance for
           different styles of living, different religions, certainly the
           impact of poverty compared to what it's like in the United
           States. Empathy. Empathy for other people, definitely.
Harden:     Before we stop, is there anything else about this program that
           you would like to say?
Foege:           Well, the program was wonderful in many areas-in helping
           people, in discovering new ways to handle different health
           programs, in the people that we met, who were basically not
           people who were out for what is life going to give to me, but
           what can I give to others. And that had a big impact on all of
           us.
Harden:     It was an idealistic time, I perceive.
Foege:           It was. It definitely was. And it's so exciting to be here
           now and to see some of these people we haven't seen for 38
           years.
Harden:     And I thank you very much for talking with me.
Foege:           You're very welcome.
&lt;/pre&gt;</text>
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. William Foege about his activities in the
West African smallpox eradication project.  The interview is being
conducted July 13, 2006, at the Centers for Disease Control and Prevention.
 It is a part of the 40th anniversary celebration of the launching of the
West African smallpox eradication project.  The interviewer is Victoria
Harden.

Harden:     Dr. Foege, would you briefly describe your childhood and your
           pre-college education--who influenced you to go to medical
           school and get interested in public health?
Foege:           I started out in northeast Iowa, and lived in a small town
           of 100 people.  When my family moved away, the population went
           down eight percent.  I went to a one-room schoolhouse for the
           first five years.  We then moved to Chewelah, Washington, and I
           thought I was really in a big city.  It was about 1500 people.
Harden:     And why did you move?
Foege:           My father was a minister, and he got a call to a new
           church in Chewelah, Washington.  We moved for that reason.  From
           there, I went to Colville when he started a new church in
           Colville, and that's where I graduated from high school.  I went
           from high school to Pacific Lutheran [College], what is now
           Pacific Lutheran University, in Tacoma, Washington, and became
           interested in biology, because of a very forceful biology
           teacher who was a man I've never seen the likes of.
Harden:     What was his name?
Foege:           His name was William Strunk. In class, he would walk into
           the room, lecturing as he walked in.  He would go to the board
           and actually write with both hands simultaneously, putting up
           phyla and families and classes and genera.  He would still be
           talking as he left the room.  I was a lab assistant to him and
           also worked at his place on weekends, doing yardwork.  He played
           an important part in getting me into science.  My older sister,
           Grace, four years older, had gone to the same school, and she
           went to medical school.  She also was an influence.  I was also
           influenced as a fifteen-year-old when I spent three months in a
           body cast, unable to turn over or do anything.  That was in the
           days before television, so I was doing a lot of reading.  I
           began reading about Albert Schweitzer, and medicine, and Africa,
           and all of this became very interesting to me.
Harden:     Had you had an accident, or...?
Foege:           I had a problem with my hip that required three months of
           immobility.  The hope was that it would heal correctly, and it
           did, but the hip was always off a little bit.  This period was a
           time of reflection and reading that I might not have had without
           that physical problem.
                 In medical school, I began working after school and on
           Saturdays for a fellow by the name of Ray Ravenholt.  Ray
           Ravenholt had been one of the first EIS officers, Epidemic
           Intelligence Service officers, at CDC [Centers for Disease
           Control], and he was always pushing the idea of public health
           and also the idea that I should think about joining the EIS at
           CDC.  I went off to New York for my internship, and I had been
           accepted in an internal medicine residency, when I got a call
           from Don Millar [J. Donald Millar] at CDC.  He said they had
           just received some positions that enabled them to expand the EIS
           class, and would I be interested?  I abandoned my idea of going
           into internal medicine, and went to CDC in the EIS class of
           1962.
Harden:     Had you always been interested in public health, or was that
           just a sideline until you got to CDC?
Foege:           Ray Ravenholt was such a powerful influence on me that I
           was interested in public health by the time I graduated from
           medical school.  Of course, I didn't see exactly where I was
           going until Don Millar called with this EIS opening, but then I
           never looked back.  I was extremely pleased at CDC with the EIS
           program.
                 I was first assigned to Colorado, a state assignment, and
           while there I did two overseas TDYs [Temporary Duty].  One was
           to India, in 1963.  At an EIS conference, they had announced
           that the person holding the Peace Corps position in India had
           taken sick.  It was going to take some time to replace him, so
           they were looking for a volunteer to go as the Peace Corps
           physician.  This I did, and it turned out to be important in so
           many ways.  I saw global health close up.  I saw my first cases
           of smallpox.  I made rounds at Holy Family Hospital in New
           Delhi.
                 I worked for a man by the name of Charlie Houston, who was
           key in mountaineering.  In 1953, he had actually led a group up
           K2 [Karakoram 2 mountain in Pakistan], and before getting to the
           top they were stuck in a storm.  One person developed deep vein
           thrombosis in one leg and then developed it in the other leg.
           Charlie Houston said that they had to get him down, but everyone
           said, "We can't go down in a storm."  Houston said, "It's his
           only hope."  So they attempted to rescue him in a storm, and as
           they were descending across an ice field at a forty-five degree
           angle, one person slipped and fell.  This person got tangled up
           in another rope, and then four people were falling.  They hit
           Charlie Houston, who was on a third rope and knocked him
           unconscious.  The four people plus the three on Charlie
           Houston's rope were all falling, and they were held by a man by
           the name of Peter Schoening, who, with his ice axe, was able to
           stop all of them.  It's an incredible story, and to make it even
           more incredible, two months ago I went to the University of
           Colorado, where they gave Charlie Houston, at age 93, an
           honorary degree.  They had a half-day program giving him an
           honor. All of the survivors of that 1953 expedition were there,
           including Bob Bates at age 95, former headmaster at Exeter, and
           Bob Craig, the youngest of the group, who was now in his late
           80s.  Charlie Houston was spectacular person to work for.  He
           was able to demonstrate that you can work in a developing
           country and not get overwhelmed by it.  He always got up every
           morning just happy to be working and was never overwhelmed.
Harden:     I believe that you also were involved as an EIS officer with
           the group that went to Tonga to evaluate the smallpox vaccine,
           and the jet injector.  Would you talk about that?
Foege:           The other overseas TDY that I did was to Tonga, a group
           headed by Ron Roberto [Ronald R. Roberto].  The idea was to see
           could you dilute smallpox vaccine and use it in a jet injector.
           Tonga had not done routine vaccinations since 1905, so it
           provided a virgin population in which you could measure
           antibodies and so forth, and the Tongans were agreeable to
           having this study done.  We wanted to evaluate the effectiveness
           of different dilutions of smallpox vaccine--a one-to-ten, one-to-
           fifty, one-to-one hundred, and so forth.  It turned out to be a
           very good study that demonstrated you could dilute the vaccine
           one to fifty, and that you would still get uniform take rates.
           We also demonstrated that the vaccinations could be given with
           the jet injector, which didn't require special training in
           technique to have the vaccinations come out the same with every
           person.  It was easy to train a person to use a jet injector.
           This turned out to be a very important study.
Harden:     May I ask you to describe how the jet injector worked?  Did it
           actually touch the people's skin, and if so, did you have to
           sterilize it between uses?  I don't understand how you could do
           thousands a day, if you had to sterilize between every one.
Foege:           The jet injector nozzle actually did press up against the
           skin.  At that time, people were quite sure that there was no
           chance of cross-contamination, that the vaccine came out at high
           pressure, but we've subsequently changed our mind about this,
           and that's why we don't use jet injectors at this point.  But
           because we believed it completely safe at that time, one could
           actually do people almost as fast as they could walk by.  You
           set up a rhythm: grab the arm, step on the hydraulic lever,
           shoot, and the person would continue on.  You could do a
           thousand people an hour, and I remember at one point doing a
           prison in eastern Nigeria, where they had the inmates lined up,
           and they were actually pushing them through by hitting them with
           sticks.  I did 600 people in twenty minutes, because it was such
           a regimented line that you could just grab people and do them so
           fast.  At one point, I recall doing over 11,000 smallpox
           immunizations in one day.  So, yes, you could do this very
           quickly.
Harden:     Before we move on in your career, is there anything else that
           you would like to comment about in your EIS training here at the
           CDC?
Foege:           In those days at CDC, anyone in the EIS program saw Alex
           Langmuir [Alexander Langmuir] as a mentor.  He was a very
           powerful personality.  He knew what he was doing, he was
           inspired and inspiring.  And so I'd look back on those days as
           days where Alex Langmuir was reaffirming how important it was to
           do public health, and how important it was to do global health.
           He was interested in everything.
                 Also during that time as an EIS officer, I read an article
           in the New England Journal of Medicine.  It was called
           AQuestions of Priority,@ written by Tom Weller [Thomas H.
           Weller].  I had no idea at the time that Tom Weller was a Nobel
           laureate, but when I read the article, I knew I wanted to know
           him, because he was saying in the article things that I
           believed.  It was a commencement address to the Harvard Medical
           School, and he was essentially saying,
                  "You're only going through life once, you might as well
                 try to get it right, and here [at Harvard] you come out
                 with all these skills and this knowledge, and you have to
                 ask how you're going to use it.  Think about using it in
                 the parts of the world that can best use these resources.
                 The developing world doesn't have the resources of skills
                 and knowledge, and now that you've gone through, think
                 about using what youve learned in the developing world."
Harden:     Maybe I can digress here for one philosophical question.  The
           early 1960s were an idealistic time, in a variety of ways, and
           the idea that to get it right in life you went and served people
           is a very different idea from getting all you can for yourself.
           Would you comment on the idealism of your peers in this period?
Foege:           The early 1960s turned out to be a very nice time to be
           growing up in the United States.  President Kennedy inspired
           people with the idea of the Peace Corps.  People thought about
           how best to serve their country and how best to serve the world.
            So when I read an article by a Harvard professor saying the
           same thing, I decided that I wanted to get to know him.  I
           applied at Harvard, and no place else, and I spent a year with
           Tom Weller.
Harden:     As I understand, you did this on your own, rather than having
           the CDC sending you.  You received a Master's of Public Health
           degree.Foege:          That's right.  CDC actually offered a
           career development program to me, which meant that I could have
           training paid for for a number of years, and then I would pay
           back a certain number of years.  But by this time, I already
           knew I was going to Africa or someplace else in the developing
           world, and it didn't seem fair to have CDC pay for my education
           and then, even if I paid back a certain period of time, leave
           for another job.  So I went to Harvard on my own.  I did get a
           scholarship, but I went on my own, and it turned out to be
           everything that I had hoped it would be.  Tom Weller was an
           inspiring person.  He worked with an inspiring group of people,
           including Frank Neva [Franklin A. Neva], who was my faculty
           advisor.  Neva is the father-in-law of Peter D. Bell, who became
           president of CARE, and the father of Karen Bell, who ended up
           teaching here at Emory University in the School of Public
           Health.  And so it turned out to be a very nice experience.
           When Tom Weller retired from Harvard, it so happened that I gave
           the commencement address that year.  I got out that New England
           Journal of Medicine article, and I read the portions that I had
           found so attractive before, and made the point that you never
           know what will ripple downstream from what you say or what you
           write.  Well, Tom Weller got a standing ovation in the middle of
           my commencement address, and it completed a circle.  I've
           remained in contact with Tom Weller, who's in his 90s, just as I
           have with Charlie Houston and some of my other mentors.
Harden:     When you finished your training at Harvard, you joined a
           medical missionary program in the Lutheran church.  Apparently
           it took a bit of effort to convince them to let you do a public
           health mission, as opposed to a primary care mission.  Would you
           talk a bit about that, and what you finally set up?
Foege:           Let me mention one more thing about Harvard before going
           to that.  In one of Tom Weller's classes, we had to do an
           independent project and present it.  I happened to do a project
           on the feasibility of smallpox eradication in the world.  I had
           no idea that I would ever be involved in this, but I found it an
           intriguing topic.  There was a person in this group, Yeme
           Ademola, who was the head of preventive medicine for Nigeria.
           He had taken a year off to get a master's degree at Harvard, so
           Yeme and his wife Rosa were there, and he was part of that
           class.  After graduation, Yeme Ademola came down to CDC, and
           talked to people about his interest in smallpox eradication in
           Nigeria.  This is a small aside.
                 After graduation from Harvard, I went to Nigeria to work
           for a church group.  I knew that most of the hospital beds in
           Africa were provided by church groups, so they had a big
           influence on health in Africa.  But almost all of them were
           involved in clinics and hospitals, not in community work.  It's
           easy to see why that would happen, because church programs had
           found that medicine was a great proselytizing tool.  People in
           hospitals and clinics felt real gratitude, and so medicine
           turned out to be a form of recruitment.  I always felt that was
           wrong, I felt that churches should be working in Africa or other
           places because of what they believed, not because of what they
           were trying to get other people to believe.
                 I wondered what would happen if you could get this force
           looking at community medicine instead of hospital medicine.
           Community medicine takes a far different approach to things.  In
           the end, it made no difference that I actually went to Africa to
           try to make that change.  There were other things happening at
           the same time that would cause church groups to shift to
           community medicine.  The World Council of Churches had a
           Christian medical commission, and there was a fellow by the name
           of McGilvray [James C. McGilvray] who headed that up. He
           believed in community medicine.  He was so influential that, in
           a period of years, he got medical mission programs to change in
           three fundamental ways.  Number one, he got them to understand
           they had to work under governments.  Colonialism was over, and
           they had to work under sovereign governments.  Number two, he
           got them to work together.  They had been very competitive in
           the past.  In many countries there would be one person who was
           the coordinator for all Protestant work, and another one who was
           the coordinator for all Catholic work.  McGilvray's influence
           resulted in--at least, in a few countries--those two sitting in
           the same office. This was an incredible change.  Number three,
           he got them interested in community medicine.  So I could have
           saved my time.  I didn't prove anything by going over.  It was
           happening anyway.  But I did go over, and I was trying to
           promote community medicine.  I would probably have spent decades
           working on this, except that when the war in Nigeria came, it
           went through our medical compound within the first weeks.
Harden:     Would you back up and tell me exactly where you were, what was
           happening, and what you were doing when the war came?
Foege:           I graduated from Harvard in 1965, and that summer, we left
           for Nigeria.  We went to a medical center in the eastern part of
           Nigeria.  In those days, Nigeria did not have states.  It had
           only four regions.  The north, the east, the west, and the
           midwest.  We were in the eastern region.  This was the region
           that was dominated by Ibos, who would later form the Republic of
           Biafra.  We were in a minority area of the east, in a place
           called Ogoja province, up near the Cameroon border.  In this
           area, there was a medical center at a place called Yahe.  It was
           a crossroads town, and that's where we went.  We spent the first
           six months living in a village in order to learn the local
           language.  It was an eye-opener, because it was a village with
           no electricity, no running water, and no indoor bathrooms, that
           sort of thing.  We had an opportunity to see what life was like
           in a village.  We had a three-year-old son at the time.
Harden:     So you were married, with children, at this point?
Foege:           Yes.  I had a wife, Paula, who will be the next
           interviewee, and a three-year-old son, David, and we had the
           naive notion that we would actually know what it was like to
           live in a village.  There's actually no way to know that,
           because we could leave any time.  The people living there
           couldn't leave.  Living there was a form of bondage that I don't
           think it's possible for us to understand.  But we were trying
           to.  We lived in the village for six months and then moved to
           the medical compound.  While we were at the medical compound,
           CDC asked if I would spend time as a consultant for the smallpox
           eradication program.
Harden:     This was before or after the revolution?
Foege:           This was before the war broke out.  We had been in Nigeria
           for almost a year at the time that Henry Gelfand came to Enugu
           to ask me if I would be a consultant.   Our medical center was
           ninety miles from Enugu, the capital of the eastern region, but
           we agreed that for a period of one or two years, I would work as
           a consultant on smallpox eradication, and I would go back to the
           medical center on weekends.  I would try to do both things,
           ninety miles apart.  In 1966, Paula and I returned to CDC to
           take the summer course for the people who were first going out
           to Africa on the smallpox eradication work.  This is the group
           now meeting for a reunion.  It turned out to be a very nice time
           for us to be back, because my wife was pregnant, and she
           delivered our second child, a boy, in September.  It all worked
           out that we came back here, and she had the baby in Walla Walla,
           Washington, where my folks were living, and I attended the
           summer course and then met up with her.
                 Now, an interesting aside.  It takes a while to get a
           passport for a baby, to get a baby added to a passport.  I even
           contemplated taking a picture of any baby and getting this on
           the passport before ours was born, so that we could move more
           quickly.  I did not take that route, showing more sanity than
           usual.  We waited, and I returned to Nigeria.  Paula came over
           with the two children when the baby was about six weeks old.
Harden:     These are the small logistical problems, personal logistical
           problems that people  rarely think about.
Foege:           Sometimes they turn out to be overwhelming.  When I knew
           that I would be coming to the US for the summer course at CDC, I
           bought tickets for my wife and for David.  CDC would send the
           ticket for me.  We got to Lagos, ready to board the flight, but
           my ticket had not arrived from CDC.  I talked with the Pan-Am
           manager, and he said,  "You're in luck, because the plane is
           late by twenty-four hours.  We have more time to try to get the
           ticket."  But it was July fourth.  That meant nothing in
           Nigeria, but it meant we couldn't get anything out of CDC.  And
           so the next day, we went right down to the line with tickets for
           them but no ticket for me.  About an hour and a half before
           flight time, the manager called me in, and he said, "We haven't
           heard anything.  But I'll tell you what I'll do.  If you write
           out a check for the amount of the ticket, I'll put it in my desk
           drawer, and so I'm covered if I get audited."  I told him, "I
           can't do that.  I don't have that amount of money in my
           account."  We were at an impasse, but an hour before flight
           time, he said, "I'll tell you what I'm going to do, and I've
           never done this before.  I'm going to give you a ticket."  And
           he said, "I'm going to have to write out the check if I get
           audited."  He gave me a ticket, and we got in line.  But the
           airline representatives said, "This ticket was for yesterday."
           I said, "Of course it was.  The plane was supposed to be here
           yesterday."  Then I had to go back to the Pan-Am agent and say,
           "They won't take this ticket."  He was exasperated by that time,
           but he got us through.  We got on the plane finally, and at last
           I felt that we could relax.  I actually said to my wife, "Isn't
           it going to be nice to get back to the States, where things
           work?"
                 We got to New York.  It was hot, it was at night, and we
           were twenty-four hours late, so, of course, everyone had to have
           new connections.   My wife and son had a new connection, but I
           didn't, because I didn't actually have a ticket.  This caused a
           problem.  Pan Am said that they would put everyone up overnight
           and that we would all get out in the morning.  We stood in the
           heat, and even though we were coming from Nigeria, it struck me
           how hot it was in New York.  We were  waiting for the bus to
           take us to the motel, the traveler's motel.  There was a Pan-Am
           man there in a suit and a tie.  He was very efficient.  He
           picked me out and asked me to give them a hand.  And then he
           picked out another person, and I realized he picked us for our
           size.  He took us outside and said, "The battery's dead on the
           bus.  Would you help push it to get the bus started?"  And we
           did.  We pushed it fast enough to get the motor to turn over,
           and the engine caught.  Then he called for men to board first.
           I wondered why he did this, but the men, like sheep, got onto
           the bus.  It turned out that the back of the bus was very hot.
           He was saving the front of the bus for the women and children.
                 I heard him say to the bus driver, "Remember to stop at
           the first service station and put in three quarts of oil."  I
           thought, "Three quarts of oil.  This is a real problem."  The
           bus driver let out the clutch and killed the motor.  Everyone
           was told to stay on the bus, as hot as it was.  The Pan-Am man
           said that another bus was coming to push this one to get it
           started, and that's what happened.  And again he said to the bus
           driver, "Remember, three quarts of oil."  We went down the
           highway, and it must have been eleven or eleven-thirty at night
           by then.  He pulled off into a service station and sat there for
           a moment.  Then he turned around and said, "You know, folks, if
           I stop the engine to put in oil, we're not going to get it
           started again."  And so off he went onto the highway, and soon
           the motor froze up.  There we were, on the side of the road,
           with the motor frozen, and he told  everybody to get off the bus
           because it was too hot to stay on.  He made a phone call, and
           pretty soon this Pan-Am agent comes screaming up in a car, and
           by this time he had his tie off and his jacket off and he was
           starting to look disheveled.  He said, "Don't worry, we have
           some cars and another small bus coming."  When the cars and the
           small bus came, he told the women and children to get in the
           cars, and the men to get in the bus.  All the women and children
           did as they were told, except my wife, who stayed with me.  She
           said, "The way things are going tonight, I may never see my
           husband again, so I'm not moving."  Finally, we got on the bus
           and we get to the motel.  But to have said, AWon't it be nice to
           get back where things work?@ and then run into this, it was
           ironic.
Harden:     Would you now walk me through the events in the Nigerian war
           that forced you to end the mission program and moved you into
           CDC?
Foege:           In the last part of 1966, and the early part of 1967,
           there was a lot of tension in Nigeria.  The east kept
           threatening to form its own country.  In retrospect, I suppose
           oil was behind this, but we didn't quite understand it at the
           time.  We continued working.  In late 1966, two very important
           things relating to smallpox happened during my time in eastern
           Nigeria.  One was a mass vaccination program we did in a place
           called Abakaliki.  We were very successful, getting about ninety-
           three percent of the population vaccinated.  We were pleased by
           this kind of coverage, only to see an outbreak of smallpox a few
           weeks later in Abakaliki.  We didn't think that this should have
           happened, because we believed in the idea of herd immunity.
           What was different about the outbreak was that it occurred in a
           religious group, Faith Tabernacle Church.  All of the cases were
           in the Faith Tabernacle Church.  The members of this church had
           refused vaccination.  The source of the outbreak had probably
           come from another Faith Tabernacle member outside of Abakaliki.
           The point is that we found that no level of vaccination in a
           population was so high that you could exclude the possibility of
           smallpox.  That's one thing that happened.
Harden:     You said that your independent project at Harvard was to come
           up with a smallpox vaccination strategy.  Had your strategy for
           that project been mass vaccination?
Foege:           Everyone in those days was thinking in terms of mass
           vaccination, and that's what I was thinking of when I was at
           Harvard, that if you got to a certain level of vaccination, you
           would make it so difficult for smallpox to be transmitted that
           it would just die away.  That's what we thought, but the
           experience in Abakaliki proved otherwise.
                 The second thing that happened occurred on December 4,
           1966.  It was a Sunday.  I got a radio message from Hector
           Ottomueller, a missionary, who asked if I could come to look at
           what he thought might be smallpox.  We went to the area, which
           was probably six, seven miles off of a road.  We used Solex
           bicycles, French bicycles with a small motor on the front.  They
           were so light that when you came to a creek, you could actually
           walk across on a log holding the bicycle in one hand.  They were
           a very efficient method of transport.  Sure enough, these were
           smallpox cases.  It was so early in the program, we didn't have
           much in the way of supplies, and then I learned we wouldn't get
           any more supplies.  We were faced with the question of how to
           use our small amount of smallpox vaccine most effectively under
           these conditions.
                 That night, we went to a missionary's house to take
           advantage of the fact that they got on the radio with each other
           at 7:00 pm each night to be sure no one was having a medical
           emergency.  With maps in front of me, I was able to give each
           missionary a geographic area, and ask if they could send runners
           to every village in that area to find out if there were any
           smallpox cases in any of the villages.  Twenty-four hours later,
           we got back on the radio to see what they had found.  That night
           we knew exactly where smallpox was.  Our strategy was to use
           most of the vaccine in the villages where we knew that smallpox
           existed.  Second, we tried to out-figure the smallpox virus.  I
           mean, we literally asked ourselves, "If we were a smallpox virus
           bent on immortality, what would we do?"  The answer was to find
           susceptible hosts in order to continue growing.  So we figured
           out where people were likely to go because of market patterns
           and family patterns.  We chose three areas that we thought were
           susceptible, and we used the rest of our vaccine to vaccinate
           those three areas.  That used up all of our vaccine.  We didn't
           know it, but in two of the areas, smallpox was already
           incubating, but by the time the first clinical cases appeared,
           those areas had been vaccinated.  And so smallpox went no place.
            By three or four weeks later, the outbreak had stopped.  And we
           had vaccinated such a small proportion of the population!
                 There was this contrast between the situation in
           Abakaliki, with a very high percentage of coverage and still a
           smallpox outbreak, and that in Ogoga province, with very poor
           coverage, but with an outbreak that was halted.  We began to
           wonder if this new strategy might be worth trying in larger
           areas.  We talked to the Ministry of Health.  It was a very
           crucial time, because war was being talked about every day.  The
           Ministry of Health said that in the eastern region, they were
           willing to change the whole strategy against smallpox.  We could
           put all of our attention on finding smallpox and containing each
           outbreak.  Five months later, when war fever was  at a peak, we
           were working on the last known outbreak in that entire region of
           twelve million people.  In five months, we'd cleared out every
           outbreak.  We were working on the last outbreak when war broke
           out.
                 Now I didn't know that war was going to break out at that
           moment.  The smallpox program had planned a meeting in Accra,
           Ghana, for the first of July, 1967.  I went to the American
           consulate in Enugu and asked, "What's the chance that there will
           be fighting in the next weeks?"  And they said, "Not a chance.
           Neither side is strong enough at this point to actually initiate
           anything."  But the border had already been closed between the
           east, which called itself Biafra, and the rest of Nigeria, and
           six weeks earlier, we had sent our wives and children out.  We
           had gone to Port Harcourt, where our wives and children got on
           planes.  They were DC-6s, I can still recall.  It took forever
           for them to get off the runway, because every seat had an adult
           and a child.
Harden:     And where did the planes go?
Foege:           From Port Harcourt to Lagos.  Port Harcourt was in the
           east, but they had received permission for people to fly out.
                 When the smallpox meeting was about to start in Accra,
           Ghana, I determined from the consulate that we would not have to
           worry about fighting in the short term.  We crossed the Niger
           River in canoes.  They were slightly big canoes.   There was no
           formal border between the two regions.  And yet, we got our
           passports stamped on each side, by people who were pretending
           that this was all legitimate.  We got taxis from the other side
           of the river to Lagos, and  from there we got to Accra.  We were
           in Accra at this meeting when the fighting broke  out.  The
           American consulate had it all wrong, and we couldn't get back.
           We did not know for months whether that last outbreak had
           actually been contained or not.  It turns out that it was
           contained.  There was never any smallpox in the area of fighting
           during the Nigerian-Biafran civil war.  That turned out to be a
           real blessing.  But think of how close we came.  There was a
           window of opportunity because of our December experience with
           the small outbreak.  We had asked if we could try this strategy
           on a larger area, and in five months we had cleared out smallpox
           from the entire region.  Because of that, smallpox turned out
           not to be a factor in the war.
Harden:     So you knew by then that this method of
           "surveillance/ontainment" or "eradication escalation"--whatever
           term we are going to use--was a more effective way to eradicate
           smallpox.  And at this point, when you were asked to come back
           into CDC, you must have had to sell this idea to people.  Tell
           me about whom you had to sell it to, and what you did to sell
           it.
Foege:           At the end of the meeting in Ghana, I wasn't quite sure
           what to do, since the east was now closed because of the war.  I
           went back to Lagos, and it was decided that I would work in
           northern Nigeria for a while.  I also need to step back just a
           few weeks, or a few months, to say that on one morning, in
           Enugu, a Saturday morning, we went in to work and found that
           there were cases of smallpox in the hospital in Enugu.  And
           suddenly we knew we had to do something in Enugu itself and
           spent the rest of that day planning for doing vaccination in
           Enugu.  That afternoon, I went out in a VW bug, and mapped out
           the places in Enugu where you had enough room that you could
           actually have people lined up to do vaccinations.  I was not
           thinking of anything except smallpox at that point.  But
           suddenly, I was surrounded by police.  Someone had reported that
           there I was with maps, and of course that looked suspicious, so
           I was arrested.  It took hours before they would allow me to
           make a phone call.  I wanted to call my wife, so that she would
           know why I wasn't coming home for dinner.  They would not let me
           do that.  But they eventually let me call my counterpart, Dr.
           Anazanwu, in the Ministry of Health, and he came down and got me
           bailed out.  I tell this just to make the point that I had been
           arrested by the Biafrans.
                 When I went to work in northern Nigeria, I was in Sokoto
           province, which is up in the northwest part of Nigeria.  I had
           just set up a tent for the night, and was getting ready to cook
           dinner, when a pickup drove up and police officers got out.  A
           man came up to me, gave me a piece of paper, and asked me,"Is
           this you?"  And there was my name on the paper.  And I said,
           "yes."  And he said, "You're under arrest."  He would not
           communicate anything more.  He would not say why I was under
           arrest, but I had to put everything together and get into the
           back of the pickup.  And we started the long trip back.  At one
           point, they stopped at a guest house in order to go in and drink
           beer.  They left me alone, sitting in the back seat of that
           pickup, with a pistol on the front seat.  I knew I didn't want
           to move at all, which I didn't.  They came back, and we
           continued to ride.  In Kaduna I was put under house arrest, and
           after several days, they said that they would allow me to leave
           the country, if I would never return.  I left and flew out to
           Ghana.  But a few weeks later, I was asked to go back to Lagos
           by the regional office of the smallpox eradication program.  I
           knew how poorly official records were kept, so I went back, and
           there was never any problem.  The point I am making is that I
           was arrested by both sides, which showed my neutrality.
                 When I went back to CDC, I expected that the war was going
           to be finished within weeks.  That was my thinking, and when I
           returned to CDC, I came back as a contract employee for what I
           thought would be a period of weeks or months.  I began working
           on the idea of using surveillance/containment throughout West
           and Central Africa.  That's what I worked on--selling the idea.
            Some people were sold immediately.  I mean, I think of Don
           Hopkins [Donald R. Hopkins] going to Sierra Leone, which had the
           highest rates of smallpox in the world.   Sierra Leone at that
           time had poor communications and transportation.  He started out
           from the beginning, doing surveillance/containment.  He never
           bothered with mass vaccination, and surveillance/containment
           worked, well.  Other people were more reluctant, and I can
           understand that.  We had sold most of the governments on
           universal vaccination.  Eastern Nigeria had been easy to
           convert.  They saw the logic, but it was not that easy every
           place.  But gradually, place after place did do this, and the
           bottom line was, we were able to eradicate smallpox in five
           years.  In country after country, smallpox disappeared.  I'm
           quite sure that in any geographic area where they converted to
           surveillance/containment, twelve months later, it was smallpox
           free.  Nigeria had its last cases in May of 1970, and the whole
           twenty-country West African area had smallpox disappear in three
           years and five months, a year and seven months before the
           target, and under budget.
Harden:     What I'm hearing from you is that each group working in the
           field had to choose to adopt this approach, that there was no
           top-down direction from Atlanta.  I thought that an order might
           have come from headquarters in Atlanta, instructing everybody to
           stop doing mass vaccination and start doing
           surveillance/containment.  That was not the way it happened?
Foege:           It's hard to make that kind of change when countries are
           autonomous and they have their own programs, and they've not
           been sold on a new approach.  Don Millar was an immediate
           convert to surveillance/containment, and he was in charge of the
           entire West Central African program.  Mike Lane had a fiefdom, a
           region that he was in charge of, and he was an immediate
           convert.  So, right from the beginning, we were talking this
           out.  With each meeting, it was possible to demonstrate that
           surveillance/containment was working in particular areas, and so
           gradually, everyone did come on board.  But it took a little
           while.  Nonetheless, to have smallpox disappear in three years
           and five months--it didn't take long.
Harden:     So the program agreements that were initially signed with each
           country had described mass vaccinations, and in shifting to
           surveillance/containment, you had to "sell" each individual
           country, correct?
Foege:           That's right.  And to me, the amazing thing is not that it
           took some period of time.  The amazing thing is how fast we
           changed strategy.  I mean, we just turned things upside-down,
           and it happened in twenty countries.
Harden:     To me, as a historian, the fascinating thing is how that
           flexibility was embraced.  So many times change is not embraced
           when somebody has a new idea and can demonstrate that it works,
           because people are so invested in the old idea.
Foege:           It also shows the value of having young people involved in
           the project.  Julie Richmond [Julius Richmond], the former
           Surgeon General, once said that the reason smallpox eradication
           worked is that the people involved were so young they didn't
           know it couldn't work.  And you know, that's probably true.
           People were very flexible.  And when you think of the number of
           people that went from CDC into West Africa, most of them had
           never had experience in West Africa.  And yet, they adapted
           fast.  I think, when you look at the group as a whole, what
           characterizes them is that they were problem solvers.  Everyone
           has mixed motives, of course.  It's hard to know exactly what
           motivates people.  Today I am often asked, "What is Bill Gates's
           motivation?  And I say, "How do I know?  I don't even know my
           own motivation, it's such a mixture of things."  The people
           involved in smallpox eradication had a lot of interest in doing
           new things, and exploring, and so forth.  But the thing that
           characterized them all was that they were problem solvers.  You
           couldn't give them a problem that was so difficult they didn't
           want to try to solve it.  And so, they were very adaptable.
           When a new idea came out, they quickly used it.
Harden:     In the middle of the West African smallpox eradication effort,
           there was a recommendation that smallpox vaccines be stopped in
           the United States.  Were you involved in these discussions?
Foege:           I was involved during those years.  In 1971, we really did
           attempt to stop smallpox vaccination in the United States.  It
           took a lot of courage to support that, because there was still
           smallpox in Africa, Pakistan, India, and Bangladesh--lots of
           places.  But but by then Mike Lane and John Neff and other
           people had done the calculations that showed what the risk was
           of the vaccine.  The United States had a risk of smallpox coming
           in from another country, but we concluded that the risk of
           importation was less than that of the vaccine itself.  Part of
           the reason is geography.  Europe acted as a filter for smallpox
           cases.  People coming from Africa or from India or Pakistan,
           often went to Europe first, and then to the United States, so
           Europe continued to have outbreaks, and we didn't.  We
           calculated the risk of smallpox coming to the United States.
           For instance, if you look at ships, because of the time it takes
           to get here, and so forth, we were able to calculate the risk of
           smallpox coming to the United States by ship was about one
           importation in 600 years.  It is far greater than that for
           airplanes, but it gives you an idea that it was possible to
           calculate the risk based on the incidence in a country, how many
           people go from that country to the United States, what
           percentage of them are probably not adequately protected, and so
           forth.  The recommendation to stop giving smallpox vaccinations
           in the United States came out in 1971.  It took quite a while
           before it was actually followed by everyone.
                 As a part of that recommendation, we also developed a plan
           for what to do if there was an importation.  Some of us went to
           the states-we got to all of the states--to train their public
           health officials as to what would be needed if a smallpox case
           was imported.  We used what was called the CASE manual.  "CASE"
           stood for Comprehensive Action for a Smallpox Emergency.  Inside
           the front cover of that notebook was a big chart that you unfold
           and put up on the wall.  It showed every step that you had to
           take.  And every step had a place in the notebook that gave the
           details.  Our point in designing this manual was that people did
           not have to study this ahead of time.  They just needed to know
           that it was available to tell them what steps to take if they
           thought they had a case of smallpox.  This was very important so
           that no one would panic if a case appeared.  The chart in the
           CASE manual was very clear.   I  think we did a good job of
           educating the state health officers, the counties and so forth,
           on what to do in case of a smallpox outbreak.
Harden:     Is there is anything else about the West African program you
           would like to talk about?
Foege:           I think we've covered the main things.  The only other
           things I had were stories of various kinds, but I don't think
           they're as important as the big picture.
Harden:     I'd like to hear those stories!
Foege:           The program itself, as you can imagine, was very
           difficult.  Communications were bad, transportation was
           difficult, it was often hard to get food.  It was not an easy
           time to be in an area in which civil war was about to break out.
            There were many tensions.  There were roadblocks where teenage
           boys with guns were drinking beer and making decisions.  This
           was difficult.
Harden:     Were you afraid?
Foege:           You always had to be a little bit afraid of a teenage boy
           with a gun who's drunk.  They do irrational things.  So, yes,
           you never wanted to talk back.  There are many stories from that
           time.  Once at these roadblocks, they looked into the trunk of
           one woman's car and saw that she had a labeling machine.  A
           labeling machine looks a little bit like a pistol, but not much
           like one, but they were curious to know what this device was.
           She explained that it would make their name, and then she showed
           them.  They spelled out their names, and she made a label for
           each of them.  When they cleared her to proceed, she continued
           down the road but heard a rattling in the trunk of the car.  She
           stopped to look and found three guns in the trunk.  Each boy had
           taken his label and walked off with it, leaving his gun.  She
           immediately drove back to return the guns, and of course, the
           boys were very nervous, thinking a commanding officer was going
           to come by and see that they didn't have their guns.
                 You worried about the roadblocks.  As the wives were
           leaving from Port Harcourt, one of our people had gotten a
           little upset with a guard who asked them once more to open their
           suitcases.  He said, "We've already opened it."  Of course,  the
           guard did not like his response.  Next thing, he had him in a
           room, with a guard and a gun.  Then this person realized that he
           had the key to his wife's suitcase.  The other guards continued
           to ask her to open it, but she couldn't because he had the key.
           He asked the guard, "Couldn't I just go out and give her the
           key?"  The guard said, "No."  So he said, "What would you do if
           I just stood up and walked over and gave her the key?"  The
           guard said, "I'd shoot you."  My friend stood up, and the guy
           cocked the gun. And my friend sat down again.  Then he asked me
           to come in, and I talked to the guard and asked if I could give
           the key to my friend's wife, and the guard let me do that.  But
           because of this confrontation, my friend was never even able to
           say goodbye to his wife.  So you just did not want to fool
           around with people.
                 One day, I was in a big, green International van, and we
           were driving down the road and saw a checkpoint up ahead.  The
           driver-there were just the two of us in the car--started putting
           on the brakes, but the brakes had gone out.  He tried to pull
           the emergency brake, but it did not work, either.  The last
           thing he was going to do was go through that barrier, and so he
           went off the road, into a ditch.  We bounced around, hit a tree,
           and ended up against a building.  Suddenly, we were surrounded
           by people.  This is a common thing in Africa.  You think you're
           out in deserted land, but as soon as something happens, you're
           surrounded by people.  It took a while for me to realize what
           was happening.  The local chief came, and he was a real orator.
           He began telling me what we had just done.  He said that that
           tree we hit was a juju tree, and that we had offended it by
           knocking it down with our vehicle, and so he would have to do a
           sacrifice.  He would sacrifice a chicken.  This chicken would
           cost ten shillings.  When he was all done, and it took him a
           long time to get to that point, I breathed a sigh of relief,
           because I hadn't  known what was coming.  Ten shillings--that
           was nothing.  But then something perverse took over in my mind,
           and I began talking back in the same way that he did, telling
           him that I understood all of this, and that, yes, we had our own
           kind of customs where I came from.  Where I came from, this
           vehicle was considered to be a juju god, and it had been very
           offended to have that tree there in its way, and that I would
           have to sacrifice a goat, which would cost twenty shillings.
           And then I pulled out ten shillings, and asked, "To whom do I
           give the ten shillings, and who will be giving me the twenty
           shillings?"  There was such a silence that I feared I had made a
           mistake.  It was just deathly quiet.  And then, one man started
           laughing.  And with that, a few others laughed, and pretty soon
           everyone was laughing, they saw the joke.  No money changed
           hands, and we got out of there.
Harden:     I would also like to ask you: When you have lived like this in
           Africa, how you readjust to living in suburban U.S., with all
           the fast food, with all the affluence?
Foege:           It's an interesting experience to live overseas, and many
           people find it a great experience, because they have servants
           and they get privileges that they wouldn't have in the States.
           We didn't quite have that experience, having started out in a
           village, where living was very difficult, and much of your day
           was consumed in just boiling water.  We didn't have electricity,
           so we couldn't even have a fan to help deal with the heat.
           Despite these difficulties, it was hard to come back.
           Everything seems too easy to you when you return.  But there was
           a good part of this change.  When we were using many CDC people
           in India on ninety-day TDY projects, I got a letter from Don
           Millar, who was providing a lot of the people.  He said, "I
           don't know if they're helping you at all with smallpox
           eradication, but keep asking for them, because they come back
           different people.  They have now experienced what it's like to
           have real problems.  They don't put up with a lot of the things
           in the United States that cause problems.  They just steamroll
           over them."  So there are good points and bad points about
           coming back to the U.S.  Living overseas is a broadening
           experience, and I think it's so important for people to have
           that experience.  They come back with some difficulty, but they
           come back with a different perspective of how fortunate they
           have been.
Harden:     When zero pox was achieved in West Africa, the outside funds
           for the CDC efforts pretty much dried up, but Dave Sencer [David
           J. Sencer] was unwilling to let the program die.  He appointed
           you to be head, and sent you out to insure that the worldwide
           effort was going to be successful.  Can you tell me about this
           transition, and what actions you took?
Foege:           There were two things that happened after smallpox
           disappeared in West Africa.  First, we must remember that this
           was always a smallpox and measles program.  Measles was a major
           cause of death in West Africa, and it's interesting that USAID,
           the funders for the program, always referred to this as the
           measles/smallpox program.  The CDC always referred to it as
           smallpox/measles, not because smallpox was more important than
           measles, but because it was part of a global effort, and
           eradication was uppermost in our minds.  We believed that if we
           were not able to achieve eradication in West Africa, the global
           effort would most likely not succeed.  At the end, we assumed
           that USAID would see the benefit of continuing the measles part
           of this, because measles deaths had been greatly reduced,
           hospital beds that had been taken up by measles cases had now
           been freed up for other patients.  We had no idea at that time
           that they were being freed up for AIDS cases in the future, but
           that's what happened.  I was very surprised and shocked when
           USAID made a decision to stop the measles part of the program.
           It was very shortsighted to get West Africa accustomed to having
           measles vaccine available to reduce this terrible plague, and
           then to say, "We're going to stop the program.  Now you're on
           your own."  We tried very hard to get the measles program either
           continued or at least tapered off over sufficient period of
           time.
Harden:     Who made this decision?
Foege:           It was a decision, as far as I can tell, of one person at
           USAID, who was new, who didn't have an emotional commitment to
           the measles vaccine program and who wanted to do his own things.
            That made it extremely difficult, and as hard as we argued, we
           could not persuade him.  I actually wrote a letter for Dave
           Sencer's signature to go to the head of USAID, which hopefully
           would put some pressure on them to continue the program.  It
           went to someone in USAID, who sent it to me for a response.  And
           that's when I realized how much fun government could be, that
           you could write your own letter and respond to it, also.
                 The second thing that we did was to look at the rest of
           the world with an eye to smallpox eradication.  We were very
           concerned about India.  India turned out to have more intense
           smallpox than what we encountered in Africa, although we didn't
           realize it at the time.  India had had smallpox eradication
           efforts for decades, going back to the early 1800s.  But
           somehow, they never quite worked in India.  After discussing
           this with Dave Sencer, we made a decision that I would go to
           India for reconnaissance, to see whether it was possible to do a
           smallpox eradication project there.  In August and September of
           1973, I went to India and spent time with their Ministry of
           Health people and with people in the regional office for WHO
           [World Health Organization].   The result was that India turned
           out to be the site of our next smallpox eradication venture.
                 India was, in many ways, so much more difficult than
           anything we had faced in Africa.  The peak of smallpox in India
           was in May of 1974, when we had the highest rates that India had
           seen for decades.  They were much higher than anything we had
           suspected we would have.  In the fall of 1973, D.A. Henderson
           [Donald A. Henderson] asked me, "What's the largest number of
           cases that you can expect in any week in any one state next year
           in India?"  We did some calculations and decided it would be
           about 300 to 400.  He said, "Just to be sure, we're going to
           program our computers with four digits, and not with three.   I
           recall in May of 1974, having to call him and say that in Bihar,
           India, in one week, we had over 11,000 new cases of smallpox.  I
           mean, it was just overwhelming.   But we went from that high in
           May of 1974, to zero for the entire country of India in twelve
           months.
Harden:     Using the same surveillance/containment method?
Foege:           Using the same surveillance/containment, which many people
           did not think would work in India, because of the population
           density, and the high incidence of smallpox.  And yet, smallpox
           was eradicated in twelve months' time, once we got geared up to
           have really good surveillance.  I'm talking about surveillance
           that was so good that every three months, we would visit every
           house in India, looking for smallpox in a six-day period of
           time.  In six days, 100 million homes would be visited to see if
           there was anyone with smallpox.  And this was before computers.
           The logistics of trying to get people to 100 million homes in
           six days, and then finding, on evaluation, that over ninety
           percent of those homes had actually been visited, demonstrated
           the effectiveness of the Indian bureaucracy once they commit to
           something.
Harden:     That's very interesting.  So you were working with the Indians,
           then, and they were going into the homes.  That requires huge
           manpower and management resources.
Foege:           It required, in those six days' time, to mobilize lots and
           lots of the health workers, to take them off of other things for
           six days.  It also meant hiring a lot of day laborers in order
           to get the work force to do this.  For me, the interesting thing
           was that we did not have the government of India and WHO and
           other groups officially involved.  We worked so closely
           together, and I think part of the reason we were able to do that
           is, that we started traveling by train together.  This meant
           being together overnight in a compartment, which gave us the
           opportunity to talk in a way that we never would have by going
           into someone's office for an hour's meeting.  I mean, we were
           really in this together.
Harden:     What impact did your years in Africa and India, and the
           smallpox program in general, have on your family?
Foege:           I think the family saw our time in Africa and India as
           interesting times.  I mean, our children often look back on
           India as something they really enjoyed doing.  For birthdays,
           the person with the birthday gets to choose where we go for
           dinner, and inevitably, they want to go to an Indian restaurant.
            That's the way they feel about India.  I took one of my sons
           back to India when he was 18, when I attended a professional
           meeting there.  It was in Udhampur, and we decided, rather than
           fly down from New Delhi, that we would "experience" India again.
            We hired a car and a driver and began the thirteen-hour trip.
           This was in July, when it is very hot in India.  I recall, two
           hours into the trip, saying to myself, "This was a mistake."  It
           was so hot.  And of course the windows had to be open, because
           we didn't have air conditioning.  Diesel fumes from the exhaust
           and dust came in, and I looked over at my son, who had sweat
           rolling off his face, and I asked, "Michael, how are you doing?"
            He looked at me, and he said, "You'll crack before I do."  I
           mean, they just enjoyed India.  And it's given every one of them
           a feeling about the world that I like to see.  They are
           concerned about the developing world, they're concerned about
           the inequities that one sees in this country, and between this
           country and other countries.  It's something that I attribute to
           their having lived in other areas.
Harden:     Did any of them follow you into a medical career, or public
           service, or public health?
Foege:           Two of them are teachers, and I consider this to be even
           more difficult than doing public health work, because you don't
           get compensated well for your work as a teacher.  What we pay
           teachers is a crime.  The third one went into anthropology.  All
           of them have this feeling of concern about needing to help and
           understand other people.
Harden:     Before we stop, is there anything else that you would like to
           add?
Foege:           I see war around the world.  We have over a hundred
           conflicts going on at any one time.  But if you're not actually
           in the area, it's just a news story.  I think of what it was
           like during the Nigerian Civil War, the kind of devastation, and
           people starving.   People actually starved during that war.  I
           went back to work in the relief action.  I went into one town
           where you actually had to step over dead children as you walked
           down the street.  This is not the way the world should be, and
           yet we don't seem to learn.  How do you actually get people to
           make eye contact, to engage with this sort of thing?  For
           example, what's happening in Iraq right now shouldn't be
           happening at all.  How do you get people to understand that this
           is absolutely the wrong way for us to be living?
Harden:     Thank you for a very fine interview.
&lt;/pre&gt;</text>
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. Stanley Foster about his activities in the
West Africa Smallpox Eradication Project. The interview is being conducted
at the Centers for Disease Control and Prevention as a part of the 40th
anniversary observance of the launching of the West Africa program. The
date is July 14, 2006, and the interviewer is Victoria Harden.

Harden:     Dr. Foster, would you begin by just briefly describing your
           childhood and your growing up, and who made you who you are.
Foster:          Okay. I grew up in Melrose, Massachusetts. My family was
           very religious. My father died when I was 9 years old, and one
           of the things that happened soon after that was I met Gordon
           Seagrave. He was the famous missionary surgeon whose Burmese
           nurses provided the medical care to Stillwell's troops during
           World War II. And he became my role model. From that stage on, I
           was going to be a doctor. I went to Williams College and then
           went on the University of Rochester.
                 I think the connection to CDC was through D.A. [Donald A.
           Henderson], who also graduated from Rochester, as did Deane
           Hutchins. At that time, in early '62, they were drafting
           doctors, so I decided I'd rather come to CDC than go to the
           Army, so I came here. One of the interesting things that sort of
           started it off was that with 2 "F" names, Bill Foege [William H.
           Foege] and I sat next to each other in the EIS class of '62. I
           was assigned to the Indian Health Service in Arizona and carried
           out 18 epidemiologic studies. My basic assignment was for
           trachoma. At that time, about 20% of the Indian children had
           trachoma.
Harden:     Had you specialized in infectious diseases or anything in your
           medical training?
Foster:     Internal medicine was my field. And, as was often the case,
           Alex [Alexander Langmuir] would try to seduce officers he wanted
           to stay. He sent me to Bolivia to investigate an outbreak of
           conjunctivitis in Peace Corps volunteers. I came back to my home
           in Phoenix, got to Atlanta at about 3:00 in the morning, and at
           6:00 in the morning I was on a plane back to Phoenix and on the
           way to the Truk Islands in the South Pacific to investigate an
           outbreak of diarrhea with Palmer Beasley.
                 The assignment was an epidemiologist's paradise because a
           boat would only go out to an island once a month. You would know
           the entry point, and there would be a health worker there who
           would write down the cases and the names. It was a great
           epidemic. And the pattern of transmission was that of influenza,
           but the disease was diarrhea. We brought back the specimens, and
           the lab tested them out. They couldn't come up with an agent. We
           tried to write up the article several times, but without an
           agent, we couldn't. Twelve years later, when I came back from
           Bangladesh in '76, the lab called me and said, "We just found
           out what your '64 outbreak was. It was a rotavirus."
Harden:     Rotavirus. Ah.
Foster:          So we pulled out the article, finished it, and got it
           published.
Harden:     So you were doing epidemiology up until 1966?
Foster:          Well, no, that's not quite true. I did my EIS training
           from '62 to '64. Then I left CDC and went back to Rochester for
           a year of residency. Then I went to the University of California
           in San Francisco and did a fellowship in pulmonary disease. I
           probably would have stayed on in San Francisco in pulmonary
           disease, but I got the call from D.A., saying, "Do you want to
           go to Africa and get rid of smallpox?" My wife and I thought
           about it, and we decided after 24 hours that was right. We had 3
           kids at the time, and I think one of the things we need to
           discuss is wives and kids.
Harden:     Yes.
Foster:          In terms of the impact of those experiences on the kids.
           Three or 4 of my kids' careers developed out of experiences with
           smallpox. My oldest son was interested in traditional medicines,
           and he now does Internet work in China. My second son, when he
           was in the 8th grade in Dhaka, Bangladesh, did a study of
           rickshaw drivers and how much of their income they spent on
           food. Now he's the chair of the Department of Economics at
           Brown. My third son got his start, really, in 1974 in
           Bangladesh, when we had tremendous floods and a famine. People
           were dying on the streets in front of our house. And he decided
           to go into medicine. I had no knowledge of the impact that the
           famine had on him until I read his Peace Corps application. And
           then I understood that that experience, back in '74, was the
           major event that sent him into medicine.
Harden:     This is very interesting. You said you came from a religious
           family. Were they missionaries or ministers?
Foster:          No, my wife's folks are missionaries. They went to
           Guatemala on their honeymoon. And her mother was interesting.
           She refused to go as a missionary wife. She said she'd only go
           as a missionary, and that was back in the '20s. They went down
           to Guatemala and learned Spanish. Then they learned Mayan and
           put the Mayan writing into a written language. And then they
           translated the New Testament. They had a school and a clinic.
           They stayed there for 45 years. Every year or 2, my wife and I
           go back to that same town. My wife is fluent in the Mam
           language. We have a nurse we work with, and she tells us what
           she wants us to teach.
Harden:     I'm interested in this streak of idealism.
Foster:          Oh, you should get a copy of my college caricature. I have
           a digitalized copy. It shows me sitting in a pot in Africa, with
           the pygmies standing around. "Bless this food to our use" and
           "Dr. Stanley, I presume" written at the bottom. I did have a
           missionary bent at that point in time.
Harden:     I'm seeing a different type of person who has been involved
           here at CDC with the smallpox program than what I have seen with
           investigators at NIH [the National Institutes of Health] in
           terms of the things that motivated them to go into research.
           Let's talk about once you were recruited into the program. They
           asked you apparently to recruit others, as well. And you
           mentioned that the recruitment of this 1 person.
Foster:          Andy Agle [Andrew N. Agle].
Harden:     . . .was interesting?
Foster:          Yes, it was very interesting. Andy was a public health
           advisor and a good mechanic. I remember, I met him at a building
           in San Francisco. He walked in, and he said, "I saw this
           advertisement that you wanted a public health person who spoke
           French and was a good mechanic, and I knew you needed me." That
           was it.
Harden:     Very confident.
Foster:          Yes, he was, there was no question about it. Andy turned
           out to be one of the best. He worked for a long time in West
           Africa; then he was working with smallpox in Afghanistan. He was
           getting bored with Afghanistan, and I brought him to Bangladesh.
           Then he worked for many years at the Carter Center and was very
           close to [President] Jimmy Carter. He did a lot of agricultural
           stuff and really worked incredibly well with the Carter Center.
           And then he took a job in Nigeria. He died about a year ago.
Harden:     Initially, you were the medical officer in Nigeria. Would you
           tell me which region you were in, and what you found?
Foster:          Well, I was responsible for the whole country. At that
           time, Nigeria had 4 regions. the West, the Midwest, the East,
           and the North. About half of the population was in the North and
           about half in the South. We had Margaret Grigsby and Jim Lewis
           in the western region; Warren Jones was in the Midwest; Bill
           Foege, Dave Thompson [David M. Thompson], and Paul Lichfield
           were in the East; and Deane Hutchins and Vicky Jones [Clara
           Jones] were in the North. And it was a very different program in
           the North than in the South.
Harden:     Would you tell me about that?
Foster:          In the North, the traditional leadership was incredibly
           strong. I remember the first village I went to, Gwadabaw, in
           '66.I got there at 6:00 in the morning, and there were 6,000 men
           in a line. We vaccinated the men, and then they went home, and
           then the women came out. Well, for the women to come out was a
           big social occasion. They really didn't want to go back in.
                 But I learned something that day, which was very
           interesting. It was a big district, and I told the district head
           that we should have 3 vaccination sites in his town because it
           would take us too long to do it at 1 site. He said, "I forbid
           you for doing that." He says, "Everybody has to be vaccinated in
           front of me. Nobody will tell me that they were vaccinated if it
           had to be in front of me, whereas if there were 3 sites, they
           could be tell me they were vaccinated when they weren't. The
           Emirs of Sokoto, Katsina, Kaduna, and Kano were very powerful
           people. The Emir of Sokoto would ride around in his Mercedes
           every night, and if there was no petrol, the Mercedes got pushed
           around town. But he was very powerful. So the only thing that
           you had to do in the North was to convince the Emir, and he
           would call in his district heads, and then everything would
           happen. It was easy to get 96%-98% coverage in that region. In
           the South, it was much more difficult. The people would not go
           200 or 300 yards for vaccination. People were much more
           independent in the South. There was not the structure, and it
           made it much more difficult to get people to come for
           vaccination.
Harden:     Why would they not want vaccinations?
Foster:          Well, I think if you go historically back, there was a
           demand for injections. We believe that occurred secondary to the
           yaws program, which gave shots of penicillin to treat yaws. But
           it cured venereal diseases and pneumonia and everything else. So
           injections were always sought after. In the North, the structure
           was such that people would be told to do it and they'd do it. In
           the South, you had to really convince them or use enough
           publicity to get people to come for vaccination. So it was a
           totally different thing.
                 And the epidemiology of measles was different. In the
           North, where the women are in purdah, or where the population
           density was relatively low, the median age of measles was about
           36 months. In Lagos, where you have mothers carrying their
           babies on their backs to market, the median age was around 14
           months, and then that was with a population of 600,000. When I
           went back in the '80s and '90s to Lagos, which now has a
           population of over 10 million and possibly 20 million, the
           median age of measles had dropped even further, to around 8
           months. Controlling measles was impossible.
Harden:     What was the toughest problem you encountered?
Foster:          Oh, the Biafran civil war. I had flown to Benin to see
           Warren Jones there. I got off the plane, and Biafran hijackers
           got on and hijacked the plane. And that plane later was used to
           bomb Lagos. It was very interesting: we believe that they were
           using the passenger plane as a bomber, defusing the bombs, and
           throwing them out the door. We felt that probably the reason
           that the plane exploded was because the bomb went off before it
           got out the door. Of course, they had to find somebody who was
           asleep at their gun to reward for shooting this plane down. That
           was tense, and a lot of people were evacuated.
                 I was talking with Deane Hutchins at lunch. I took the
           kids and my wife up to Kaduna because I thought it was safe. The
           next day, they bombed the Kaduna airport. But one of the
           interesting things at that time, we knew there was no smallpox
           in Biafra; but I was really afraid smallpox would get into
           Biafra. So I convinced the government that the safest thing for
           them to do was to vaccinate a large area around Biafra so that
           the smallpox wouldn't get out of Biafra into Nigeria. That way
           we kept it out. We also vaccinated a lot of children coming
           through the lines. The malnutrition in pockets of Biafra was
           just absolutely terrible. I think the war was really the
           toughest obstacle. The regional office was shattered by the
           bombings in Lagos, and it was not as safe a place as it had been
           before that.
Harden:     How did you get along with your counterparts?
Foster:          Oh, I had the most wonderful counterpart in the world, a
           fellow by the name of Yeme Ademola, who had gone to the Harvard
           School of Public Health. If you go back into the history of the
           smallpox/measles program, USAID [US Agency for International
           Development] wanted to do all the countries except Ghana and
           Nigeria. And Ademola was one of the ones who achieved its
           inclusion in the program He actually went and met with Senator
           Kennedy [John F. Kennedy] to push that.
                 Yeme was just so honest. He looked out for the poor. For
           example, he had a cooperative grain bank, where he would buy
           produce when the price was low, and then they would sell it when
           the price was high. He supported a clinic. He was just an
           absolutely wonderful guy, and he also was my neighbor. So he and
           my wife would often go out and have tea with Yemi and his
           British wife. He also is the subject of the most traumatic part
           of my time in Nigeria. I got a call one night about 3:00 in the
           morning, Rosa, his wife said that he had been attacked. When I
           arrived at the front door, the murderers went out the back door.
           He had been macheted across the neck. I went in and tried to
           save him, but I couldn't. And at that time, I wasn't thinking of
           my wife, who was pregnant. Panicked about me, she started to
           abort. It was a horrible day. And then the next day, the police
           came and wanted to put me under arrest for Yemi's murder. After
           a 6-hour standoff, the American Embassy got me off on account of
           my diplomatic status. So that was the single most traumatic
           event of my years in Nigeria.
                 We had an incredibly interesting team. We had Deane
           Hutchins and Vicki Jones. My favorite story of Vicki was when
           she went out in the field once for 4 or 5 weeks, and she'd
           either broken or forgotten her mirror. When she came back to
           Kaduna and looked at the mirror, she said, "Something's wrong."
           And then she realized it was that her face was white. In other
           words, she'd only seen black faces for 6 weeks. But she was
           wonderful.
                 The teams in the North were also just absolutely
           extraordinary people. They had a driver there. He would know,
           when he went into a village, who you needed to see first, who
           you see second, and who you should see third. He had driven for
           a political figure before that, and he was just good. The teams
           would go, and they could vaccinate with the jet injectors, 8,000-
           10,000 a day. The most I ever remember vaccinating in a day was
           once in the Midwest: with 4 lines we vaccinated 14,000.
Harden:     Wow.
Foster:          I think it's important to put in perspective what Henry
           Gelfand had learned about India. The Indians had vaccination
           numbers greater than the population, but they still had lots of
           smallpox. So Henry Gelfand went out there and did an assessment.
           And he found the vaccinators were vaccinating the schoolchildren
           regularly, so that they could get high numbers of vaccination,
           but coverage was very low. So when we went to West Africa, we
           were absolutely sure that with high coverage (Rafe [Ralph H.
           Henderson] and Don Eddins adapted coverage surveys from the US
           immunization survey to Africa) we would stop smallpox. There was
           no question about it. And that was our strategy, and we were
           absolutely sure that with high coverage with the jet injectors
           and coverage surveys-if we got above 90% coverage, or 95% or
           even better-we'd stop smallpox.
                 Four or 5 major events led to a change in that strategy.
           The first was that when we first arrived in Nigeria, there was a
           smallpox outbreak in eastern Nigeria, in Ogoja, where Bill Foege
           had been a missionary. They had a limited amount of vaccine. But
           by focusing the vaccine on the infected area, they stopped the
           outbreak. The second important thing was a series of spot maps
           that Bill Foege drew. Each year the smallpox would come from the
           North, and there'd be a few outbreaks on the northern border and
           in the East. Then the outbreaks would increase in number and
           frequency, so you could just see it spread southward. And
           although Bill doesn't remember this, I remember Bill sitting on
           the steps, looking at these monthly maps and seeing how the
           smallpox spread. And he raised the question, "If we stop these
           first few outbreaks, will we stop them all?" The third major
           event in the shift in strategy occurred in Abakaliki. (There's a
           nice paper about this by Dave Thompson and Bill.) They'd done a
           coverage survey, and Abakaliki had over 90% coverage. Then all
           of a sudden they had an outbreak of smallpox. The outbreak
           occurred in a religious group that had refused vaccination; I
           think it was called Faith Tabernacle. Smallpox even though the
           coverage in that area was 90%; the small group of unvaccinated
           people was able to sustain an outbreak. The fourth factor was
           the shape of the epidemic curve-a low in September-October and
           epidemic in the early spring. Bill figured it out that every
           chain of transmission in the fall caused 74 cases in the spring.
           He realized that the peak time for surveillance was when the
           chains of transmission were fewest. So, in my opinion, those
           were the major events that shifted the strategy from mass
           vaccination and surveys to surveillance/containment. And that
           was certainly a major shift.
                 And I think, although the disease eradication programs
           were different, when you compare smallpox to malaria, malaria
           was a centrally directed program, and they never really
           responded to the signs of drug resistance, and insect
           resistance, and the program failed. Smallpox was different. The
           program was driven by data collected in the field. We learned
           from our failures and changed strategies to address them.
                 When I teach on lessons learned from smallpox/measles, one
           of the major things is learning from our mistakes, being willing
           to learn from our mistakes. My favorite story on this is about
           Sabour. He was one of my team leaders in Bangladesh. At this
           time, India was free of smallpox, but we were still having
           trouble. And I went up to see Sabour in Mymensingh, near the
           Indian border. If we did everything right, once we found an
           affected village, there should be no cases after 14 days-after 1
           incubation period. So I asked Sabour, "How many outbreaks do you
           have?" And he said, "Sixteen." And I asked him, "How many had
           gone more than 14 days." And he said, "Eleven." Well, this was a
           disaster. The people could've walked those cases across to
           India, where the reward was big, and made a lot of money. And so
           I said to Sabour, "What are you doing?" His response was, "I'm
           doing everything the book says. I'm putting the patient in the
           house; I'm putting a guard at the front door and the back door.
           I have an extra guard at night to keep the guards awake. I am
           making a list of visitors, vaccinating them, and putting them
           under surveillance. I'm vaccinating everybody in the household.
           I'm vaccinating everybody in a half-mile. And I'm searching
           every place in 5 miles." And then, across a cup of tea, an
           incredible smile. And Sabour said, "And today I found out why.
           I'm going in, and I'm asking for a list of visitors. They are
           not giving me the names of relatives who came to visit because
           they don't consider relatives as visitors. And so we added a
           list of relatives to the procedure and solved the problem."
                 I think that this story illustrates one of the main points
           to get at, that a lot of us at CDC who are in leadership
           positions got a lot of credit for smallpox eradication, but it's
           these people who worked 28 days a month in the field, month in
           and month out for 5 years, some of them, who were the real
           heroes of smallpox.
                 The other lesson to get out of this story was the
           importance of giving workers at the field level the indicators
           to assess their own performance. When they didn't meet them,
           they asked why and come up with a solution.
                 There's 1 other similar story from India, which is really
           important. At a critical time in the program in India, things
           were going to hell in a basket in Bihar, and the numbers were
           going up. And the Minister said, "I'm sorry, no more
           surveillance/containment. We're going back to mass vaccination."
           Bill spent the whole weekend with the Minister, trying to
           convince him to continue surveillance/containment. But the
           Minister said he couldn't take the political pressure and he had
           decided that the only solution was to mass-vaccinate. At the
           Monday meeting, the Health Minister of Bihar got up and said,
           "I'm sorry, WHO [the World Health Organization] has recommended
           we continue to do this, but I can't stand the political heat any
           more, so we're going back to mass vaccination." In the back of
           the room, a hand raised. And a man got up and said, "Mister
           Minister, I am a poor country doctor. But when we have a house
           on fire in our village, we direct the water at that house and
           not the whole village." And the Minister said, "You have 1 more
           month." And fortunately over that month things got better, and
           so they continued surveillance/containment. Both of these
           examples illustrate the really major contributions that poorly
           paid and unrecognized field workers made. They really deserve a
           great deal of credit for what went on and the success achieved.
Harden:     But don't you think it was also remarkable that the bureaucracy
           and the people at headquarters were flexible enough to ask for
           and act on that kind of information? Many times you get
           bureaucracies that think they know best, no matter what's coming
           in. I think the synergy was quite remarkable.
      Foster:    Yes. Well, I think that's the main difference between
            smallpox and malaria. When we introduced the reward for
            reporting smallpox in Bangladesh, I introduced a single reward.
            But after about 6 months, only 35% of the public knew about the
            reward. And then all of a sudden, I discovered my mistake. None
            of the health workers were telling the public because they
            didn't want the public to claim the money. So we doubled the
            reward to pay both the health worker and the public, and within
            4 or 5 months, 80% of the country knew about the reward.
Harden:     So getting the word out, and knowing how the culture operates,
           also played a huge role.
Foster:          The Bangladeshi field staff used to say that working for
           the smallpox program was the best form of family planning (they
           were never home) because at least their wives didn't get
           pregnant. As you look at the evolution of
           surveillance/containment in West Africa to the rest of the
           world, it's a steady thing. .Probably the best place it was
           demonstrated was in Sierra Leone. Don Hopkins didn't have enough
           material to do the whole country. So on 1 side he did mass
           vaccination, the other he did surveillance/containment. Smallpox
           stopped in the southeastern area but continued on in the mass
           vaccination area. That proved surveillance/containment worked.
           Secondly, the legacy of surveillance/containment out of West
           Africa clearly was key to the success of global eradication of
           smallpox. Had it not been developed, it is unlikely that we
           would have ever stopped smallpox, in Asia especially.
Harden:     What about the role of the bifurcated needle? In my mind, West
           Africa was the jet injector and Asia was the bifurcated needle.
Foster:          This is not quite true. When we shifted from mass
           vaccination to surveillance/containment, the bifurcated needle
           became the preferred route of immunization. The bifurcated
           needle was developed to vaccinate chickens. It had 2 main
           advantages. It increased the amount of vaccine available 100-
           fold. It only took 1/100 the vaccine required by the multiple
           pressure method, where a drop was put on the skin and the site
           was scarified by pressing a needle parallel to the skin 15
           times. The bifurcated needle take rates were 99% effective
           versus the traditional method's effectivity of 90%-98%.
                 In Bangladesh, the bifurcated needle totally transformed
           containment. We could train a villager to use the bifurcated
           needle in 10-15 minutes. This brought ownership of containment
           to the village and quicker, more effective, control. It also
           solved the problem of getting health workers to spend nights in
           the infected villages, a major problem in the early stages in
           containment in Asia. Once you were hiring vaccinators to
           vaccinate their village, the barrier of the stranger was
           removed, and accommodations in the infected village were
           possible and acceptable.
                 I think we go should back just a little bit, to 1945.
           After World War II, smallpox was endemic in most countries of
           the world, especially in tropical areas, where the liquid
           vaccine was unstable in the heat. So the development of the
           freeze-dried vaccine (you could carry it in your pocket, it
           didn't require refrigeration, and you could mix it up for the
           day and it would be good) was a big thing.
New topic relevant to West African program but not to smallpox
                 And then the initial development of measles vaccine, the
           Edmonston B measles vaccine, it could only be given with gamma
           globulin. And the vaccine was not, at that time, licensed. It
           had been tested in about 20,000 kids. At just about that time, 4
           Ministers of Health visited the States and NIH. Harry Meyer
           happened to talk to them, and one of them got very excited. The
           Minister of Health of Upper Volta said measles was killing 20%
           of the children in Africa and Meyer should come to Upper Volta
           (now Burkino Faso) to test the vaccine there. So the first year,
           Harry went to Upper Volta and tested the vaccine. The vaccine
           proved its safety and efficacy without gamma globulin: that was
           a major step forward. The demand was such that the next year
           they vaccinated 700,000 in Burkina Faso. It was a tremendous
           success medically and politically.
                 Then the United States expanded to the other countries in
           OCCGE [Organization de Coordination et de Cooperation pour la
           Lutte Contre Grandes Endemies] and that was when CDC first
           became involved. Probably the best story about that concerns
           Larry Altman [Lawrence K. Altman]. Larry's now a science writer
           for the New York Times. He was sent out to Mali to address
           problems with the measles program there. One day he sent back a
           cable to Washington that said, "The trucks don't keep the
           vaccine cold." And a cable came back from Washington, "Park in
           the shade." And so Larry sent a cable back, "Send trees."
                 The measles program was a smashing success medically and
           politically. You had 3 parallel channels. You had the smallpox
           channel going on at CDC; you had Harry Meyer, who had proved the
           safety and effectiveness of given multiple vaccines at the same
           time. And then USAID and measles. USAID for some reason thought
           they could vaccinate a fourth of the children the first year, a
           fourth the second, a fourth the third, a fourth the last, and
           they would be done. That was totally wrong. I was talking to
           Dave Sencer about a phone call he got from A.C. Curtis from
           USAID, who called him and said, "What about a measles
           eradication program," and Dave said, "No, it can't be done.
           Measles is only control, Smallpox is eradication. Why don't we
           marry smallpox and measles?" Without measles, there would have
           been no West African Smallpox Eradication measles Control
           Program, no global program, and probably no eradication of
           smallpox. The WHO 1,000-page history of smallpox has several
           flaws, the major one being the order of chapters. They placed
           the West African chapter after India and Bangladesh. Bangladesh
           and India built on the lessons learned in West Africa and
           succeeded because of it
                 While the marriage of smallpox and measles was key to
           smallpox eradication, the effects on measles were short-lived
           because of the lack of infrastructure to maintain vaccination.
           Successful control of measles has only been achieved in the last
           5 years with a new strategy. It should be recognized that Jean
           Roy, the Operations Officer in Benin, has been a key player in
           this success in bringing the League of Red Cross Societies into
           play-resources from the wealthier countries and Red Cross
           volunteers on the ground to mobilize the public.
                 It should also be said that the marriage of smallpox and
           measles was a major barrier between USAID and CDC. USAID felt
           they had been been conned. This was really the basis of a lot of
           the angst between USAID and CDC because essentially USAID paid
           the whole bill.
                 And I was talking to D.A. last night on the phone, trying
           to clarify a few pieces of history, which is always difficult
           with D.A. When the United States first agreed to do smallpox,
           there was a briefing of the US delegation to the WHO Assembly.
           Even the secretary of HHS [Department of Health and Human
           Services; then, it was Health Education and Welfare] was not
           aware of the plan. So then the announcement went out at the
           assembly, from President Lyndon Johnson, that the United States
           would support a smallpox eradication program in West Africa.
           Later, the smallpox/measles marriage took place. Clearly, Dave
           Sencer was a key actor in this. D.A. told me last night-which I
           didn't know-that that press release about smallpox was written
           by Bill Moyers. That was the international Year of Cooperation,
           or something like that. And smallpox eradication and the US
           contribution fit this like a glove from 3 perspectives: science,
           development, and politics.
Harden:     You have mentioned the 2 women who were professionals the West
           African Program. Neither of them is here for the reunion, but
           could you talk about who they were and how exceptional they
           were?
Foster:          Yes. Two very different people. Vicki Jones, young, free
           spirit, guitar-playing, and Margaret Grigsby, an older, African-
           American woman professor at Howard, very prim and proper. I
           remember we had some issues insuring that there was a proper
           latrine arrangement for her when she went to the field. And it
           was difficult in the area that Margaret was in, in terms of
           getting cooperation. Margaret was great. She had her heart and
           soul in the program and bonded well with her African colleagues.
           I do remember the first outbreak I went to in the western
           region. They had isolated the smallpox patients in a cocoa farm,
           and the only people who were allowed to go there were those who
           had the scars of smallpox. This is very, very interesting. On
           the other hand, you have the smallpox cult, Shapona cult, where
           if you didn't want to get smallpox, you paid the priest. If you
           got smallpox and didn't want to die, you paid the priest. And if
           you died, the priest got all of your worldly possessions. So
           they couldn't lose.
                 There are historical accounts, in the 1800s, of priests
           actually infecting people who didn't pay up by putting smallpox
           scabs on sticks going into houses. Actually, I remember the last
           African outbreak I visited, in Togo. A couple of the traditional
           healers were there trying to pick scabs. Fortunately, the scars
           were from a vaccinial modified case, so it was not likely that
           there was much virus left.
Harden:     What did Africa teach you about yourself and about public
health?
Foster:          We were young; we were bright; but we were not bright
           enough to say we couldn't do it. I mean, that was really
           important. In other words, there was never a sense that we
           couldn't succeed. It was a totally different story in
           Bangladesh. But we learned as we went along. We had pretty good
           government response and fairly credible civil service. At least,
           we were paying per diems and that sort of thing, kept people
           working. It was a well-oiled machine. I mean, we had something
           like 80 Dodge trucks in Nigeria. We had lots of spare parts. I
           think the last one I saw running was in the late '80s.
Harden:     What kind of impact do you think the whole West African program
           had on the global eradication program?
Foster:          Had West Africa not succeeded, it's doubtful that the
           global program would have succeeded. I have no question in my
           mind that it laid the foundation, and one of the great
           injustices in the smallpox book is that the West Africa chapter
           is put after India and Bangladesh. This is extremely unfortunate
           and historically incorrect because a lot of the lessons learned
           out of West Africa laid the foundation for what went on in Asia,
           and Ethiopia, and Somalia.
Harden:     Indeed. Is there anything you would change if you were running
           the program all over again?
Foster:          What we did then, we couldn't do now.
Harden:     Say again?
Foster:          What we did then, we couldn't do now.
Harden:     Why?
Foster:          I mean, it was pretty much an expatriate-run operation-
           money-driven, technology-driven. We did not have the proper
           amount of deference to local culture and societies and
           governments.
Harden:     I wondered about that.
Foster:          It was pretty much a technology-driven program. It was
           marvelous in terms of the teams we had. Some of the Operations
           Officers, Dave Bassett for one, George Stroh for another. George
           was driving from Jos down to the South when his motor mounts
           broke, and his motor fell out of his engine. He put the motor
           back in and drove home. I mean, just that kind of ability, to
           react in the field. So that was important.
                 In Asia, several things were key. One was that the monthly
           meetings were incredibly important. People came in, they gave
           their reports, they shared the successes, they shared their
           failures, they got drunk, they sobered up, they got their money,
           they went back to the field. And most of them spent 25-28 days
           in the field. And as I look at CDC people going in the field
           now, they don't do that much any more.
Harden:     Are there any final things that you want to say?
Foster:          The challenges of West Africa were nothing compared to
           what it was in Bangladesh, especially in the floods of 1974,
           when the 2 remaining areas of infection were totally flooded out
           and people went into motion. We went from 89 infected villages
           in October of '74, to 1,500 the following May. We were all
           depressed. We lost it. A wonderful guy, Rangaraj, was my deputy;
           he was the first Indian physician parachutist. He had fought
           with Stillwell in Burma. And every morning, he would say, "It's
           going to be all right. Hang in there." Every day, he was like
           that. There was no rationale for that. Later on, when I was
           working in Somalia, I had a beer with Rangaraj 1 night, and I
           said, "Ranga, how could you have been so optimistic?" He said,
           "I didn't think you had a chance in hell in winning, but when I
           fought with Stillwell in World War II, I learned that if you
           ever thought you'd be dead the next day, you would be dead." So
           it was his military training and his optimism that enabled us to
           keep going, during incredibly difficult times. When I walk into
           an HIV/AIDS village today, I feel Ranga's hands on my shoulder.
           "Hang in there it will be all right."
Harden:     And eventually, to win.
Foster:          Yeah, and eventually to win. And Ranga was incredibly
           important. And there were lots of people like that. In
           Bangladesh, we had 22 nationalities on our staff, and they were
           they best. I mean, they were family. We were all 1 family. The
           monthly meetings were key. Then surveillance got incredibly
           better, and we were able to track things. And we used money. We
           paid $25,000 in rewards starting at $2.50 per report of an
           infected village and increasing to $50 as the number of infected
           villages in Bangladesh decreased. And we learned. For example,
           when we started in Bangladesh, we were having trouble with
           containment until we started hiring people from the village. The
           reason we were failing was because health workers had no place
           to stay in the villages. Once you started hiring villagers to do
           the work, you had a place for your health workers to stay. And
           so there was a tremendous lesson.
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Jay Friedman on July 13, 2006, at the Centers for
Disease Control and Prevention in Atlanta, Georgia, about his involvement
with the West African Smallpox Eradication Project. The interview is being
conducted as part of a reunion marking the 40th anniversary of the launch
of the program. The interviewer is Diane Drew.

Drew: Would you mind giving me a little bit about your background, where
           you grew up, what's your education, that kind of thing?
Friedman:   I was born and raised in New York City, in the borough of
           Queens. I went away to college at the age of 17, to Florida
           State University in Tallahassee, Florida, where I graduated in
           1961.
Drew: And what was your field of study?
Friedman:   I majored in business administration-not that I was so business
           oriented, but I wasn't a great student and thought that was an
           easier path to grey hair. I was the equipment manager of the
           baseball team, which was a championship team. And, as equipment
           manager, I had a full scholarship, which my father loved, which
           is why I stayed at Tallahassee.
                 Following that, I went to law school for a year. But I
           didn't like it very much, and joined the Peace Corps in 1962. I
           spent 2 years in Sierra Leone, West Africa, mostly teaching
           English, math, and motor mechanics-
Drew: That's quite a combination.
Friedman:   -in a vocational high school in the city of Freetown. Motor
           mechanics because I had put my way through college working as a
           mechanic at an Oldsmobile dealership in Long Island, New York.
Drew: How cool.
Friedman:   Learned how to work on cars, which perplexed my father totally.
Drew: That's a very handy skill to have.
Friedman:   Yes. One problem is my knowledge of cars ended when I graduated
           from college in 1961, so I know nothing about newer cars, just
           old ones.
                 Following the Peace Corps, in 1964, I went to American
           University in Washington, D.C., majoring in international
           relations and economics, and, if you like, a minor in French,
           which I learned to speak fluently. I spent 5 months in France to
           that end.
Drew: What part of France?
Friedman:   I was in Paris, then in a small town called Boulogne-sur-Mer,
           which is right on the English Channel. From the high part of the
           town, you could see the White Cliffs of Dover.
Drew: Oh, wow!
Friedman:   We used to go on weekends in France.
Drew: So you were really immersed in France, I'm sure.
Friedman:   Yes. I was living with a family in Boulogne. The husband was a
           fishing-boat captain. And Boulogne is the world's capital for
           mussels. So I had mussels smothered in loads of butter at night
           and gained lots of weight. Thankfully, though I still love
           mussels, I left the French way of cooking behind.
                 I finished at American University with a master's degree
           in 1966, at which time I didn't know exactly what I wanted to
           do. I was approached by the Coast Guard to become a Coast Guard
           officer, which I seriously considered.
                 I had been getting a Peace Corps bulletin for returned
           volunteers, which came every month or so. And at this very
           juncture of my life, the issue that was delivered to my
           apartment in Washington had an advertisement from CDC. They were
           looking for people who had lived in Africa, who could speak
           French, and who could fix a car.
Drew: This sounded like it had your name written right on it.
Friedman:   It just jumped off the page.
Drew: Really.
Friedman:   So it had a phone number in Atlanta. And this was in the days-I
           don't know if you remember these-when making a long-distance
           phone call was a big deal. Quite a big deal.
                 So I dialed the phone number and got a gentleman named Leo
           Morris on the phone. He was the assistant branch chief or the
           assistant chief in the smallpox program. He was coming to
           Washington the next day for some unrelated reason, and we made
           an appointment to meet.
                 We did. He interviewed me, and he hired me on the spot.
Drew: That seemed so fateful.
Friedman:   But I don't think at CDC today, anyone can hire anyone on the
           spot.
Drew: That's true, that's true.
Friedman:   And certainly not anyone without any public health background
           whatsoever, who could merely speak French, fix cars. I don't
           think such qualifications would get you anywhere today.
Drew: But it's the perfect combination.
Friedman:   Right. And Leo said, "You're hired." I don't know what
           bureaucratic shortcut he used, but that certainly was the case.
           And 2 weeks later, in July 1966, I was here in Atlanta. I flew
           down from Washington and rented an apartment-an apartment, which
           I believe is where this very building, Building 21, is now. If
           you're looking at the buildings, to the right of the building
           they just tore down, there was an apartment house. CDC was much
           smaller then.
Drew: Sure.
Friedman:   And there's still a pine tree growing right there, which was
           right next to my bedroom.
Drew: Oh, how funny.
Friedman:   The tree is still there; nothing else.
Drew: That's funny.
Friedman:   In any case, I was the closest person at CDC to the office. We
           met every day in the auditorium, which has just been torn down.
           And I literally awakened at 10 to 8:00 and would be sitting in
           the place where we had our training course 10 minutes later.
Drew: You had a really easy commute.
Friedman:   I had an easy commute. The apartment became a motel later.
Drew: Didn't CDC take it over and have offices there?
Friedman:   The motel closed, and there were CDC offices there. Through the
           '80s. And it was only in the '80s, I believe, or the early '90s
           that they built Building 21. But, thankfully, did not cut my
           tree down. I have a picture of me in front of it in 1966.
            Anyway, I began at CDC as a trainee in the Smallpox Eradication
           Program in July '66. Leo Morris, the guy who hired me, was my
           boss.
Drew: And you were in the public health advisor series?
Friedman:   Yes. There were 4 of us hired through this Peace Corps
           advertisement: myself, Jean Roy [Jeannel A. Roy], Tony Masso
           [Anthony R. Masso], and Mark Pointe, all of whom are going to be
           present at the reunion.
                 And the others-I think all of them-were public health
           advisors for the VD [Venereal Diseases] program, the VD branch,
           who had been chasing syphilis up and down the streets of New
           York City.
Drew: Yeah, [looking for] the contact persons.
Friedman:   It was felt that their expertise in that regard would be useful
           in smallpox. The 3 other guys and I who were coming from the
           Peace Corps did not have that expertise, but we knew the
           language and other things, fixing cars. Tony was with the Peace
           Corps in South America somewhere. But Mark, Jean, and I had all
           been in Africa and all spoke French.
                 Anyway, we started a training program here in Atlanta,
           which went on for several months. We were taught epidemiology,
           the epidemiology of smallpox in particular, which was very
           simple, actually, in the scheme of things in the world of
           epidemiology; and administration, how the government works.
                 We would be going to 19 countries. The majority of them
           were French-speaking countries, French colonies in West and
           Central Africa.
Drew: And did you know ahead of time which country you were going to go to?
Friedman:   Not at the very outset. When the program began, I think none of
           us knew, although I assumed, having learned French, I'd be going
           to a French country. At some point during the training course,
           which went on for 3 months, we were told. Originally, I was to
           go to Niger, and then, for various reasons-I forget what they
           were-I was told I would be going to Mali.
                 In most countries, we had both a medical officer and what
           were called operations officers, of which I was one. Our jobs
           were to assist the medical officer with the epidemiologic work-
           ups of smallpox outbreaks. More importantly, we were in charge
           of the logistics of the whole enterprise because the people who
           organized the program-D. A. Henderson [Donald A. Henderson], Leo
           Morris, Henry Gelfand, Rafe Henderson [Ralph H. Henderson], and
           others-wisely realized that smallpox was not so much a medical
           problem as a management and logistics problem.
                 The means for fighting smallpox were mostly known, not
           totally. Its epidemiology is very simple. Vaccination is an
           absolute preventive measure for varying periods of time. It's a
           simple disease epidemiologically in the sense that only human
           beings are the reservoir, meaning the virus doesn't lurk in
           water or in insects or in the environment in general. The virus
           is only found in humans, which makes a huge difference. Once you
           interrupt the chain of transmission from human to human, you can
           stop the disease in its tracks, which had been done in much of
           the world by 1966. The major foci, or the focus-I'm not trying
           to impress you-
Drew: Hey, I'm already impressed. It's okay.
Friedman:   Remaining in the world were foci in Brazil and East Africa,
           which was variola minor; an attenuated form of smallpox, and
           variola major, the real smallpox, with a 25% death rate, in West
           and Central Africa, the Indian subcontinent, and Indonesia.
           Almost all other countries had eradicated smallpox through
           vaccination activities. And it was, of course, eradicated in
           countries with the best-and I'm going to use this word loosely-
           management.
Drew: Sure.
Friedman:   So, naturally, in developed countries, they had mass-vaccinated
           enough of the population years before that it never really even
           got a foothold.
            Well, we had it in the United States, I guess, in great amounts
           in the 19th century. In the 20th century, there were just
           sporadic outbreaks. I remember as a child in New York City,
           there was a scare, around 1947, right after the war. I think
           there were a couple of cases of people coming from other
           countries where it was endemic. There were 1 or 2 cases in New
           York City. But the entire city got vaccinated immediately,
           including me. I remember it well as a child.
            I believe the last cases in the United States were in the very
           late '40s, I think in Texas. They might have been imported cases
           from Mexico. I don't remember exactly.
                 In Europe, there was an outbreak in the '70s in Yugoslavia
           of some Muslims. I believe it was involved pilgrims from Mecca
           to Yugoslavia.
                 Most cases outside the endemic areas I named were
           imported, usually traveled from an endemic area. Mecca was a big
           point for the transmission of many communicable diseases because
           masses of people gathered there. But there were other areas
           where smallpox cases would come from.
                 Anyway, I went to the training course, and I was assigned
           to work under a medical officer named Pascal James Imperato,
           known as Pat, who's going to be here also. In fact, he and his
           son are staying at my house. Pat and I went to Mali. I went in
           December of '66 and Pat a month or so later.
                 And the original strategy for eradicating smallpox in West
           Africa was to use mass vaccination of the population with jet
           guns.
Drew: Right.
Friedman:   Now, you've heard of these. They were developed by the military
           to quickly vaccinate the recruits, I guess anyone in the
           military.
Drew: Were these the ones that were powered, that required electricity??
Friedman:   Mali had a measles control program, also directed by CDC
           people, including Rafe Henderson, that began a year or so
           before; it used the military jet guns. And the jet gun consisted
           of a thing that looked like a gun, 2 hoses, and then a pump to
           pump hydraulic fluid into it and charge it, to load it, if you
           like, against a spring. The military once had an electric pump,
           which ran at 110 volts US current. To use the military jet guns
           in West Africa, you had to use a transformer and plug them into
           the wall, or, in this measles campaign, which predated smallpox,
           they had International American trucks with a refrigerator and
           generator mounted on the back. The generator generated 110
           volts, and they could use the electric guns in the field. This
           was all very unwieldy. The trucks would break; the generators
           would break. The electric pumps were very well made, made on a
           military, I believe, cost-plus basis so they were very solid.
           And the guns themselves rarely broke.
Drew: It was all the other things they were connected to?
Friedman:   Yes, the refrigerators, the trucks, even though Internationals
           are very good trucks.
                 They decided, wisely, that the electric guns weren't the
           way to go with smallpox, although we had a number of them in
           Mali. We assigned those to fixed health facilities, where they
           could plug them in the wall and transform them.
Drew: Where people could come to you.
Friedman:   Yes. This was mostly in the capital city.
                 Everywhere else in Mali, and everywhere else in West
           Africa, they used something called the Ped-O-Jet. It was the
           same gun part, upon which you put a bottle of vaccine and a
           needle. But instead of the pump on the ground, the 2 hoses
           coming to it being powered electrically; it was a pedal. The
           operator would step on the pedal-and I'm making a stepping
           motion.
Drew: Yes, right.
Friedman:   I'm telling the recorder that.
Drew: Please note.
Friedman:   And it would charge the gun, and the bottle of vaccine, of
           course, would be on the top. And then you pulled a trigger, and
           the vaccine would be injected forcibly into the skin of the
           vaccinee.
                 We had 2 types of nozzles on the guns. One was for
           intradermal smallpox injections, right on the top of the skin,
           and one for the measles vaccine, which was intramuscular, where
           it would go straight in as if it were a needle. Smallpox, you
           just deposit the vaccine on the surface of the skin and then
           prick the skin, normally with a needle. And this nozzle on the
           jet performed that function.
                 Unfortunately, the Ped-O-Jets were not made for the
           military. They were made for CDC by a firm in New York, and I
           don't think they were up to the same quality level. The guns
           would break-not so much break, as their internal valves and
           springs would wear out or get stuck. The nozzles would clog, for
           which we had special wires to ream them out. And especially the
           pedal, the pedal pump. I think they were made of aluminum with
           Teflon O-rings acting as piston rings. And this aluminum, being
           a soft metal, would wear out very quickly. Being an ex-mechanic,
           I had to fix them all the time, although I trained Malians to
           work on them, which is not very difficult.
                 And we spent a lot of time fixing these Ped-O-Jets. In
           fact, in Mali, we had 1 guy, a vaccinator, assigned full-time to
           work on Ped-O-Jets that were being used out in the field. So we
           had to transport them back to the capital to have this guy work
           on them. The simple repairs could be done in the field. But any
           time the pedal pump broke, you had to send it in. You had to re-
           machine the whole piston when that happened.
Drew: Sure. Was this whole process of doing the foot stroke on the pedal
           and shooting the gun difficult to coordinate?
Friedman:   Yes. That's a good question. In the French-speaking countries,
           we were very fortunate. The French had set up decades before
           something called a Service des Grandes Endemies (SGE), which in
           English is the Endemic Disease Service. It consisted of  mobile
           teams of male equivalents of registered nurses, which in French
           are called Infirmier d'Etat, which is literally "state nurse,"
           but it really means registered nurse. These are very high-level
           people with excellent training.
                 These groups of Africans would go in the bush, as we
           called it in Africa, on vehicles, sometimes walking or on horses
           or whatever, and attend to the public health needs of the
           population on a scheduled basis.
Drew: Making rounds in different areas?
Friedman:   Yes. And it was run as a military service. The workers in it
           had ranks, and they were, by and large, headed by French
           military doctors with military ranks. And under them were-it
           sounds very racist today-what they called in French Medecin
           Africain, which means African doctor. These were Africans
           trained in the university in Dakar, Senegal, to be medical
           doctors, but on a lower level. Shall we put it this way: they
           received less training than a medical doctor in France. So the
           heads of the Endemic Disease Service were usually the French
           medical doctors, and sometimes the French medical officers were
           in charge of actual teams. But, more frequently, they had what
           they called these African doctors, who, in my opinion, were
           superb people in the field. They really knew medicine on a field
           level. But, in fact, when you were sick, you didn't go see one
           of them. And they really had good training.
Drew: Well, it sounds very systematic, too.
Friedman:   It was very systematic. And they had a load of military
           [unclear].  Below them were the nurses, the Infirmier d'Etat,
           the male nurses. And below them were other ranks, vaccinators
           and so forth.
            Everyone had a rank. And these teams were, as I say, run in the
           military way. A team would line up in the morning in front of
           the Medicin Africain, or the senior guy on the team, to show
           their fingernails and show that they had cleaned them the night
           before. Etc. etc. It sounds colonial and semi-racist, but it
           worked. They actually eradicated sleeping sickness.
Drew: Great!
Friedman:   The formal name of sleeping sickness is trypanosomiasis, and
           the Africans used to call it the trypano service, service de
           trypano. And over the years-I think this began after World War I-
           they added other conditions and other diseases to the service,
           among which was treating lepers. They had lepers who would wait,
           for example, under a certain tree every month to get a drug
           called, I believe, Lomidin, if I'm not mistaken. I may have the
           names of the drugs wrong. So the guys on the teams would refer
           to them as "my lepers."
Drew: Because they'd meet with the same people on a regular basis?
Friedman:   Yes. The leper had to wait by a tree, by a bush, or on the side
           of the road, or a certain spot every month. The team would pass
           and give him his drugs. And they managed to control leprosy.
                 I remember going with some of these guys in the field, and
           you'd see some leper walking down the road. He'd say, "That's
           one of my lepers!" They knew them personally.
                 They treated leprosy. They started vaccinating against
           yellow fever, with BCG against tuberculosis, which was never
           used in the United States. They'd treat malaria patients.
                 When I got there, we wedded our resources-our trucks, our
           jet guns, and our smallpox and measles vaccine-to the Endemic
           Disease Service.
Drew: You kind of integrated into that existing system?
Friedman:   Exactly. And at one time, they were doing 5 vaccinations at
           once. They were looking for malaria, leprosy, sleeping sickness.
           Of course, there was smallpox, measles, BCG, yellow fever . . .
           What was the fifth one? I don't know.  There was a fifth one.
            They'd go into a village. They'd announce that they were
           coming. They'd send a runner or something. They'd say, "We're
           coming next week," or whatever.
           Believe it or not, the team would arrive in the village, and the
           villagers would be lined up by age and sex.
Drew: Wow!
Friedman:   I mean, this was fabulous! The head of the team would climb on
           the top of a truck and make sure everybody was lined up. They'd
           go to the whole village. I've seen this; it's almost
           unbelievable.
                 And the villagers were lined up by age and sex because
           each cohort of people and each age group got different vaccines
           and different treatments. If the teams were looking for sleeping
           sickness, they'd feel under the chin for swollen glands or
           something. (I think that was for sleeping sickness. These are
           other diseases I didn't know much about.)
            And these guys dealt with everything. They'd feel everybody.
           They'd palpate under the chin and they'd feel for sleeping
           sickness and leprosy.
                 We had a vaccinator arranged on each side of every person,
           and they'd get different vaccinations in each arm.
Drew: And the indigenous people apparently were very cooperative and
           willing?
Friedman:   Yes. And this operation was run like the military. The village
           chiefs were, of course, [unclear], and they loved us, and the
           people loved us.
                 Anyway, that's how we did our smallpox vaccinations in
           Mali, and it worked very well.
                 And the chief of one of these teams was a very senior guy.
           He'd climb on the top of the truck and start barking orders, and
           they'd actually obey them.
                 Anyway, Pat Imperato, the doctor I worked with in Mali,
           was an anthropologist also. He had actually written books on
           African culture and stuff.
                 Mali was very complicated because there were nomadic
           peoples in the country in what was called the delta of the Niger
           River, which is a big swamp area. It's not a delta at the mouth
           of the river at the sea; it's a delta in the middle of Mali, in
           the desert area, where the river would just spread out into a
           big swamp 100 miles across and then re-form as a river 100 miles
           later. There were nomadic cattle keepers in this area. And one
           of the major challenges we had was how to vaccinate those
           people.
                 So Pat, the doctor I worked under, studied them and
           figured out that they moved with their cattle in different ways
           and in different directions.
Drew: There was some pattern?
Friedman:   Yes, there was a pattern to their movements.
Drew: It wasn't just like a random kind of thing.
Friedman:   No, not at all. In fact, he did this along with Malian
           colleagues who knew all this. Pat sort of systematized their
           movements, on paper, and figured out how to position these
           vaccination teams in order to get these people when they were
           accessible. I think at certain times of the year they gathered
           in larger groups when the river got dry, which would be in April
           and May, just before the rainy season began. They'd sort of come
           together in a much smaller area in large numbers, where the
           remaining water in the river was present, where the cattle could
           graze and water. So Pat figured out that's the time of year when
           they should vaccinate the nomads.
                 The word for their movements in French was called
           transhumains [sp.], trans humans. I'm sure there's an English
           equivalent word, but I don't know what it is. I've never talked
           about this topic in English. But Pat was studying that. In any
           case, we vaccinated the area.
Drew: And did you have the same degree of cooperation?
Friedman:   Probably a bit less among these nomads. Not living in villages-
Drew: And kind of not having the structure of like a chief per se-
Friedman:   Exactly. That's an excellent question. I didn't even think of
           that. Not living in villages, they were much less easily ordered
           about, if you like. In fact, you couldn't order them about. They
           did their own thing with their cattle. And that was the
           challenge. And so the normal tactics used in villages had to be
           modified.
                 I would suggest you alert the interviewer who's going to
           work with Pat to ask him about vaccinating the nomads in the
           Niger delta. He's a very serious anthropologist. He's written
           books about this. He'll talk your ear off about it.
            All right. So we finished vaccinating Mali.
                 By this time, I had been there 2 years. It was September
           or October of 1968, and I was transferred to Gabon in Central
           Africa, which is around and below the [unclear] of Africa. It's
           a totally different country from Mali, which was semi-desert
           with many logistical problems.
                 I'd spent a lot of time in Mali working on trucks, fixing
           them, and fixing jet guns, and doing a little bit of
           epidemiology on smallpox outbreak investigation. We did have a
           couple of smallpox outbreaks.
                 When I went to Gabon, there was no smallpox, and my job
           was very different. First of all, there was no American medical
           officer there. I was on my own. I was working under a French
           military medical officer named Jean Claude Jeel [phonetic].  I
           was sort of his advisor on smallpox and measles vaccinations.
                 There, I got involved in surveillance, looking for
           smallpox. I also did maintenance for the jet guns and the
           trucks, although the French in Gabon and my predecessor in
           Gabon, Mark LaPointe, had set up an ongoing training course
           whereby the French and the Gabonese trained people on jet guns,
           so I didn't have a lot to do with jet guns. And I didn't have a
           lot to do with trucks. In Gabon, which was a much more
           economically advanced country than Mali, there were lots of
           garages in various towns, and it was possible to get things
           repaired. We didn't have to have our own mechanics, as we did in
           Mali, working on the trucks. If a truck broke, you'd move it to
           a garage and they'd fix it.
                 I learned a lot about surveillance, but I didn't have a
           lot to do, really. I mean, besides surveillance, there wasn't
           much. Plus, in May of '69, we achieved an interruption of the
           transmission of smallpox in West Africa, and I arrived in Gabon
           in late '68. So there was really less of a threat of smallpox
           transmission anywhere in West Africa. We were still looking for
           cases.
                 I stayed in Gabon from late '68 until April of 1970. So I
           wasn't there all that long, 18 months.
                 And then 2 things happened. Personally, I got married to
           my first wife, Lindsey Craper. She's British and was a professor
           at a university in Ghana. We met at a party given by George
           Lythcott, who was our CDC regional smallpox director. George
           lived in Lagos, Nigeria, where I went for a meeting in May of
           '69. Lindsey was a friend of George and his wife Jeannie.
           Lindsey was at the party, too, visiting Lagos from Ghana. So
           anyway, Lindsey and I met at this party. And, to make a long
           story short, a year or so later, we got married.
                 Interestingly enough, Jean Roy told me, the Jean and Betty
           Roy told me - you have to confirm it with him - that they met at
           the same party.
Drew: Oh, how funny!
Friedman:   You'd better confirm it with him.  But I believe . . .
Drew: Was it a New Year's Eve party, by any chance?
Friedman:   It was in May of '69, when we had a big meeting in Lagos.
Drew: Yeah, so it wouldn't have been New Year's Eve.
Friedman:   No, because we had achieved . . .
Drew: Because I may be mistaken.  I was thinking that Betty told me that
           they met at a New Year's Eve party.
Friedman:   A New Year's Eve party.
Drew: But I may be mistaken.
Friedman:   I may be mistaken.  One of us is mistaken.
Drew: Yeah, hey.
Friedman:   Anyhow, I think Betty knows.
Drew: It still sounds like a nice situation.
Friedman:   Betty knows.  If Betty said it was New Year's Eve . . .  Maybe
           it was at George's house for a different party.
Drew: Yeah, yeah.
Friedman:   So, anyway, Lindsey and I got married, and my term in Gabon
           ended, and it was decided there was no need for any further CDC
           operations overseas in Gabon.
                 But Nigeria had been the site of the last outbreaks of
           smallpox. It was a very large, very populous country, and it was
           felt we should really do much more intensive surveillance in
           Nigeria. Nigeria had just reorganized itself politically, the
           entire country. Instead of large regions, there were now states-
           I think there were 11 or 15 or something like that. And they
           wanted an operations officer in each one of the states to be in
           charge of the surveillance efforts and continue with mass
           vaccinations (although, at the time, we were switching away from
           mass vaccination).
Drew: And Nigeria was colonized by the British?
Friedman:   Yes. It was an English-speaking country. But my first
           assignment, Gabon, was French-speaking, of course. Nigeria is my
           first English-speaking country.
Drew: My son says that the health care systems left behind by the
           respective colonial powers were somewhat different in terms of
           how well or maybe not so well they worked.
Friedman:   Exactly, very different political and health structure in
           Nigeria from the French, ex-French colonies like Mali and Gabon.
                 Anyway, I was assigned to Kano state in northern Nigeria.
           It's at the very northernmost part of Nigeria. So my new wife
           Lindsey and I moved to Kano, where I was assigned to what was
           called the Epidemiology Unit in the Ministry of Health of this
           state of Kano. My boss was the chief medical officer of the
           ministry, Dr. Patel; he was Indian.
                 Northern Nigeria is an interesting area.  The people are
           Hausa-that's the name of the ethnic group; it is a very large
           ethnic group. And the Hausa language was spoken all over that
           part of Africa, even among people who were not Hausa ethnically.
           It's a much simpler language than the languages further south in
           Africa in that it's Hamitic. It's more like Indo-European
           languages. So foreigners tend to learn it to a greater or lesser
           extent. My wife, Lindsey, learned it perfectly. Her field is
           linguistics. I learned it a bit, enough to talk to villagers.
                 In any case, our job was continuing mass vaccination,
           although, as I started to say, we were switching to what was
           called the surveillance-containment approach to eradicating
           smallpox. Instead of vaccinating everyone, we'd merely do
           surveillance for smallpox outbreaks. When we found an outbreak,
           we'd do what was called ring vaccination around the outbreak
           area, including the immediate contacts of each case. Eventually,
           this strategy was adopted for the rest of the world, especially
           in the Indian subcontinent. And that was the strategy that
           eradicated smallpox.
            In densely populated countries, including northern Nigeria,
           mass vaccination really couldn't work. It really couldn't get
           everybody, get enough of a herd immunity whereby by the disease
           transmission would be interrupted, especially in India. You
           could never mass vaccinate there.
                 So, in any case, we started doing surveillance-containment
           in Kano state and continued vaccinating, continued looking for
           cases. We never found any.
                 All the while, we were doing vaccinations against measles
           also. The problem with measles was the vaccine. It was much less
           heat stable than the smallpox vaccine. The measles vaccine had
           to be kept frozen. With the smallpox vaccine, we learned that
           (although officially it was supposed to be kept cold) because it
           was freeze-dried and very heat-stable, you didn't have to keep
           it cold. It stayed potent. You couldn't have it out in the sun,
           but as long as you kept it covered, it would stay potent for a
           long time. But with measles vaccine, in spite of our best
           efforts, I'm certain that there were occasions where we were
           vaccinating with impotent vaccine because the cold chain, with
           the fridges and little cooler boxes that the vaccinators carried
           to keep the measles vaccine frozen, just broke down.
Drew: Sure.
Friedman:   We did control measles in certain countries. Gambia was 1
           example. But in other areas, we had greater or lesser success
           with measles control. It was never thought we'd eradicate it,
           although they did in Gambia for a while.
                 In any case, I spent 2 years in Kano, which were
           delightful. I was newly married. It was a very large and well-
           developed city with an international airport, direct flights to
           London and elsewhere in Europe.
                 I joined a British club, which I thought I'd never do,
           learned to play squash; I really had a nice time in Kano. I
           mean, I worked very hard, but the state of Kano was very heavily
           populated, and the area was rather small. So I rarely had to
           spend the night out in the bush as I did before.
Drew: You could do what you needed to do on certain day trips?
Friedman:   Exactly. And so I slept at home most nights. And my older
           daughter, Laraba, was born. Laraba is a Hausa name for girls
           born on Wednesday, which we had chosen from the pantheon of
           girls' names-7 of them, one for each day of the week; well,
           there's more also-before we knew, of course, what day she was
           going to be born on. It was a 6:1 bet. She was, in fact, born on
           Sunday, but .she still wound up being named Laraba.
Drew: A very pretty name.
Friedman:   Which is the name she retains to this day, of course. She is
           now 35 and living in London.
                 What else happened in Kano? We had a very congenial work
           experience there. The epidemiology unit that I worked with was
           headed up by a man named Al-Haji Mohamed Kozoray, he and I
           became quite good friends. We worked together well. Everything
           was nice in Kano. I liked it.
Drew: And so your eldest child basically was a toddler in Kano.
Friedman:   She was an infant. She was actually born in the U.K because my
           wife was English, as I mentioned. Laraba came to Kano in
           northern Nigeria at the age of 2 weeks. And we stayed there
           until April of '72, which was the end of my West African
           sojourn.
                 I went on to do smallpox eradication in Nepal, which is
           not the topic at hand. So I guess I ought to end right here.
Drew: Well, it's a shame because I'd love to hear that story too.
Friedman:   Oh, really? I'd be glad to tell you that one. Any other
           questions?
Drew: Well, are there any other things that you can think of about your
           experiences that you'd like to share?
Friedman:   The only thing I could say about my experience is that it
           introduced me to public health. As I said at the outset, it was
           not my field at all, unlike the other operations officers who
           had come from the VD branch.
                 Eventually, after living in Nepal and then the
           Philippines, where I was in the Expanded Program on
           Immunizations, I came back to CDC in 1978. I joined the Division
           of Reproductive Health and spent 25 years working on
           contraceptive-prevalence surveys, largely in foreign countries.
           But towards the end of the 25 years, I was also working on
           behavioral risk-factor surveys on Native American reservations.
           We had monies from the Indian Health Service to run surveys on
           Indian reservations similar to those I had done in foreign
           countries on contraception. We looked at behavioral risk
           factors. As you know about Native Americans, smoking, diabetes,
           and other conditions related to behavior are important.
                 So I would say my last 5 years at CDC, before I retired in
           2003, were spent working on Indian Health Service stuff,
           surveys; and they paid half my salary. So I had a rather diverse
           career.
Drew: It sounds really interesting and rewarding.
Friedman:   I think so. And I think I was lucky. As a public health
           advisor, I was never pushed up into administration like so many
           people were. I remained in science my entire career. I never had
           to supervise anyone really, which I found much more enjoyable
           than working in administration, which is not my cup of tea.
            So I had a very rewarding career. I always liked going to work
           in the morning. Never in my wildest dreams, before coming to
           work at CDC in July of '66, would I have thought I'd work in
           anything having to do with health, public health, epidemiology,
           survey data analysis, and everything else I did here. So I
           really had a very rewarding career at CDC.
Drew: That's great. And that's very interesting to hear about, and I really
           appreciate it.
Friedman:   You're welcome.
                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

Mr. Jay Friedman with Dr. David Sencer &amp;amp; Maddie Maddie
Transcribed: January 2009



Maddie:     My name is Maddie Halendonie [inaudible name0:00:12]  and  I  am
      student of Emory College, and I am sitting here  today  with  Mr.  Jay
      Friedman. It is March 31st, 2008 and we are in the CDC.

      So welcome! Thank you for coming.

J. Friedman: Thank you for having me.

Maddie:     Just to get started, if you could tell us a  little  about  your
      background, your hometown, where you come from, your education?

J. Friedman:     I was born in New York City at 123rd Street,  and  grew  up
      in the Borough of Queens, went to college at Florida State  University
      and then joined the Peace Corps where I  spent  two  years  in  Sierra
      Leone, West Africa. Following the  Peace  Corps  I  went  to  graduate
      school at American University  in  Washington  D.C.  where  I  studied
      International Economics and Languages.

      Towards the end of my two-year course I was reading a  Notice  in  the
      Return Peace Corps Volunteer Bulletin which  asked  for  ex-volunteers
      who had lived in West Africa, who could speak French  which  I  could;
      and who knew how to fix a car, which I also could,  having  worked  my
      way through college as an auto mechanic at an Oldsmobile dealer in New
      York. Well, the notice was from the Centers for Disease Control asking
      for people with those qualifications to go back  to  West  Africa  and
      work on the Smallpox Eradication  Program  and  it  seemed  like  that
      fitted me perfectly. So I made a phone  call  to  the  number  in  the
      Notice and spoke to a person called Leo  Morris.  He  was  the  Deputy
      Branch Chief or Deputy Director of the  program  who  happened  to  be
      coming to Washington the very next day where we met, and he  hired  me
      on the spot, which I am certain is no longer possible at CDC, to  hire
      anyone so-shall we say unknowingly, or without knowing all  that  much
      about him. Today there  are  all  kinds  of  background  and  security
      checks.

      Anyway it worked out well. Later that year which was 1966, on July 1st
      I reported  here  in  Atlanta  and  went  to  work  for  the  Smallpox
      Eradication  Program  whose  Director  at  the  time  was  Dr.  Donald
      Henderson - D.A. Henderson, and whose deputy of course was Leo  Morris
      aforementioned. Dr. Henderson not long afterwards left to head up  the
      smallpox program at the World Health Organization in Geneva. Meanwhile
      I joined roughly 40 other people, newly hired, some of whom  had  been
      CDC employees, others like me  were  not,  to  go  through  a  -  I've
      forgotten how many months  exactly  -  about  three  or  four  months'
      training course in epidemiology, about which I knew nothing, about the
      characteristics of smallpox which I also knew nothing about.  We  also
      learnt quite a bit about the culture and the politics, if you like, of
      West Africa which I knew a bit more about. We also were sent - we were
      divided into two: medical officers and  what  were  called  operations
      officers. I was an Operations Officer and the operations officers were
      also sent to the Chrysler Corporation Service Training School, it  was
      somewhere in South Atlanta, I  think  on  Moreland  Avenue,  I  forget
      exactly; and we went through a course learning how to  work  on  Dodge
      pickup trucks with which we were going to be equipped in West  Africa.
      The Medical Officers studied more epidemiology than we did.

      Anyway, following a couple months of this, those of us going to French-
      speaking countries, of which I  was  one  -  I  was  assigned  to  the
      Republic of Mali; stayed behind  I  think  and  went  through  a  very
      intensive French  language  course.  I  knew  a  lot  of  French,  but
      obviously I didn't know everything and learnt a  lot  at  this  course
      which was run by Emory  University.  Then  in  December  of  '66,  the
      medical officer I was working with in Mali, Dr.  Pascal  Imperato,  we
      left for Mali and we started working on eradicating smallpox.

      Mali was a difficult country among the - I think it was  20  countries
      we were working on in Western Central Africa - because  in  the  early
      60s a Leftist Government took over from the  French  Colonists  -  the
      French Colonial Power; and they were very close to  the  Soviet  Union
      and North Korea, and all the Communist countries at the time. The fact
      that this program was financed by the United States, specifically  the
      U.S. Agency for International Development meant it wasn't easy for  us
      to work at first. But Dr. Imperato and I, if you  like,  made  friends
      with all the principal characters we had to work with,  and  gradually
      we gained their confidence and we didn't have any further problems.

      Initially in West Africa the approach  was  called  mass  vaccination.
      Smallpox being what it is,  I  am  not  going  into  detail,  but  the
      reservoir is human beings. There is no animal or water or other insect
      borne way of transmitting the disease, it's human to  human,  and  the
      vaccine works. So the idea was that we vaccinated a certain proportion
      of the population which the doctors in charge of the  program  thought
      would be 80%, we'd stop the transmission of human to  human  smallpox.
      Mali was very difficult because through the  country  runs  the  Niger
      River. It's called in French the buckle of the Niger River,  the  bend
      of the Niger River, which creates a large swampy area in  which  lived
      the Nomadic cattle herders, and these people moved with the rising and
      the falling of the river depending on the various seasons, rainy,  dry
      and cold are the three  seasons  of  the  year  there.  Dr.  Imperato,
      fortunately, was an amateur anthropologist which I believe was one  of
      the reasons he was selected to work in Mali. He studied  the  movement
      of these people quite thoroughly and actually  wrote  some  scientific
      papers on it, and figured out where vaccinators should be  at  certain
      times of the year, etc.

      So we began vaccinating in this area, which is right in the middle  of
      Mali, very difficult to access. We had to use boats and other means of
      transport. At the same time, besides mass vaccinating our  other  task
      was to look for smallpox cases. This was done by  having  or  alerting
      local health workers all over the country to  alert  the  Ministry  of
      Health in Bamako, the capital, if they found or noticed  any  smallpox
      cases, and we had an agreement that if smallpox cases  were  found  we
      would go out  there  and  investigate,  being  trained  of  course  in
      recognizing smallpox and knowing  how  it  transmitted  etc.  etc.  So
      meanwhile there were cases of smallpox in the country in Mali, and  we
      investigated several outbreaks I remember, and we kept vaccinating  at
      the same time.


      Meanwhile, one of the medical officers in  the  program,  Dr.  William
      Forge who later became Director of CDC in Eastern Nigeria had come  up
      with another methodology  for  attacking  smallpox.  That  was  called
      surveillance containment. I believe, Dr. Sencer can correct me if I am
      wrong, he felt that you really couldn't vaccinate enough people purely
      to stop the transmission, given  the  various  problems  with  Nomadic
      populations and that sort of thing. The best approach would be just to
      look for cases and put vaccination on the backburner if you  like  and
      contain every outbreak with various strategies, one of which was  Ring
      Vaccination Containment, that  is:  you  vaccinate  the  people  right
      around each outbreak and check everyone  coming  in  and  out  of  the
      outbreak area with people called watch guards, and sooner or later you
      would interrupt the transmission, and even if there were  unvaccinated
      people, the fact that you interrupt the transmission, since it's  only
      transmitted from human  to  human,  that  eventually  you'd  stop  the
      transmission of smallpox; and in fact this is  the  way  smallpox  was
      eradicated.

      So I spent two years in Mali, I was there till September of 1968. Then
      I was transferred to Gabon, the Ex-French  equatorial  Africa.  It  is
      around the bends of the armpit of Africa if  you  like.  A  very  rich
      country on the North-South Coast; it is an oil producer and all  sorts
      of minerals, and it's in a part of Africa that is very under-populated
      for various reasons: issues with fertility and venereal disease,  that
      sort of thing. So the population there was very low and smallpox is  a
      disease that requires a certain density of population to transmit  and
      there hadn't been cases in Gabon for a long time. The reason  we  were
      working there was that it was surrounded by countries  that  did  have
      smallpox. Anyway, I spent about a year - almost two years in Gabon and
      didn't have a lot to do; actually we concentrated on vaccinating there
      because there were no cases. Gabon  being  a  wealthy  country  had  a
      Mobile Health Service called - it's in French, I'll translate  it,  it
      was called the Endemic Disease Service set up by the  French  military
      whereby health workers would be transported from village to village on
      trucks and they would treat people for various illnesses and  also  do
      five vaccinations at once, look for leprosy and sleeping sickness  and
      other diseases. Anyway I  was  an  advisor  to  this  Endemic  Disease
      Service for smallpox eradication; and I  forgot  to  mention:  in  all
      these West African countries we were also doing measles control.  This
      was also in Mali, I forgot to mention. The West Africans were  not  so
      much interested in smallpox eradication  which  was  a  public  health
      problem, but not, in their eyes, a major one. It was a  major  one  in
      our eyes as Americans and Westerners, because it  did  have  worldwide
      implications. But in West Africa they had many greater problems  among
      which was measles,  which  unlike  the  United  States  and  developed
      countries where it is a benign childhood illness, or somewhat  benign,
      in West Africa where children's immunity, or immunity  systems  are  a
      little weak because of malaria and other diseases they have.

      Am I on the right track Dr. Sencer?

Dr. Sencer:      You're doing fine, except move along a  little  bit  so  we
can get to India.

J. Friedman:     Okay, alright. Anyway we also gave measles vaccinations.  I
      was in Gabon for two years and then I was sent to Northern Nigeria  to
      the city Cano where I also spent two years. There was no  smallpox  in
      Cano either. In April of '72, I received  a  telegram  from  Dr.  D.A.
      Henderson who I mentioned earlier. He knew I was due  to  go  back  to
      Atlanta for CDC. There was a limit on the amount  of  time  you  could
      stay overseas. He asked me if I would be willing to  resign  from  CDC
      and go to work for the World Health Organization and go to Nepal where
      they needed an operations officer like myself, and I did.  I  resigned
      from CDC went home to New York for two weeks and then I was on a plane
      for Geneva where I went to an orientation course,  just  a  couple  of
      weeks, and then arrived in Katmandu, Nepal at the end of  April  1972.
      Nepal of course is in the part of the Indian Subcontinent where  there
      were lots and lots of smallpox, much more than  in  West  Africa.  The
      population is denser, those countries are somewhat less well organized
      than West Africa and vaccination levels were low.  They  had  constant
      endemic smallpox which kind of moved around the Indian Subcontinent in
      a big circle and the year I arrived, in 1972, the endemic  areas  were
      much further South in India. It was nowhere near Nepal which is on the
      Northern border of India. At the end of 1973 the big track of smallpox
      moved up to Northeastern  India  very  close  to  Nepal  and  we  were
      immediately  inundated  with  lots  of  cases.  We  had  adopted   the
      surveillance containment approach  and  I  became  busy  investigating
      outbreaks. I had as colleagues there, another operations officer and a
      medical officer.

      All the cases in smallpox practically were - every case was the result
      of cross-border travel from India to Nepal. That border is  open  like
      the US-Canadian border; people just walked back and forth. Some places
      you can't tell which country you are in  even,  and  we  had  lots  of
      cases, first in the Western part of Nepal, which was at  the  time  in
      the 70s, very underdeveloped. No roads at all from the capital  there.
      You had to drive to India or fly in a plane. There  were  even  places
      where there were airports but no roads. So the only  modern  means  of
      conveyance the local  population  had  ever  seen  were  airplanes  or
      aircraft and helicopters. They had never seen a car or  a  truck.  You
      had lots of anomalies like that there. This is 1973; I spent a lot  of
      time trekking in Western Nepal looking  for  smallpox  cases.  At  one
      point when I wrote this up which  is  part  of  the  smallpox  archive
      somewhere, I was flown to an airport in Western Nepal where there  was
      no road, and walked a couple of days to an outbreak area along with my
      Nepali colleagues, there were about five of  us.  We  found  that  the
      local smallpox people had contained the outbreak. They  had  done  all
      this ring vaccination that I mentioned, and we spent a day or so there
      and realized there was nothing more for us to do.  So  we  decided  to
      visit other neighboring districts and just look for cases.  There  had
      been no reports.  So  I  was  with  a  doctor  named  Benu  Bado  Kaki
      [inaudible name 0:17:16], who was the Deputy Smallpox Chief in  Nepal,
      and we started walking and after a day or so, he branched off  to  one
      district and I to another. I walked and walked for  several  days  and
      got to the  next  district  where  there  were  American  missionaries
      living. I spent several days with them and ate steak and mash potatoes
      and stuff like that which you couldn't get elsewhere in  Nepal.  There
      were no smallpox reports from this area. I then  walked  several  days
      down to the plains of Nepal which borders India,  a  very  flat  area,
      unlike the mountains in the rest of the  country;  and  spent  several
      days there also looking for smallpox along with local smallpox  staff-
      found nothing.

      Then the town I was in right on the border with India  had  a  once  a
      week plane service back to Katmandu. So I  bought  a  ticket  and  the
      plane never came. It only came as I said once a week.  I  didn't  know
      what to do. I was stuck in this place.  There  was  no  road  back  to
      Katmandu and I had no car with which to get home.  So  I  was  hanging
      around the airport and there was a very wealthy Nepali who belonged to
      the upper crust of society, who was there with a Land  Rover.  He  was
      also trying to get on the plane. He  had  been  hunting  elephants  or
      something, and I started chatting with him, and he said, "Well,  I  am
      going to drive to Lucknow," a big city in India several hundred  miles
      South of where we were, "and I am going to fly home from there and you
      are welcome to come with me," which I did and arrived  home  a  couple
      days later. I had been gone two weeks  and  essentially  had  fun  and
      really didn't do anything. So the World Health Organization -  well  I
      had done something, I had done  some  surveillance  but  not  anything
      concrete. The World Health Organization then got money for  helicopter
      charters which were very expensive; it was 400 Bucks an hour to run  a
      helicopter. For the next - this is in 1973; I was in Nepal  till  '77,
      for the next four years we used helicopters  to  go  to  these  remote
      areas where we could do what I did in two weeks in a day, just go  and
      come the same day, and since we had so much smallpox, the  circle  now
      moved a little differently in India such that now  eastern  Nepal  was
      full of smallpox.


      A third operations officer came, by the name David  Bassett,  who  had
      also worked for CDC, so we were four people actually working there and
      inundated with cases all the time. 1974 was the worst year  in  Nepal.
      It was also the worst year in India as I remember. The state of  Bihar
      in India which borders on Eastern Nepal was loaded with  smallpox  all
      throughout '74 into 1975 such that in - I am trying  to  remember  the
      dates here - November '74 I was asked to stop working in  Nepal  where
      we had things more or less under control and  spent  three  months  in
      India along with many other people. At the time the Indian  Government
      couldn't scare up enough people to work on smallpox. The problem there
      was so enormous, tens of thousands of cases, that they not only  hired
      young medical guys who had just gotten out of medical school I  guess,
      who've been studying public health; and non doctors, people like me we
      are called technical officers, but also CDC and WHO brought in  people
      to work on smallpox for three-month periods. Some of  these  were  ex-
      West African people who had done what I had done. Some of them I think
      knew  nothing  about  smallpox  at  all.  On  the  other   hand,   the
      epidemiology of smallpox is such that you can  teach  any  intelligent
      person in 15 minutes everything he has to know. As I said, it's  human
      to human, there's no other reservoir, in a day you  can  make  anyone,
      truly without too much exaggeration, an expert  on  smallpox.  So  CDC
      sent a lot of people, WHO recruited others in Europe, along  with  our
      Indian colleagues, we were an army. I can't tell you  but  my  job  in
      Bihar State in India was to be in  charge  of  paying  everyone.  They
      wanted a full time WHO employee in charge of the money and I  guess  I
      was one of the few. So I was in charge of paying hundreds  of  people,
      both Indians and non-Indians in Bihar State for which they gave  me  a
      suite in a very rundown hotel in the capital of Bihar, which is Patna.
      This was just a low-down dingy [inaudible 0:22:27] Indian hotel but it
      had a suite, and since I was in charge of all the money, I had a safe;
      they gave me this suite in which I lived in luxury essentially, but  I
      was very busy. We had an office there with a  number  of  people.  Dr.
      Larry Brilliant was in charge of the office, and believe it or  not  I
      was busy fulltime paying people.

      All these people in the field had to have  money  because  the  Indian
      Government Rules and Regulations were so Byzantine.  For  example,  if
      you had an official jeep and it got a flat tyre, you had  to  fill  up
      forms and get some senior  person  somewhere  to  approve  spending  a
      dollar to fix the flat. So WHO got a system going whereby everyone had
      an Imprest Fund they called it. What it meant was that you had $100 in
      your pocket to freely spend as you saw fit  to,  fix  flat  tyres  and
      grease the skids so to speak. So I was in charge of  replenishing  all
      this money. There  were  some  bizarre  scenes  with  all  the  money.
      Everything was in cash. Once a month I would get a large  cheque  from
      the WHO headquarters in New Delhi for $100,000 or something like this,
      I can't remember. It was still lots and lots of money, and I'd take it
      to a local bank there in Patna and deposit it. Then everyday I had  to
      go back to the bank and withdraw enormous amounts of cash.  It  is  in
      Rupees, I can't remember; say $10,000 everyday, something like that. I
      carried this in my briefcase, all this cash. Indian banks  being  what
      they are, it took sometimes three hours from the time  I  walked  into
      the bank and said I wanted this cash for them to count  it;  they  had
      guys sitting on the floor counting it - I'm  exaggerating  -  5  or  7
      people to sign out on this money and they would give it to me  wrapped
      in - the money is wrapped in pieces of paper and I'd stuff it all into
      my briefcase then walk down the street holding  it  unguarded.  Anyone
      could have walked behind and whacked me on the head and run away  with
      it, but nothing ever happened.

      Anyway I would get back to the office and spend the  day  passing  out
      money to people who'd come in to get it. I kept very detailed  account
      books. At the end of every month, they sent an  accountant  down  from
      New Delhi to go through my cash and my  cheque  books  and  there  was
      always some discrepancy of $1.00 or something  like  this  and  I  can
      never figure this out. The night before this auditor came; I'd  be  up
      all night going through the books trying to find out why there  was  a
      $1.00 discrepancy. This guy was an Indian, he'd spend five minutes, he
      would go through the books and say, "There's your $1.00;" after I  had
      been up till three in the morning trying to get it  straightened  out.
      Anyway I did this for three months-handled the money.

      Then I went back to Nepal where we still had some cases.  We  had  the
      very last cases. This was in early  1975,  February  1975,  which  was
      complicated by the fact that the King of Nepal, it was a new king  who
      had his coronation that very month and you couldn't  travel  anywhere.
      Meanwhile, we knew there was smallpox in certain  places.  To  make  a
      long story short, some of these cases  spread  indigenously  in  Nepal
      which hadn't happened before, because nobody could  go  anywhere.  The
      country was more or less locked down for  long  durations.  Anyway  in
      March and April '74 in the southeastern corner of Nepal,  we  had  our
      last cases, which were very well documented. Many photographs  of  the
      last three cases which was a husband and wife and a  child.  In  April
      '75 we had our last case and sent a telegram to  WHO  headquarters  in
      Geneva, I remember it.  The  telegram  read:  "D.A.  Henderson,  World
      Health, Geneva-No pox!" The signature was Nepal  Smallpox  Eradication
      Program. They still have it on file somewhere I guess. I stayed  there
      another two years. The task of the last two years was to look for non-
      existent cases. They had their last  case  in  Nepal,  I  believe  the
      following month in May; and in Bangladesh that August I think.  Anyway
      India, Bangladesh, Nepal, we  spent  the  next  two  years  until  '77
      looking  for  smallpox  and  we  had  armies  of  people   out   doing
      surveillance. I think in India I  read,  at  some  point  they  had  a
      100,000 people do surveillance for a week or two weeks.

Dr. Sencer:      More than that.

J. Friedman:     More than 100,000 people. Anyway there were lots of  people
      working on this. We looked for two years, didn't find  a  case.  There
      were lots of reports because we were offering rewards at  this  point.
      We were offering initially a reward of Rs.100 which at  the  time  was
      $10.00 or something, and then the reward was up to Rs.1000 which was a
      $100.00. Anyone who reported a case that turned  out  to  be  smallpox
      would get a small fortune by the standards  of  India  and  Nepal  and
      Bangladesh, and we got lots and lots of reports, many of which  turned
      out to be other skin rashes including chicken pox,  scabies,  I  don't
      know about some of the others; but we were all trained in  doing  this
      differential diagnosis and so was everybody else. All the  workers  at
      the lowest level, all knew about this. In fact  they  eventually  knew
      more about it than we did, the foreign advisors, which  was  the  nice
      thing about smallpox.  Nobody  really  knew  more  than  anyone  else.
      Everybody knew everything there was to know about  smallpox.  Remember
      my job during this period in Nepal, being  a  foreigner,  I  could  do
      things and go places around the bureaucracy in  such  a  way  that  my
      Nepali colleagues running the smallpox program couldn't.

      For example, I knew the Minister of Health when he was a young  junior
      doctor when I had arrived five years before. Literally I'd could go to
      his office, knock on his door wearing a T-shirt and jeans and  sandals
      and walk in and he'd greet me warmly.  No  Nepali  official  could  do
      that. That was the anomaly of being a  foreigner  in  a  country  like
      that, one of them. Anyway, at the end of  the  two  year  period,  WHO
      constituted committees for each country, Dr. Sencer was on the one for
      India, as I remember, who  would  come  to  the  country.  These  were
      usually very senior virologists and epidemiologists from various parts
      of the world. The committee that came  to  Nepal  was  headed  by  the
      Polish Minister of Health, whose name was  Yang  Kartuski,  and  there
      were other people. I remember there was a Japanese scientist who was a
      virologist and various others. I don't remember everyone, but I had to
      take these people around the country looking at the work we were doing
      and at the end of - they were there  for  two  weeks  in  Nepal,  they
      certified smallpox in Nepal as being  eradicated  and  this  coincided
      with Nepali New Year as I remember. Nepal calendar is April to April.


      They made this certification, they left, and then the head of  WHO  in
      Nepal and myself were invited for an audience with the King  of  Nepal
      which doesn't sound like much, but it was very rare for a foreigner to
      meet this guy, which I did. I have a photograph of  it.  Unfortunately
      he was the King of Nepal assassinated in the year 2000,  I  think.  He
      was a young guy, spoke beautiful English and I had  seen  his  picture
      everywhere for two years, but I had never seen him in the flesh. It is
      very funny, the WHO representative Veri[inaudible name 0:31:24]  Mills
      and I were leaving, and we said to each other, "He is a nice  guy,  we
      wouldn't mind drinking a beer with him or something." Anyway, a couple
      of months later I left Nepal. My work had been finished.  I  was  then
      transferred by WHO to the Philippines where I worked for  a  year.  In
      the Philippines I lived in the  Pasay  City,  traveled  all  over  the
      Philippines for  the  expanded  program  on  immunizations,  childhood
      vaccinations, somewhat related to smallpox which is quite different in
      many ways though. A lot of the work I  had  to  do  regarded  smallpox
      vaccine production, there is a big lab there - not smallpox -  vaccine
      production, no more smallpox. This was  diphtheria,  ptosis,  tetanus,
      and other childhood diseases. The lab  knew  nothing  about  how  many
      doses they had to produce. So a lot of my work was figuring  this  out
      based on my experience with traveling around the country  as  well  as
      getting reports from hospitals and doctors all over the place. I first
      learnt to use a computer there.

      I also traveled a lot in the Philippines, saw the country. It was  the
      only country I was in where outside the capital was nicer  than  being
      in the capital. Manila is a huge tropical city full  of  traffic,  not
      very pleasant. All these secondary towns and cities  there  were  very
      nice, I liked that. Anyway I spent a year and a half there and then  I
      came back to CDC, went to work in the division of reproductive  health
      working on first what was  called  Contraceptive  Prevalence  Surveys;
      looking at women of reproductive age in a population usually 15 to 44,
      sometimes 49,  and  looking  at  the  proportion  using  contraceptive
      methods: which one,  and  most  importantly,  of  those  not  using  a
      contraceptive method, why they weren't. I did that  for  a  number  of
      years. Then I did something slightly different which was contraceptive
      logistics. AID, Washington State Department, as part  of  foreign  aid
      distributes contraceptives all over the world-I worked with a group of
      people here at CDC and it was very similar to what I was doing in  the
      Philippines, figuring out how many contraceptive methods each  country
      needed, which ones, and when they should be delivered and all that.

      Next, since I had worked a long time  at  CDC  -  sorry  contraceptive
      prevalence surveys - excuse me, I am getting mixed up, along with  few
      other people in the Division of Reproductive Health, since we were  so
      called experts on surveys, got  some  money  from  the  Indian  Health
      Service to do  behavioral  risk  factor  surveys  on  Native  American
      Reservations in the United States. This was  looking  at  smoking  and
      drinking and car accidents and other stuff that Native  Americans  are
      prone to, to a point. In doing this, I traveled all  over  the  United
      States; went to some  areas  I'd  never  ever  gotten  to,  Idaho  and
      Northern Maine and lots of places where Indians live  which  sometimes
      you don't realize they are there. We even did a  survey  in  New  York
      City where there are 35,000 Native Americans. Having grown up  in  New
      York, I had no idea these people were there, and towards the end of my
      career, we are now in the 2000s, I started working again  on  maternal
      risk - maternal  health  surveys  including  contraceptive  prevalence
      mostly in Southern Africa and Jamaica. I worked  on  four  surveys  in
      Jamaica in the Caribbean  and  one  enormous  survey  in  Zimbabwe  in
      Southern Africa and then retired in January 2003, five years ago. Here
      I am. I'm having a good time being retired.

Dr. Sencer:      What was the most important thing that your  experience  in
      smallpox  [inaudible/low audio0:35:32]?

J. Friedman:     Well, it's easy. Achieving smallpox  eradication  in  Nepal
      where I had spent five years. It was the only country I came  to  call
      home, being there so long, and I liked it the best. I was  married  by
      this time and we had two kids who spent their  first  years  of  their
      lives there and  it  was  quite  an  achievement.  It  was  much  more
      difficult than West Africa, for lots of reasons, among which was  that
      the people didn't accept vaccination as readily as the West  Africans.
      There was a lot of epidemiology which I had learned pretty well, a lot
      of logistical problems. So it was very satisfying eradicating smallpox
      in Nepal. It was in West Africa also, but quite frankly it was  a  lot
      easier in West Africa in my opinion. That was the most rewarding thing
      I think.

Dr. Sencer:      One final question, Jay. What did you bring out of Nepal?

J. Friedman:     Personally, I learned a lot. I learnt  to  speak  a  little
      bit of Nepali. My wife and kids learned it fluently. I think I brought
      out mostly an ability to - I'm going to put it  in  very  metaphorical
      terms, speak to the Nepalese. By that I mean, I learnt their  rhythms,
      I got into their rhythms,  so  I  knew  when  to  appoint,  insist  on
      something, when to not insist on something, when to hold back, when to
      be a little more assertive. A lot of this I learnt from my boss who is
      a guy named Dr. M. Mitchell  Satyanathan[inaudible  name0:37:33],  who
      was Sri Lankan. He was in charge of smallpox there, as far as the  WHO
      people were concerned and he taught me a lot of that, being  an  Asian
      himself. He knew when to go along with what the Nepalese wanted to do,
      and at the same time when not to, and I picked up what I  learnt  from
      him from him - that's an oxymoron what I just said - and I think  this
      carried over to my later career where I was working  on  the  surveys,
      here back at CDC many of which were in foreign countries; I did lot of
      work as I mentioned in Jamaica and Zimbabwe, also in Senegal and other
      West African countries. I even went back to Nepal a couple of times as
      a foreign  technical  advisor  in  Family  Planning  and  Reproductive
      Health, and I think I was much better at doing this than when I was  a
      young guy in my 20s and 30s starting out,  when  I,  as  an  American,
      didn't really empathize with foreign cultures - not foreign - I mean I
      was used to England and France and other countries, but  dealing  with
      people in Asia and Africa, it's very different from dealing  with  the
      European or an American; specially different from being an American. I
      think I got pretty good at that.

Dr. Sencer:      Did you bring anything material out of Nepal?

J. Friedman:     Well, my younger daughter is an adopted Nepali orphan.  She
      is now 35 years old and married, but I guess  you  could  call  her  a
      material thing. I'm kidding of course; I think  she'd  laugh  at  this
      though. I also - you mean possessions? I  bought  an  antique  car  in
      Nepal, which I brought back here to Atlanta, which I drive  around  in
      still.

Dr. Sencer:      How antique?

J. Friedman:     It's a 1932 Ford which had belonged  to  a  Nepali  General
      who gave it to his daughter who gave it to  her  driver  from  whom  I
      bought it. I had it restored there and shipped  back  home  in  a  big
      crate.

Dr. Sencer:      How did you get it out of Nepal?

J. Friedman:     A local moving company who  is  the  agent  of  Allied  Van
      Lines here in the States made a big crate, this is before  containers,
      in 1975; a big crate as long as this area here.  They  drove  the  car
      into the crate and they  tied  it  down  with  chains  and  ropes  and
      everything, they had hooks on the top. We hired a crane, or they hired
      a crane, and lifted it up and went onto a truck. The truck  drove  the
      crate to Calcutta in India near a seaport; it was loaded on a ship, of
      course. The ship landed in Los Angeles and it was  loaded  on  another
      truck and came here to Atlanta. I  drove  it  out  of  the  crate-same
      crate.

Dr. Sencer:      The mythology is that you brought it out  on  an  elephant,
but you didn't?

J. Friedman:     No, but I would have liked to. Well, I'll tell you  if  you
      want to hear this too. The car was brought to  Nepal  in  1932  before
      there were roads to  Katmandu  from  anywhere.  There  were  roads  in
      Katmandu; it's in an enclosed valley. The  car  was  made  in  Canada,
      shipped through India to the  Nepal-India  border  where  the  railway
      ended. It was put onto a bamboo platform, the car. The bamboo platform
      had handles at the end, pieces of bamboo sticking out.  I  can't  tell
      you how many, but 30 porters carried this bamboo platform with the car
      on top over the foothills of the Himalayas to Katmandu. If  you  don't
      believe me, there are pictures in National Geographic of the  30s  and
      40s showing porters carrying cars. There were lots of cars in Katmandu
      carried in that way including this one. Anyway that's an aside.

Dr. Sencer:      With that I think we'd better quit.

J. Friedman:     I think so.

Dr. Sencer:      Thank you very much, Jay.

J. Friedman:     You're welcome.

Maddie:     Thank you.


[End of audio 41:58:5]
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Mr. Billy G. Griggs, who was Deputy Director for
the Smallpox Eradication Program in West Africa. This interview is being
conducted on July 7, 2006, at the Centers for Disease Control and
Prevention as a part of the 40th anniversary reunion for the launching of
the program. The interviewer is Victoria Harden.

Harden:     Mr. Griggs, I would like to get a little background, to set the
           stage for your role in the smallpox program. I know you were
           born in Ripley, Tennessee, on November 20, 1933. Could you, just
           briefly, give me a little indication about your growing-up
           years, your pre-college education, who influenced you, how you
           grew up?
Griggs:     Well, Ripley is the county seat. Actually, I was born in
           Ashport, a port on the Mississippi River, 15 miles west of
           Ripley. And in 1933, this was boondocksville. In every way. Most
           of the things that came into Ashport came in by river boat. I
           went to school in Ripley-was bused 15 miles to school. I lived
           on a farm, of course. I had a rather uneventful, typical farm
           boy's life. I did all sorts of activities going on with farming.
           I went to high school at Ripley High School and graduated in
           1951.
                 I started to college my freshman year at Union University,
           which was a Baptist college in Jackson, Tennessee, about 45
           miles east of Ripley. I was influenced largely by the pastor at
           the church, which happened to be located on the farm. He kept
           pestering me to come to Union. So I went to Union freshman year
           and met a senior girl, who I was infatuated with. She finished
           that year and was teaching in Memphis, so I decided Memphis
           State was probably better than Union. We got married Christmas
           my sophomore year. I was self-supporting, and I worked my way
           through college, working all sorts of jobs and I graduated in 4
           ½ years. I came out of school with a house, 2 kids, a wife, and
           no debt, I might add, which is very good for college years.
Harden:     It certainly is.
Griggs:     I finished up the undergraduate work in January and decided to
           go on and do a master's in geography at Memphis State. I did the
           first semester but I was working, at that point, 48 hours a week
           at a soybean/cottonseed-oil mill at night. I decided that maybe
           I'd better slow down just a little bit. I knew there was a job
           opening down at the Shelby County Health Department for a VD
           [veneral diseases] investigator. On arrival down at the health
           department, I found out that not only was there the state job
           but there was also a federal co-op job vacancy. Tom Davis (from
           Atlanta) and Press Fish from the Nashville state office were
           there interviewing for the co-op job. The jobs were virtually
           the same, in terms of interviewing VD patients, locating their
           contacts, and referring them in for treatment for VD. The only
           difference in the state and federal jobs was that the federal
           job paid $500 a year more than the state job, and at the end of
           the year you were subject to transfer throughout the United
           States. This was a cooperative appointment between the State of
           Tennessee and the federal government. The feds paid the
           salaries, and you worked literally as a state employee on a
           local level there, at the City of Memphis.
                 Keep in mind that my motivation for coming down was going
           through school, working full-time, and making a living. And it
           was beginning to get a little tiring. I decided that I probably
           ought to slow down a little bit and finish this master's degree.
           So I applied for the federal job, thinking that I would just do
           a year at it, and I'll have my master's, and I'll get on with
           what I was planning on doing.
Harden:     Which was?
Griggs:     At that point I was still thinking possibly about law school.
           But some things had happened while I was working in a real
           estate company. I was manager of a rental department at one of
           the oldest and largest realty companies in Memphis and going to
           school at night. We had several young lawyers on retainer who
           were very smart, but they were having a tough time making a
           living. So I wasn't sure that I wanted to do another 4 years of
           law school after the master's.
                 So I applied, got the co-op job, and went to work. Two co-
           ops were hired, I might add. This was mid-June of '56. In early
           August, late July, Carl Hookings, who was the director of VD
           there, got a call that l of the co-ops was needed to go to the
           Mexican border to work with the Bracero Program. There was a
           pilot project being run to see if Braceros, who were Mexican
           agricultural workers, could be blood-tested for syphilis at the
           border. Then you could only have to follow up those scattered
           throughout the states when they went out from the border.
           Syphilis was the only blood test they were doing at that time.
           The Braceros were visually checked for syphilis and gonorrhea by
           a male nurse coming through.
                 I was married with 2 children. The other young co-op was
           married with no children, and he made a long pitch to Hookings
           why it really wasn't in his best interest to go to the border. I
           didn't have any strong feelings, and I thought the program was
           going to be over with by the time school started back. So I went
           out to El Paso. The 2 kids stayed with their grandparents. My
           wife went with me. She was going to stay 2 weeks and then fly
           back and take care of the kids. She was a teacher in Memphis.
           Well, we got to El Paso, and she decided that she didn't really
           like the idea because the program was going to take longer than
           we thought. So we made a hurried trip back to Tennessee, got the
           kids, rented an efficiency apartment, and started work.
                 And, believe me, in those days, things were a little
           different than working now-a-days. The Braceros came across the
           border at 6:00 in the morning, went out to the reception center,
           and we started work. They were processed through, and that meant
           a complete physical (in terms of looking at them, a chest x-ray,
           a blood test since we were there to do that), and then they were
           checked and recruited by the farmers, processed, and then went
           to the farm that afternoon.
                 The Braceros were all young, male agricultural workers,
           who were coming in for limited farm work. So our day started at
           6:00; usually we were through about midnight. The largest day of
           processing workers was 4,500 people who came through that kind
           of process all in one 24-hour period. We finished up in late
           September or October. And I returned to Memphis.
                 The good thing about the Bracero Program was that Bill
           Watson [William Watson], who was then the Program Management
           Officer of the VD program, and I became quite good friends. In
           the spring, I had taken the federal service entrance exam and
           made fairly high marks on it. I had gotten a lot of job offers
           from other agencies, at a considerably higher grade than the VD
           program co-op salary. Bill and I talked about this, and then
           Bill had a long conversation with Johannes Stuart, who was in
           Washington then, and then Stu and I had a long conversation. The
           sum total of it was, by the time I got back to Memphis, I was
           converted from being a coop appointment to a regular appointment
           career status as a GS-5, as opposed to the normal GS-7. I used
           to kid Bill that at that time he was the longest co-op that had
           ever been, and I was the shortest co-op. I was converted in
           about 5 months.
                 So I returned to Memphis. By the second year on the job, I
           was, as a GS-7, the federal city rep in Memphis for the VD
           program. I recruited all over west Tennessee and eastern
           Arkansas. I gave the people we brought into Memphis a rapid
           training program on how to draw blood. Then they went to the
           interviewing school in Atlanta, and then they were transferred
           throughout the United States. We hired some 50 people that
           second year in Memphis.
Harden:     How did you decide who was going to work out and who wasn't?
           Did you talk to each person?
Griggs:     I interviewed them all. I was the major interviewer at that
           point. There was not a central interviewing team; it developed
           later within VD for the large-scale interviewing. But we visited
           colleges, had an ad in the paper, and interviewed people. We
           tried to pick people who were resourceful, self-starting,
           understood kind of what they were getting into.
                 Then in the summer of the second year, because the pilot
           project had been very successful on the border, I went back to
           El Paso, which was the headquarters of the program. Five
           reception centers along the border, El Centro, AA, Nogales, AZ,
           El Paso, TX, Eagle Pass and Hidalgo, TX processed the Braceros
           who were initially screened at three centers in Mexico.  We had
           1 assignee in southern California, 1 assignee in Hidalgo, Texas,
           and me. I covered the Nogales, Arizona, and the El Paso station
           out of El Paso. That was my first real exposure to international
           work. We visited down in Mexico at the reception centers. Mexico
           had 3 such places, where the overall health of the workers was
           checked before they came to the border.
Harden:     And this experience is what made you the logical person, I
           suppose, to be coordinator for the International Symposium on
           Syphilis and Treponematoses in 1960-1961.
Griggs:     Right.
Harden:     This symposium was bringing together people from all over the
           world, then, or the Western Hemisphere?
Griggs:     It was worldwide. There were about 1,500 people at the
           symposium, held in Washington, D.C., at the Sheraton Park, from
           some 65 or 70 countries. It was a large meeting, probably a
           first-class meeting, with translation in French and Spanish.
           There were lots of papers, a lot of coordination in terms of
           getting the people together, letters out for the invited
           speakers, establishing everything that goes along with a meeting
           of that size. I had left El Paso and gone to Houston as the city
           rep. Then I went from Houston to Atlanta, when I was interviewed
           for this job as the coordinator of the symposium. I was offered
           the opportunity to live in Washington and commute to Atlanta.
           The VD program had moved from Washington to Atlanta in '57. Or I
           could live in Atlanta and spend a lot of time commuting to
           Washington and New York. The other sponsor of the program was
           the American Social Health Association in New York City. And
           with Atlanta being a much better place to live than Washington,
           that wasn't much of a problem. That was a supposedly temporary
           assignment for 22 months to hold that symposium.
                 At the end of that particular assignment, I went back into
           the VD program at headquarters as the Assistant Chief of
           Operations and Development. I had responsibility for the grant
           program, in terms of working with the states and the major
           cities in submitting and approving VD control grants. By now
           it's late '64. I got a call from Bill Watson 1 day, and he said,
           "There's going to be a program for smallpox and measles control,
           with USAID [US Agency for International Development] sponsorship
           and funding, that D.A. Henderson [Donald A. Henderson] is
           starting to get together, or and I'd like for you to go over and
           talk to D.A. about being the Program Management Officer and
           deputy of that program." So I went over and talked to D.A.
Harden:     And I understand that you had to do some selling about how to
           structure the personnel for this program.
Griggs:     D.A. had come out of the Epi program, and while he had had some
           exposure to Public Health Advisors, he had not really worked
           very closely with them at that time. I had to sell the idea of a
           joint effort with an M.D. epidemiologist and an Operations
           Officer. It clearly was going to be a program of operations, not
           just one of technical expertise.
Harden:     This is very important. Would you talk a little more and define
           what a Public Health Advisor did, how he was trained, and then
           explain if Operations Officers did the same thing or were
           slightly different?
Griggs:     The title "Operations Officer" was created for Africa, but they
           would actually have been civil service Public Health Advisors in
           the United States. The Operations Officer title was more
           descriptive for the African people than the title "Public Health
           Advisor" because we wanted it clearly understood that these guys
           were operationally involved. Just like in the Public Health
           Advisors in the United States, they worked with local health or
           state health departments or regional offices. But they pretty
           much had the understanding and expectation that they were
           responsible for getting the job done. Generally speaking, it was
           a situation in which, not that we can't do it, but how can we do
           it? In other words, if it needs something else, what do you need
           to get it done?
                 Public health advisors started out just interviewing and
           running down contacts, and then moved up to supervisory
           positions, grant writing. In some instances, they were literally
           functioning as VD control officers. So it was a multitask,
           multifaceted background and job. I might add that growing up on
           a farm didn't hurt any, either, because it was all of the kinds
           of things that you have to do in getting jobs done.
                 And if I may digress for one second, we had a problem out
           in El Paso, in terms of who was running the public health
           aspects of the bracero program. When we got there with 4 people,
           the quarantine people asked where the other 20 people were. But
           we couldn't slow down. We had to run these people through at
           that speed. So we had to work out a system that would let us,
           with 4 federal employees and a couple of local hires, handle
           that-drawing bloods and processing them; getting the results
           shipped to Austin and back again. So there was a lot of that
           kind of thing that came along. So I was used to multitasking and
           making do with what we had.
Harden:     So after you convinced Dr. Henderson to have Operations
           Officers in the smallpox program, what was the next step? Did
           you have to go out and hire people? How?
Griggs:     When I started with D.A., probably in November, there was an
           expectation that there was going to be a program, but there was
           a daunting list of things that had to be done before July 1966.
           When we started, no project agreements had been signed with any
           country in Africa, and there was no project proposal. We had to
           recruit personnel. We had to negotiate a PASA (Participating
           Agency Service Agreement), which would provide the funding for
           the program. We had to negotiate project agreements with Country-
           Specific Plans for each country in Africa. This would require an
           agreement between the US Government and each of the Ministers of
           Health of those countries to do the program. We had to develop a
           training program for the new employees to begin in July; it had
           to include language training as well as epidemiology and
           technical matters. We had to develop needs and specifications
           for all materials that would include quantity and quality and
           develop the Requests for Proposals (bids) for the equipment. We
           had to develop a comprehensive Manual of Operations, both
           technical and operational (which WHO latter took and issued it
           as though they had written it!). We had to develop the knowledge
           required to write individual country agreements that would be
           negotiated and signed by the host countries. All of this went on
           simultaneously. And we did it!
                 I think D.A. came around relatively quickly to
           understanding the need for the Operations Officers. He and Henry
           Gelfand, who was one of the other physicians in the office then,
           did a fair amount of interviewing physicians. Not only were we
           looking within the current EIS class, since we had the
           opportunity to get the young docs who came to CDC as an
           alternative to serving their draft time, but we were also
           looking outside of the Commission Corps. I might add that we got
           some very outstanding physicians that way. Don Hopkins [Donald
           R. Hopkins] was an individual who was hired as a physician from
           outside of the EIS, a direct hire. We also hired several more
           experienced physicians who went overseas. In most countries, the
           model was to have a physician epidemiologist and an Operations
           Officer. In a few of the smaller countries, the physician
           epidemiologist served 2 countries with an Operations Officer in
           each country. In Nigeria, because of its size and complexity, in
           addition to the headquarters office in Lagos we had multiple
           docs and OOs.
Harden:     My understanding is that there were an awful lot of details
           regarding the equipment that had to be used in the project. You
           had to deal with trucks, with doing procurements for trucks that
           were U.S.-made, getting them rigged up to have refrigerators for
           measles vaccine. Can you tell me about what all you had to do at
           this time from that standpoint?
Griggs:          Well, we had the benefit of a little bit of history of
           this. To backtrack 1 second . . .When measles vaccine was first
           in the process of development at NIH [National Institutes of
           Health], the Minister of Health from Upper Volta came over on a
           leadership grant visit. He was being shown the measles vaccine,
           and he said, "Measles is a major killer of children in my
           country, and I would like to offer my country as a place to
           field test the measles vaccine for you."
                 So in '63 or thereabouts, the USAID signed a project
           agreement with Upper Volta to go out and do several hundred
           thousand measles immunizations. CDC was asked to provide an EIS
           Officer to work with Hank Meyer of NIH as an advisor in the
           field for this team. USAID provided some trucks and the Ped-O-
           Jets (foot-operated hydraulic instruments that give an injection
           of the vaccine) to use the vaccine with; Merck, which had the
           measles vaccine, provided the unlicensed vaccine. And the
           program went to Upper Volta.
                 The first year, it was more successful than expected. I
           think they did about 700,000 vaccinations, and the next year the
           measles incidence in Upper Volta just dropped off to practically
           nothing. So the surrounding countries said that they would like
           to have a measles program, and USAID was negotiating to do that.
           They asked for 3 or 4 EIS Officers, and the program was expanded
           to 2 or 3 countries. The second year, they did not do the
           program in Upper Volta; they did the surrounding countries. The
           third year, Upper Volta got measles back-right back where it was
           to start with. So it was known early that in order to be
           successful in measles, it was going to require a fast-hitting,
           multiple repeat because the birth rate was so high that you
           built a new supply of susceptibles each year.
                 So the reason the smallpox program actually came into
           existence was that USAID come back to CDC and said, "We would
           like to have a major measles program, and we need 20 EIS
           Officers to be assignees to work with these countries on doing
           this." And D.A. picked up on this and said, "Measles is going to
           be a never-ending problem." So D.A. proposed the business of
           adding smallpox eradication to this measles program for West and
           Central Africa. The idea of pushing for a global smallpox
           eradication program had come up in WHO [the World Health
           Organization]. And this part of the world was probably going to
           be the toughest to try to do it in.
                 So it was proposed as a 19-country program, starting in
           Congo, and over to Chad, and Central African Republic, the whole
           West and Central Africa. That, USAID would consider doing.  We
           were putting together this proposal as to what it was going to
           cost for such a program-this was the project agreement proposal
           that I was talking about earlier. For that proposal, based on
           what information was available from the old measles program, we
           had to determine what kinds of vehicles were going to be
           required for each country, what kinds of vaccine, how much
           refrigeration space, the whole bit. This was all calculated into
           this project agreement for each individual country. It totaled
           up to a $46 million, 5-year eradication program for smallpox and
           control of measles in the 19 West and Central African countries.
           Subsequently, the other, 20th country was added, which was
           Fernando Po, which became Equatorial Guinea So we did our best
           guess as to needs on the basis of the life expectancy of the
           trucks, in terms of replacement on a 2-year basis; the life
           expectancy of the Ped-O-Jets; etc. All of this was listed by
           country. We started with 16 countries the first year. The second
           year we added 3 countries, Sierra Leone, Guinea, and Liberia.
           The third year, the 20th country was added.
Harden:     When you had to estimate the life expectancy and plan for the
           budget, were you correct? Did the items last that long, or
           longer, or not as long?
Griggs:     Well, we had some problems with vehicles that had not been
           expected. The Dodge truck was the vehicle that was chosen by
           bid. Bids were requested from Dodge, GMC, and Ford, and Dodge
           won the bid. And it was an eminently suitable vehicle. I was
           familiar with Dodge and was pleased that they won the bid. But
           we ran into the difficulties with the roads. This truck, being a
           long-bed crew-cab, had a lot of weight on the 2 axles, so a lot
           of axles were broken in Africa. And while we sent over with each
           truck each year a best guess as to what was going to be needed
           for repair, replacements to keep the vehicles running, it soon
           became apparent that we needed a system that would provide rapid
           turnaround in emergencies because if a vehicle was down,
           everything came to a stop. So we negotiated with an Atlanta
           Dodge dealer, a parts replacement general contractor, on a task
           order. We could just order what we needed, and it would be air-
           freighted to Africa. We would get a cable saying, "Gotta have
           this," and that day it was ordered and put on an air freight
           shipment. And it was usually in Africa in about a week, 10 days.
Harden:     And who actually did the replacement of the part? The
           Operations Officer?
Griggs:     Yes. But I'm getting ahead of myself a little bit. Going back
           to the spring, when we were writing these agreements, we
           actually had people start in late spring-Henry Gelfand, for
           example. And George Lythcott, who was a doctor working on a
           program in Ghana from NIH, was selected as the director for the
           regional office to be established in Lagos. Mike Lane [J.
           Michael Lane] and a couple other people were visiting the
           countries, negotiating project agreements, explaining the
           program, moving towards getting signatures.
                 After the participating agency service agreement had been
           signed with USAID and it was a pretty sure bet that we were
           going forward with this, we started recruiting people and
           started security clearances on doctors and Operations Officers.
           They were to report to Atlanta the first of July to go through
           the EIS course, which was normal training for that period. And
           then these recruits were to stay on for an additional training
           course in smallpox activities, in which there was a mechanic's
           course. It was lengthier for the Operations Officers, with a
           shorter version for the Medical Officers, to learn all about
           these Dodge vehicles and how to repair them. Now, keep in mind
           that the repair of the trucks was the responsibility of the host
           country. I mean, their facilities, their mechanics, supposedly.
           And they had had some exposure to Dodges, but not a lot.
                 But the Dodge turned out to be a very good vehicle. I was
           last in Africa shortly after retirement in 1989, in Togo, and I
           saw 2 of the Dodge trucks that had been there. The last one was
           probably sent to Africa in '70 or '71. And in '89, 2 of them
           that I saw out in the field were still running.
Harden:     Let's talk about going to Africa. Being the headquarters
           operation, you had to help all these people get settled in all
           these different countries. How did that work?
Griggs:     After the decision was made to have a regional office in Lagos,
           we were going to send 9 people there. We had a young, not brand-
           new EIS officer who was going to be the epidemiologist. George
           Lythcott was going to be the director. Jim Hicks [James W.
           Hicks], a senior Public Health Advisor, was going over as the
           administrative officer. Bill Despres [William Despres] was the
           assistant administrative officer. We also had a Muriel Roy, a US
           secretary, Gordon Robbins, as a health educator and Nat
           Rothstein [Nathaniel Rothstein] as a virologist. We were going
           to be there primarily to work with the vaccine production
           facility, to develop a creditable one there in Lagos to make
           smallpox vaccine. We also had a statistician, Davis [Hillard
           Davis] and Bill Shoemaker as an equipment specialist. So 9
           people were sent there. And they were to provide a nucleus of
           expertise. They could rapidly get from Lagos to the surrounding
           countries in those various areas statistics, senior
           epidemiologic skills, or an administrative function, or whatnot,
           rather than trying to have all that kind of expertise in each
           country or from CDC.
                 I first went to Africa in the summer of '66, with
           responsibility for working with the Department of State,
           embassy, and USAID, in terms of lining up office and housing
           space for the regional office people. We located offices,
           prevailed upon USAID to sign the contracts for the offices and
           houses. An activity out of Washington, called the regional
           office, had the responsibility for several of the smaller
           countries. So really all of the administrative sorts of
           activities were handled by the embassy, on agreement between
           USAID and the embassy and those countries. Providing office
           space was the responsibility of the host country, and they
           actually had an office in the Ministry of Health, or in an
           appropriate health building with the Ministry of Health. And the
           housing was provided by the US Embassy on a contract basis.
Harden:     And that worked out okay?
Griggs:     Worked out fine.
Harden:     In 1966, D.A. Henderson moved to Geneva, with WHO, and Don
           Millar [J. Donald Millar] came back from London to take over, is
           that correct?.
Griggs:     Don had been at the London School of Tropical Medicine, getting
           a degree, and he came home in the summer of '66. Don was missing
           during most of the preparation for the smallpox program. He got
           back just as we were getting folks to start.
Harden:     And I have a quote here that you said to him, "Welcome to the
           NFL." You want to explain that, and talk about how it was to
           shift from 1 leader to the other leader?
Griggs:     Well, Don and D.A. had a considerably different management
           philosophy, I guess you would say. I didn't know Don. I may have
           met him, but I had not remembered meeting Don until he showed up
           at the office coming back from England. We hit it off quite
           well. Don was completely unexposed to the operations office or
           the Public Health Advisors, but he quickly saw their value and
           was a champion of the Public Health Advisor throughout the
           remainder of his career, even after he became Director of NIOSH.
                 So after Don came in, the program was moving right along,
           in terms of the training activities; project agreement signings
           were slow. We had planned on sending the first people to Africa
           in September to get things kind of on the road at the end of the
           rainy season and be ready to start at the beginning of the dry
           season. The last pro-ag [USAID term for a project agreement] was
           signed, I think, in March of '67. There were considerable delays
           in getting all of these, and there was some very fancy footwork
           involved in getting pro-ags signed. It's too bad that George
           Lythcott's not here. George was a master at getting things done
           in Africa. I won't say how, but he wound up getting an
           appointment with the head of the government of Nigeria at the
           time after the coup. And he got a commitment that the pro-ag
           would be signed, and it was signed. That was the big one, with
           the regional office going into Nigeria and the 3 or 4 regional
           assignments within Nigeria. And because of its size and
           complexity, northern Nigeria had a Medical Officer and 2
           Operations Officers. It had a male and a female Operations
           Officer, the only female Operations Officer we had, because of
           the expected difficulty of working with purdah, in terms of
           getting the women vaccinated. And it worked out quite well.
Harden:     What was her name?
Griggs:     Vicky Jones [Clara Jones].
Harden:     Were there any unusual occurrences that you can think of that
           you can tell me about?
Griggs:     There were so many things that were happening. We had some
           problems with 1 individual, I recall, who had difficulty with a
           security clearance. He never got it cleared, so he was very
           unhappy. The people who were sitting in Atlanta with families,
           living in temporary quarters, and being delayed about going
           overseas, were considerably unhappy.
Harden:     And this was all coming back to your desk?
Griggs:     Mine and Don's. For the docs, it would go to Don, and Don would
           come to me. If it was the Operations Officer, he'd come to me,
           and then we'd try to get it resolved.
            Don and I went to Nigeria, for a meeting-it was after the
           program had started. The folks who were in Africa came to it,
           and they were less than happy campers, I guess is a good way to
           describe it. For a variety of reasons.
                 During the training session, because of the cross-cultural
           problems they were going to be facing, we tried to give some
           insight into the things, the do's and don'ts, or at least,
           "Think twice before you do it" type things. And I remember very
           vividly, one of the wives who had been aghast at the thought of
           having a cook, a nanny for the kids, a gardener, and a night-
           watch person, and maybe a small boy for the kitchen, depending
           on how many kids they had. This was the typical number of
           servants a family would have. She didn't want that.
                 But when she got to Africa, she was very unhappy because
           she was in an apartment. (We lived by the ground rules that the
           American embassy had, that folks with no children and single
           people were usually put in flats and apartments. If possible,
           families with children were given a house with a yard.) So when
           Don and I got to Yaounde, this woman was very unhappy because
           she was in an apartment when other folks had houses. So the
           uptightness about the ugly American with hiring the people and
           going to the market and sending the local hire to the market to
           buy food and whatnot, and not shopping for themselves, soon
           became a thing of the past. People realized that they just
           couldn't cope with that kind of activity.
Harden:     Very interesting. What was the toughest problem that you recall
           in this whole endeavor?
Griggs:     Oh. I hadn't even thought about that. I guess what caused the
           most consternation were the delays in getting project agreements
           and getting people out there, ready to go.
Harden:     So the beginning was [the hardest?] Once it was going, it was
           [ok]?
Griggs:     As you can imagine, people have a tendency, if a program says
           they're going to do 300,000 vaccinations, to want 400,000 doses
           of vaccine because they're going to have some loss at the end of
           the day. (Vaccine that is opened is discarded at the end of the
           day.) So they ordered more vaccine than they needed. Or some
           didn't order enough vaccine. It was a problem trying to second-
           guess people in the field, or respond back and forth to people
           in the field about what the realities of the program are. For
           example, you've got to have the vaccine, you have to discard it
           if it's at the end of the day, but if there are only 2 people
           left and you're going to be there in the morning, you don't
           necessarily open a large vial of vaccine to throw away-that type
           deal.
                 And the business of getting the parts. Having been in the
           field myself, I know it's never fast enough. "How come I didn't
           get it yesterday?" is the attitude.
                 So there was a certain amount of confusion and
           consternation constantly. But the program had a budgeted cost of
           $46 million. It was completed at a cost of just over US $30
           million-largely through some good work on the contract officer's
           part, being innovative and looking at alternative sources for
           things. So it was $16 million under cost, and it was completed
           in West and Central Africa a year ahead of schedule in terms of
           smallpox eradication.
Harden:     That is an amazing story. Tell me about the bureaucratic
           relations between headquarters in Atlanta and the regional
           office in Nigeria, in Lagos.
Griggs:     Sore point. The regional office was designed to start with as a
           resource of experts to be available for the countries. I wasn't
           involved in recruiting George Latchet, so I don't know what was
           said to him. George felt that the regional office was the
           director and that Atlanta was to provide support to the staff in
           the Regional Office. This misunderstanding was resolved, I think
           amicably, and George stayed through to the end of the program,
           and I think he was satisfied. He would have much preferred to
           have been running the program, but I don't know how to say much
           more about it than that.
                 Copies of memos and reports went to the regional office so
           that they were aware of what was going on, but things did not go
           through the regional office to be signed off on. Dave [David
           Sencer] just walked in, and I 'm sure that he may have a
           different story about this regional office conflict, but it was
           resolved. People were not ecstatic over the way it resolved, but
           the program operated.
Harden:     If you were going to undertake the program again, would you do
           anything differently?
Griggs:     Knowing what I know right now, I might do something
           differently. Not a lot. This doesn't sound right coming from me,
           but we didn't make a lot of mistakes in the smallpox program.
           Things were thought out, were worked out. We had a couple of
           people who I might not have recruited, but we didn't bring
           anybody home for improper action, or for not doing their job.
           And to have had 46 people in the field at 1 time-and overall,
           I've not even looked at the number, but probably with
           replacements, probably 60 or 70-people overseas-and not to have
           had somebody that didn't work out? We had a medical evac
           [evacuation] or 2, now. But I 'm talking about bringing somebody
           home for either being unable to carry out their work or the host
           country's saying, "Get this guy out of here"-that just didn't
           happen.
Harden:     That's also very impressive, is it not? Did you ever have any
           doubts that the program was going to be a success?
Griggs      :    No, none, after it got off the ground, in terms of
           smallpox eradication. Success in terms of measles control? An
           awful lot of people thought it couldn't be done. It was proven
           that it could be done with the right kind of input. Bob
           Helmholtz [Robert C. Helmholtz] ran the program in Gambia out of
           Senegal, and Tom Leonard [Thomas A. Leonard] doubled with Bob in
           Senegal for a short period of time. Tom was in Mauritania, when
           the '68 conflict occurred there, and the US Government left. Tom
           went and finished his tour in Senegal, but The Gambia had a good
           person who was in charge of the program, had a Minister of
           Health who was very much in favor of this. It was a small enough
           country, and while it was had poor roads, it had a river that
           ran through the middle of it, and you could get up and down the
           river. And The Gambia interrupted measles transmission and kept
           the country measles free for a couple of years. So it could be
           done. But it required an awful lot of effort, and I don't think
           Africa was ready for that effort. But smallpox was a success.
Harden:     How did you all, in headquarters, deal with the feedback you
           were getting, in terms of your conversations? The feedback from
           the people on the ground, and what you then said back to them?
Griggs:     There was a weekly newsletter that went out to all the field
           staff, which was kind of folksy. It originated in Atlanta. Don
           dictated material for it, and I added to it. It covered what was
           going on, what the problems were, what some solutions to
           problems were.
                 There were lots of phone conversations. In those days, you
           connected to French West Africa through Paris, and English West
           Africa through London, with a radio call from there on down. So
           you started out with a voice that they could hear at least 2
           floors above you, to build up impetus on the radio, and after a
           long conversation you almost lost your voice sometimes.
Harden:     What do you think that the Africans learned about CDC and about
           America from this program?
Griggs:     Some of them already had exposure to CDC. They had been CDC EIS
           officers in with the measles program a little bit earlier. The
           Operations Officers were told that their responsibility was to
           get the job done, but not to do it. If you do it, if you're out
           on vacation or out sick, things are going to go to hell in a
           hand basket quickly. So while it's much more difficult to train
           your counterpart to do the work, it's worth the effort if you
           want something left when you are not there. And you could very
           quickly see the difference when this philosophy was accepted and
           followed through on, as opposed to when work was done directly
           by the Operations Officer.
Harden:     So that was a legacy, then, that was left from the program?
Griggs:     That was a legacy that was left. To each of the training
           programs each year, we brought a cadre of docs and nurses. Now,
           Africa had a few docs, but most of the actual field activities
           of the program were carried out by nurses or kind of an African
           Operations Officer, if you want to call them that. A group of
           those came to Atlanta each summer-probably at least 100 people
           over the 5 years.
                 The last year of the smallpox program in Africa, when the
           CDC people were brought home, was '71. USAID wanted to follow up
           with a program for childhood immunizable diseases. Such a
           program subsequently came to CDC, through a participating agency
           service agreement. And the activities, the countries that were
           involved in this were virtually the same as those involved in
           the smallpox program, with some expansion into eastern and
           southern Africa.
                 So, all in all, I would think that from the standpoint of
           foreign relations-forget about the health aspects of it-the
           money spent on the smallpox program was probably better or equal
           to anything that was spent otherwise. In the 20 countries, there
           were a lot of coups and counter-coups, changes of government,
           and a civil war in Nigeria right in the middle of starting the
           program. And no one was evacuated except the team that was in
           eastern Nigeria. But in terms of a coup and a change of
           government, the smallpox and measles program proceeded as if
           nothing had happened.
Harden:     What impact did the program have on your career?
Griggs:     Hard to say. I guess it was probably good. Dave Sencer came in
           as the Director of CDC during the program, and I could have said
           this better if he wasn't in here, but I'm going to say it
           anyway. The smallpox program was accused of being Dave Sencer's
           pets, the fair-haired boys, but I might add that when Don and I,
           or subsequently after Don, when Bill Foege [William Foege] and I
           went to Dave and laid out what we needed, Dave bent over
           backwards and gave us what we needed, to the extent possible,
           and it was sufficient.
Harden:     Did this program have any impact on your family? Now, you were
           here in Atlanta primarily; you visited Africa but you weren't
           living there. But how did your family think about it?
Griggs:     I had a good wife, who understood being gone 3 weeks at a time.
           George Lythcott tried his damnedest to recruit me to go to
           Africa, to the regional office. And I turned him down. And
           obviously he had talked to D.A., and maybe to Dave, and I think
           they turned him down. Other than being away from home a short
           period of time, while I was in VD, I was home on weekends. But I
           traveled more days when I was working the 50 states than I did
           when I was working Africa.
Harden:     Did any of your children go into health-related work?
Griggs:     No.
Harden:     Not a one?
Griggs:     Not a one. As a matter of fact, my son may have had a negative
           impact from this. He was, I think, pleased with the work that I
           was doing, but he was adamant that he did not want to work for
           the government. I don't know who brainwashed him.
Harden:     Very interesting. Is there anything else you can think of about
           the program that we should capture in this interview, before we
           stop?
Griggs:     Well, I'm sure that Don Millar and others will say it better
           than I would, but the things that were really learned about
           doing immunization work from the smallpox program, in this
           country as well as other countries, have made a big impact on US
           activities, as well as on international activities in other
           countries. Obviously, D.A. was head of the smallpox program in
           Geneva. West and Central Africa cleared up right quickly. It was
           obvious that some problems were occurring in India, Bangladesh,
           and other places. CDC people from the West Africa program went
           overseas into many of those countries, to either get them kick-
           started or to stay there and wind up. In Bangladesh, India, Andy
           Agle was in Afghanistan, so it was a maturing of CDC's
           international venture, I think. While CDC is a domestic
           organization, when I left CDC we had people assigned in probably
           25 or 30 countries around the world, through WHO or through
           other avenues-the World Bank, UNICEF, etc. And this has
           contributed, in my estimation immeasurably, to other health
           activities. I think the Gates Foundation's work in international
           health goes back to the smallpox program. Bill Foege was a
           missionary in eastern Nigeria, and I guess was happy when we
           recruited him to be a contract doc for eastern Nigeria for us.
           And when he was evacuated, we brought him back here, and he
           became one of the lead people in smallpox. When Don left, Bill
           of course became the director. Went back to India for the wipe-
           up on that. I'm sure, no question in my mind, that the Bill
           Gates Foundation would not be doing what it's doing, if it were
           not for Bill Foege.
Harden:     Thank you so much for speaking with me.
###
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

Dr. Mary Guinan | with Interviewer Melissa McSwigan
Transcribed: January 28 2009 | Duration 0:54:36




Melissa McSwigan:      This is an interview  with  Mary  Guinan  on  July10,
           2008 at the  Centers  for  Disease  Control  and  Prevention  in
           Atlanta,  Georgia,  about  her  involvement  with  the  Smallpox
           Eradication Program. The interview is being conducted as part of
           our reunion, marking the 40th anniversary of the program in Asia
           and East Africa. The interviewer is Melissa McSwigan.

           Now, with this interview, we are hoping to  capture  for  future
           generations the memories  of  participants  and  their  families
           involved in eradicating smallpox from Asia and East Africa. This
           is an incredibly important and historic achievement and we  want
           to hear about your experience. I have some  questions  to  guide
           you, but please, feel free to recount  any  special  stories  or
           anecdotes that you remember about events or people. So you  sign
           the legal agreement which says that you were donating  the  oral
           history to the U.S. Federal Government and it  will  be  in  the
           public domain. You will have a chance to  edit  the  transcribed
           interview and add or delete information as you see fit before it
           is made public. So at this point, I'm going to ask you to  state
           your full  name  and  that  you  know  the  interview  is  being
           recorded.

Mary Guinan:     I'm  Mary  Guinan  and  I  know  this  interview  is  being
      recorded.

Melissa McSwigan:      Okay perfect. Could you maybe start  out  by  talking
           about how your education and upbringing led you into working  in
           Public Health?

Mary Guinan:     Well-I'm not sure how my education and  upbringing  brought
           me into Public Health, but I'll tell you how I  decided  that  I
           wanted to be part of the Smallpox  Eradication  Program.  I  was
           born in New York City, a child of immigrants.  My  parents  were
           immigrants from Ireland. They were farmers. They had maybe three
           years of education, 3rd Grade education level and they  came  to
           follow  the  American  dream.  There  were  lots  of   political
           persecutions in Ireland and they were - and  it  wasn't  a  good
           time. So they met on a ship coming here. Neither  of  them  knew
           anyone here in America and they established a  presence  in  New
           York. My dad worked with the Subway, the New  York  City  Subway
           System. My mom had a job as a dressmaker I think first, and then
           she was working in a house as an Assistant to  the  Chef,  in  a
           house in New York. Many Irish women came to  America  worked  as
           servants or assistants with large wealthy  families  and  that's
           what my mother did; and they eventually got married years  later
           - five years later. The Irish were very slow at this.

           I grew up in New York City and they believed in education.  They
           believed that that was the way to move ahead and they loved this
           country because of its freedom and lack of persecution for  your
           political views and they were very, very - they were very  loyal
           Americans and felt that this was really an important place to be
           and that we should be grateful-I was the middle of five children-
           we should be grateful for being born in  this  country  and  for
           exactly what we had available to us.  So  when  I  was  a  young
           teenager my dad died very suddenly and my mother had no means of
           support and we all got jobs to work our way through school;  and
           I worked my way through school and graduated from high school. I
           worked my way through college. I wanted to be a  physician,  but
           women weren't being admitted to medical school then;  and  also,
           one of the criteria for medical school was that you had to  have
           money to pay for it; and there weren't scholarships available or
           other things available to students like  me  who  really  didn't
           have the means to do that. So I decided then that I would pursue
           other things. I majored in  Chemistry  in  college  and  when  I
           graduated, I couldn't get a job because they didn't  hire  woman
           Chemists. So I was interested in - I got a job in a Chewing  Gum
           Factory...


Melissa McSwigan:      Really!

Mary Guinan:     ...making chewing gum. It was the American  Chicle  Company
           and they made Chiclets and all sorts of chewing gum. Black  Jack
           chewing gum was one of them and I was the Flavor Chemist. I  was
           hired as a Flavor Chemist so part  of  my  job  was  making  new
           flavors, developing new flavors  of  chewing  gum.  It  was  not
           terribly rewarding kind of existence, but  there  wasn't  really
           much available for women then and I try to look for  fellowships
           and I applied to many schools, to graduate  school,  and  I  was
           rejected mostly because I was a woman; and if I was accepted,  I
           couldn't get a fellowship program because they didn't give  them
           to women at that time. But at the time the Space Program was  in
           full bloom and with  Sputnik,  President  Kennedy  had  said  we
           wanted to be on the moon; that we were going to  the  moon;  and
           there were lots of became-available fellowships for  scientists.
           They wanted scientists to be  in  the  Space  Program  and  I've
           decided that I wanted to be an astronaut. So I  found  out  that
           the University of Texas was where the Space  Program  was,  near
           NASA in Texas, Clear Lake City,  but  the  University  of  Texas
           Medical Branch in Texas had a program for scientist in Aerospace
           Medicine and that the Director of  the  Medical  Program,  Chuck
           Berry - Dr. Chuck Berry, had an appointment at the University of
           Texas there. So I applied there to get my PhD in Physiology  and
           Space Medicine and I wanted to be  an  astronaut.  Of  course  I
           didn't tell anybody then  that  I  wanted  to  be  an  astronaut
           because women didn't do those sorts of things.

           So I went to Texas and people in New York said: You  won't  last
           there-about six months. You know you're a New York  person  born
           and brought up in New York. But I did, I lasted four years and I
           went to NASA. I applied - all of  my  class  in  physiology  and
           space medicine there at the  University  took  a  test  for  the
           Astronaut Program and I was the only woman who took it and I was
           the only one who passed the test. The reason I passed  the  test
           was I had 20/20 vision; and all the other people wore glasses. I
           mean that - and you also had to fit into  the  capsule.  It  was
           like the old days of being a flight attendant, you had to  be  a
           certain height and weight and not wear glasses. But I knew  that
           it was unlikely that I was going to be an astronaut, that  there
           was a great deal of competition for it. So I finished my - but I
           got to see all the astronauts,  I  took  classes  at  NASA.  The
           astronauts, you know like John Glenn  and  Neil  Armstrong  gave
           classes and talked about their  experiences  in  space.  It  was
           really exciting; I was really excited as a Scientist; and I  did
           a post doctoral fellowship; I got a Post Doctoral Fellowship  at
           the National Institutes of Health in Bethesda, Maryland; and  it
           was during the Vietnam War and I actually  had  gotten  a  place
           that was for a man who had been drafted. So I filled  in  and  I
           knew that I wouldn't really be  there  very  long  because  they
           saved the places for men who had been drafted and  had  gone  to
           war; and it was very difficult for  me  to  get  a  job  at  NIH
           because I didn't have an MD degree, and my mentor there  at  NIH
           said to me, "It would be so easy to get you a job if you had  an
           MD." You know, this is always the case, you know,  if  you  just
           did this, you know, we could get you a job.


           So I applied to two medical  schools.  Since  I  was  living  in
           Maryland, I applied to  the  University  of  Maryland  to  Johns
           Hopkins; and I got rejected from the University of Maryland  and
           accepted at Johns Hopkins which tells you  something  about  the
           crazy system we have about being accepted into medical school. I
           was very grateful because I was sort of an alternative  student.
           I didn't go from college to medical  school.  I  had  done  this
           detour and had been in Texas which most people  think:  What  in
           God's name did you go to Texas for? In Texas, people said, "What
           is this New York girl doing in Texas?" So I  think  one  of  the
           presumption was I try and find a rich husband, you know, a Texas
           oil man or something and that was the  assumption-there  weren't
           very many women doing graduate work. So I went to medical school
           and I graduated from Johns Hopkins in 1972 and during that  time
           period, I was continuing my  career,  I  had  done  my  PhD,  my
           doctorate in physiology in the area of blood coagulation  and  I
           was wanting  to  continue  my  career  and  be  a  hematologist,
           oncologist, and go in academic medicine. That's what I thought I
           would want to do. Never  thought  about  public  health,  didn't
           really know about public health. I went  to  medical  school  at
           Johns Hopkins where one of the premiere Public Health Schools in
           the nation is, and took courses but really had  no  interest  in
           public health at that time.


           But I was interested in tropical medicine and I did  a  tropical
           medicine fellowship in Mexico during my senior year  at  Hopkins
           and  was  interested  in  tropical  medicine.  Then,  as  I  was
           graduating, this was the end of the 60's and  beginning  of  the
           70's and what happened during my last  year  of  medical  school
           really changed my life, in that what  happened  was  Kent  State
           happened. People were killed for demonstrating. This is  a  free
           country, our Government. The United States Government,  which  I
           was very proud of being an American and  was  very,  very  upset
           about what happened in the anti-war demonstrations that went on;
           and then these students  in  Kent  State  were  killed,  unarmed
           students, by the National Guards that had been even called  out.
           People killed and I thought: What has  happed  to  this  country
           that I live in? How  can  this  be-that  we're  living  in  this
           country where they're killing unarmed demonstrators?  Our  whole
           history of our country was revolution and fighting  for  freedom
           and doing what we thought was right.


           So what happened was I decided I wasn't sure what I was going to
           do and so in my senior year I read in  this  magazine,  sort  of
           like a  magazine  at  Hopkins  about  the  Smallpox  Eradication
           Program. That there was this idea to eradicate smallpox  in  the
           world and I thought, "Isn't that wonderful? What  a  great  idea
           that we could eliminate a scourge. It would be the first time in
           history that by the design of man or woman,  there  would  be  a
           human disease eliminated from the world  and  smallpox,  a  very
           frightening disease." But you know, I just thought that,  "Isn't
           that a wonderful idea?" I didn't really  think  about  it  much.
           Then after that Kent State and I started doing my internship  in
           Internal Medicine with the idea that I  would  go  on  to  be  a
           hematologist and do a fellowship in hematology, oncology; and as
           I was going, during my senior of medical school, I  was  on  the
           clinical service with someone who was going to be an EIS Officer
           at the CDC. I had no idea what an EIS Officer was and he told me
           that it was the Epidemic Intelligence Service at  CDC.  I  said,
           "What's that?" He said it was a  two-year  program  and  you  go
           there and you learn how to be an epidemiologist, which I  really
           didn't have any interest in. Then I saw this  other  article  in
           the Hopkins Journal Magazine. You know, they  have  an  internal
           magazine, about this Smallpox Eradication Program worldwide, and
           how our Government was participating in it, our Government. So I
           thought, "Wouldn't that be wonderful to be part of a  Government
           Program that was really doing something wonderful?" Then I found
           out that the people who were going were being assigned from CDC,
           so you had to come to CDC and somehow get a job at CDC and  then
           you could be assigned to the Smallpox Eradication Program.


           So I talked to my friend at Hopkins about this  program  and  he
           said, "Yes, it's EIS Officers who were going over there  on  the
           Smallpox Eradication Program." So I applied to the  EIS  Program
           and in 1973 I guess, I was accepted; and I came to interview and
           I was the only woman physician in my class  that  was  accepted,
           and during that time, when you are hired at CDC you are hired in
           the commission core of the public health service  which  was  an
           alternative to military service and the draft was still ongoing.
           So people would say, "We're not accepting women here because  if
           we do, another guy has to go to Vietnam. So we're not  accepting
           women." During the interview I was told this when I came to  CDC
           for the interview. So I wasn't sure that I  would  be  accepted,
           but I was. I don't know why, but I was. I was accepted into  the
           program and so I came as an  EIS  Officer.  I  was  assigned  to
           hospital infections that's in  bacterial  diseases  then  and  I
           would go -  we  used  to  have  a  Tuesday  morning  seminar  in
           Auditorium-B every week for all the EIS Officers and we'd attend
           this meeting and there'd be announcements at the  beginning  and
           every time somebody from the smallpox program would  go  up  and
           say, "We are looking for volunteers for the Smallpox Eradication
           Program." You know it was a three or  four-month  assignment  in
           India now was the part; and I applied to go and  they  told  me,
           they were not taking women. Now, Indira  Gandhi  was  the  Prime
           Minister of India  so  it's  like  to  say,  "Well,  how  is  it
           possible?" That was the first round  and  then  each  week,  you
           know, they'd have somebody and finally, Phil Brachman  was  head
           of the EIS Program and I said, "You know,  I  keep  volunteering
           and I keep getting turned down, but I don't know  why.  Can  you
           tell me what the criteria are?" So I think they thought I  might
           make a fuss because I actually had made a little bit of  a  fuss
           although I didn't think it was a big deal,  but  everybody  else
           thought it was a big deal.


           When I applied to the EIS, I was accepted, but  we  had  to  get
           three references from physicians who knew us, and they  sent  me
           the reference sheets that had to be completed and it was:  "Will
           you please rate this  candidate  on  his  background  on  his  -
           whatever he does and is he a leader?  Is  he  going  to..."  You
           know, there wasn't a parenthesis with "she" and so I  sent  back
           the forms, I said, "I'm sorry. I'm a woman. Do  you  have  forms
           for women?" and apparently that caused some issues here  at  CDC
           before I arrived, so  they  figured,  "Oh,  oh-this  is  trouble
           coming." They wrote back and said, "We do not discriminate,  but
           we don't have any female forms." So, they crossed out  the  "he"
           and put "her" and "she" in the  appropriate  spots.  So  when  I
           came, I think that there was an idea that maybe -  feminism  was
           just sort of coming into existence. It really didn't exist until
           later; it was funny. So there was this worry I think so finally,
           they said, "You're going. You're going to India." So I  went  in
           December of '74 through early May of '75.

Melissa McSwigan:            Okay. So that was about  six  months  that  you
      were in India?

Mary Guinan:     Probably less-somewhere in there.

Melissa McSwigan:            And what was your exact role while you were  in
      India?

Mary Guinan:     What our roles were was that we  would  be  assigned  to  a
           district, some district area that - and you did surveillance for
           smallpox, looked for smallpox cases and then if you  found  one,
           you quarantine the case and then surrounded it with  a  ring  of
           immunity in a five or 10-mile  radius  around  because  smallpox
           spread locally;  and  this  have  been  demonstrated  in  India,
           actually Bill Foege who really was a person who worked this  out
           and really is probably one of the  people  responsible  for  the
           eradication of  smallpox.  Because  he  was  in  Africa  and  he
           probably told the story and you've heard it, but they would have
           a shortage of vaccine and they tried to figure out how to use it
           appropriately and they theorized that smallpox  spread  locally.
           So what you need to do  is  to  surround  the  populate  of  the
           infected person with a ring of immunity and then it won't spread
           because it only  spreads  from  person  to  person.  There's  no
           environmental reservoir  for  smallpox.  Humans  were  the  only
           source of smallpox; so you would find that  -  that  was  funny.
           Anyway that's what we had to do and we would be assigned. When I
           arrived at my destination, we first went to Geneva. On our first
           assignment, we'd go to Geneva and we met all the people who were
           being assigned; and I went with Walter Einstein from CDC who you
           probably will be interviewing too. He and I were both  from  New
           York City and we were assigned together to  Uttar  Pradesh;  and
           then we were assigned to go to Uttar Pradesh.

           So we were in Geneva and then we were sent to Uttar Pradesh  and
           there were still smallpox  in  Uttar  Pradesh.  There  were  two
           provinces in India, Uttar  Pradesh  and  Bihar  that  still  had
           smallpox. So it was like a competition between Bihar  and  Uttar
           Pradesh; who would come first down to smallpox zero?  What  we'd
           do is, we would go out into  the  field;  we  would  go  and  do
           surveillance. You were  assigned  a  driver  and  a  paramedical
           assistant and then you were given all  these  traveler's  checks
           like in Rupees because you had to hire people, and  you  had  to
           pay them. Then I would go to the bank and cash these  checks  so
           I'd have lots of money to pay people to immunize. You had to get
           vaccinators. You had to get people to work  for  you.  I  didn't
           realize what the whole system was in India, but since my  driver
           and paramedical assistant had been working, and  my  paramedical
           assistant was Shaffy[0:22:56] Mohamed, he was a Muslim,  and  my
           driver was a Hindu, and they spoke different languages actually.
           Shaffy spoke English perfectly, but his native language is  Urdu
           not Hindi, so that we had this three way thing going  on  trying
           to communicate with Urdu, Hindi and English. I didn't speak  any
           of either, but I learned to read the Hindi symbols  so  I  could
           read the road signs and they were very small - rarely was  there
           a road sign, but if there were, the driver couldn't read,  so  I
           would phonetically sound the symbols so I could tell  which  way
           the direction was pointing.  I  would  say,  "Kahnpour[inaudible
           23:44]; that way, okay  this  is  where  we  want  to  go."  The
           paramedical assistant acted as your interpreter, your  cook.  To
           find a place to stay, we were  issued  Tenson[0:24:10]  sleeping
           bags and these mattresses. You know,  thinking  about  India,  I
           thought it would be very hot and didn't bring any warm  clothes,
           but Uttar Pradesh is up North near Nepal and it got  very  cold.
           It was three degrees (3º) centigrade when I arrived at the Delhi
           airport and it was cold. So I had made a quilt, so I would  wrap
           it around me because I didn't have any warm clothes. We would go
           out and we would offer a reward; we'd go like to a  village  and
           the paramedical assistant would get up and say to the villagers,
           they had never seen a foreigner before so I was a  great  source
           of interest to people like: look at  me,  this  is  incredible..
           This is an area of Uttar Pradesh which was 99% illiterate.  They
           had never seen a foreigner before nor heard of America; and very
           often if we went to a Muslim village the women wanted me to come
           into their house because they didn't come out; they lived  in  -
           it was a part of their practice.


           So they always wanted me to come in to their house, their little
           mud hut, but they wouldn't allow  my  paramedical  assistant  in
           because he was a man, so I would go in there  and  we  would  do
           sign language. They couldn't understand; you know: Where were my
           babies? What was I doing there?  I soon found  out  everybody  -
           most of the women were pregnant, they had babies every year  and
           while I was there, there were several  babies  that  were  named
           America because they heard this word America. They had no  idea,
           they didn't have a concept of another language or another place;
           and if they asked my paramedical assistant  where  I  was  from,
           he'd say, "Oh, she's from the capital, Lucknow" Because they had
           no concept of another country and languages  but  they  couldn't
           understand why I  couldn't  understand  them.  So  it  was  that
           interesting. We would go to the village and we had these picture
           postcards that showed cases of smallpox and we would  say,  "Ten
           Rupees to anyone who can show me a case of smallpox" and it  was
           increasingly - 10 Rupees was a lot of money then for the average
           person. So if there was smallpox in the village they would bring
           you to the person. Very often it was chickenpox,  not  smallpox;
           or something else. It wasn't smallpox; and you were supposed  to
           be the expert, not having ever seen a case of smallpox,  it  was
           like strange to think that you were going to be the  expert  and
           tell whether this was smallpox or chickenpox. Of course we  were
           taught at all of these training sessions how to  do  it.  So  we
           heard about a report of smallpox in a village that was  supposed
           to be free of smallpox. So I was sent there out of my  district,
           my district was Kanpur, but this was outside of my  district,  a
           place called Rampur Madras. So I went there and I looked at  the
           case and it sure looked like smallpox to me; and at that time we
           took a culture of the lesions and put them in a little vial  and
           a mailing case. Then I mailed it off to  Delhi  and  they  would
           either confirm, because they wanted to culture every case to see
           if it was really a case; but  it  would  take  weeks  and  weeks
           before the results came back. I declared it as smallpox  and  so
           we started our immunization. There were vaccinators who actually
           worked in all the villages. There's this infrastructure in India
           where they have these people who are vaccinators; and they could
           be hired. So my paramedical assistant would  just  let  out  the
           word and people would come and want to work for you  because  we
           paid very well. So what we would do, we would pay  the  people's
           family to be guards at the door. This is  a  mud  hut  in  these
           villages and then we would pay a family member to be  the  guard
           at the door and the only people - they'd have to vaccinate them.
           Anybody who went in or out of the house had to be vaccinated.

Melissa McSwigan:            So this is the door  of  the  house  where  the
      smallpox patient was?

Mary Guinan:     Yes, the smallpox case. So here's  the  case:  this  was  a
           young man and nobody knew where he'd gotten smallpox from and he
           was a Brahman. The Caste System was a part of what was happening
           in India at the time although it was banned, it was outlawed, it
           was pretty much the practice. Everybody recognized  -  when  you
           went into a village the first thing people asked was what  Caste
           you were; and since I was an outsider, they weren't  quite  sure
           how to treat me, and so the Brahman didn't want me to touch him.
           You see this young man, they are Brahmans; but I interviewed him
           to try to find out where he got smallpox because he had to  have
           gotten it from another person, and where he had traveled; and it
           turned out that he had travelled to a village somewhere, I'm not
           sure where; where he had received the services of  a  prostitute
           for his inauguration into his, you know, Right of  Passage,  but
           of course, this was not something that anybody could know about.

Melissa McSwigan:            Right.

Mary Guinan:     And it was not something that I would  be  able  to  track.
           You know, to find out that case. In fact, they were  very  vague
           about where the village was and how it was. So we  just  decided
           then to employ a member of the family, it was a father, to be at
           the door and  then  we  paid  a  vaccinator  to  stay  there  to
           vaccinate. We paid the parents money to keep the person  in  the
           house-keep the young boy in the house and  to  get  food  so  he
           wouldn't come out until we declared him to be non-infectious. So
           we went about, and I found out that when we go to  the  villages
           surrounding it, we didn't have maps, it wasn't like  you'd  say,
           "Okay let's draw a five-mile radius around this and try and find
           some maps to figure out what the radius was or how you could  do
           this." So, we got these rather rudimentary maps and  we  started
           going to the villages to try to vaccinate.  We  found  out  when
           people would come - we had a jeep, they were Mahindra &amp;amp; Mahindra
           jeeps I think is the name of them, and they were provided by the
           Indian Government, the jeeps; and when the jeeps  came  and  the
           only time the villagers ever saw a jeep come  in  was  when  the
           Family Planning person came and there was a  big  initiative  in
           India at that time to reduce the  population  and  to  introduce
           birth control, and they used to pay the men to have a vasectomy,
           gave them a portable radio was one of the  gifts  that  the  men
           would get.

Melissa McSwigan:      Mmh!

Mary Guinan:     And then were these - the Family Planning people  had  told
           us that they had to meet every month. They had to have  so  many
           vasectomies and so  many  tubal  ligations  and  they  were  not
           terribly receptive people so they saw this jeep coming and  they
           thought it was the Family Planning people and they all ran away.
           So nobody would be there. So we said, "We couldn't find  anybody
           to vaccinate, everybody disappeared." In India, you know, people
           would disappear and then reappear;  it  was  so  incredible  the
           number of people; when you go to India, all you  see  is  people
           everywhere. There's never any privacy. You  go  out,  you're  on
           this road and you're there in this  wheat  growing  and  things,
           this farm area and you go, and if  something  happened,  if  you
           broke down, my driver would just shout out, and all of a  sudden
           people would appear and they'd come out  of  the  fields,  there
           were people everywhere. They'd sleep in the  fields,  they  were
           there, but you know, with the  heat  they'd  be  hiding  in  the
           shade.

           So the whole idea of us  being  Family  Planning  people  caused
           problems for us to be able to do the immunization.  So  what  we
           decided to do was to do a survey of the town,  to  get  all  the
           names, and this was something that we understood what the people
           used to do that gave - what the politicians used to do  to  give
           resources to a town or village. They would take a census of  the
           village, and the village then - and  then  take  the  census  of
           everybody who lived in each house in the village and maybe there
           were 50 or 60 or 70 houses in the village  or  less,  and  there
           usually would be sometimes 10 or 15 people living  in  that  one
           room mud hut. So we would just go  in  and  say  we're  doing  a
           census; and we'd go to the village Elder and  talk  to  him  and
           tell him first that we were going to do the census; and then  we
           would tell him after we did the census when we had all of the  -
           then we would ask the Elder if we could  vaccinate  the  village
           and why. If the elder agreed then, we could  go  and  start  the
           vaccination.


           So we would go, but we knew how many  people  were  there.  They
           would all sort of list all these children and  you  always  knew
           that there was a child every year, so if you had a  one-year-old
           that look like one,  you  would  look  for  the  baby  somewhere
           underneath, hidden in blanket somewhere there was always a baby.
           So we would find a baby. It was just amazing, we would  ask  how
           old people were and they didn't know how  old  they  were.  That
           wasn't a concept to them, the children how old they were. So  we
           would just guess at their ages, and then we would vaccinate them
           and vaccinate each village until we completed the circuit.  Then
           I'd come back every once in a while to make sure that the  guard
           was at the door.  We  had  these  surprise  inspections  because
           people  didn't  really  understand  what  we  were  doing.  They
           thought, you know: Okay, they're going  to  give  me  money  for
           this, I'll do it, but then when I was out of sight,  well  maybe
           not understanding why they needed to keep  this  person  inside,
           they might not, you know - So we would come  back  regularly  to
           check every two or three days. Sometimes there wouldn't  be  the
           guard at the door and we say, "Okay, where is the guard?" and we
           had the guard and the vaccinator had a book in which  he  listed
           all the people he vaccinated so we'd know who  were  vaccinated.
           So that was my first start, and it was smallpox and then I  kept
           finding more smallpox cases.


Melissa McSwigan:            So that was your first  case,  but  there  were
      more?

Mary Guinan:     That was my first case, and then as we  went  from  village
           to village, I'd find another one and declare it  then,  I  would
           culture the lesion and send it off to the post office  and  this
           is a big thing to do, to find a post office that would take this
           and send it off to Delhi. You'd never know if  it  would  arrive
           there or not, because sometimes they didn't have stamps  at  the
           post office so you couldn't buy stamps and it was a  complicated
           system that you had to try and figure out  how  to  ensure  that
           your specimen got sent. So I kept sending them off and  then  we
           kept moving around from village to village; and the  person  who
           was in-charge of Uttar Pradesh  at  the  time  of  the  Smallpox
           Eradication Program was Don Francis and he would come to  visit.
           He came down to visit me about a month and two into it. I  lived
           in a mud hut outside and my paramedical assistant would try  and
           find some place for me to live, that would have a  shelter;  and
           sometimes we did and sometimes we didn't. It was  very  cold  at
           night. But there were all  sorts  of  things;  there  were  rats
           around that really used to scare me.  They'd  come  in  and  run
           around at night and the Indians always respected life.  So  they
           never killed anything. The Hindus didn't kill  anything  and  so
           there would be rats.

           One morning, there was a rat in my purse and I  told  my  driver
           there was a rat in my purse and he just opened the purse and let
           the rat out. Okay! So Don Francis came down to visit to see what
           we were doing because they wanted to make sure, you know  I  was
           new, of what you were really doing and actually, I was  a  woman
           and they weren't sure women could do those things at that  time.
           So Don came down and he said, "Listen, this place  was  declared
           free of smallpox and you are sending off all these sample saying
           there's smallpox. Are you sure these are smallpox?" I said,  "As
           sure as I can be. I certainly - all I can say is, to the best of
           my  ability  I  call  them   smallpox."   "Sure   they   weren't
           chickenpox?" "I think they were  smallpox,  it's  a  possibility
           that they were." He said, "Are you sure because you're causing a
           big sensation here. The leader, the Indian Public Health  leader
           in the area was very upset because he had declared his districts
           free of smallpox and I was saying it wasn't. So  that  caused  a
           little political problem. Anyway, it was miles and it would take
           them several hours to come to where I was, and they  went  back.
           Then as I moved toward the other villages that were infected  in
           this area, we had difficulty crossing  the  rivers.  There  were
           three rivers - parts of a river that  intersected  the  villages
           and each time I would have to cross the river; and  it  was  too
           deep for the jeep to cross it, so I decided  the  first  day  we
           came to this I said, "I'm going to  wigan[inaudible0:41:35]  and
           wade across" because the water was the water is about up to here
           maybe at my waist, and we're  going  to  wade  across  with  the
           supplies and everybody would wade across. So I always wore pants
           because showing your legs is not something that the Hindu  women
           or Muslim women do, so I had made a  series  of  Muslim  outfits
           like pants and a long shirt, a Kurta, I think it was called  and
           that's what Muslim women wore. The Hindu women wore  Saris,  but
           the pants were much easier for me to work in and I  always  kept
           my head covered. I had very long hair then, it was a braid and I
           decided before I went to India that I would dye my hair black so
           I wouldn't look so conspicuous.

Melissa McSwigan:            Did that work?

Mary Guinan:     No. Well, you know, when the  white  roots  started  coming
           out, they thought I was going grey; and it got  streaked  as  it
           went, and I'm pretty tall; so I was taller than what most people
           saw, so I stuck out in the crowd no matter what. So I decided to
           roll up my pants-now I tell you that showing legs isn't  a  good
           thing in India, and there was nobody around, but after I  rolled
           up my pants and started going across the river, a big crowd came
           out and there was a huge crowd, and I had rolled up my pants and
           I'd walked and crossed to the other side  to  get  the  supplies
           over, the vaccine, needles and things. Then we went and did  the
           thing and on return I realized that I'd caused some sensation so
           I just didn't roll my pants up, I just  waded  across  and  word
           travelled fast, who knows how, but it went to Delhi; and  people
           were saying, "Oh, I heard you went to..."

           Once a month we would have this meeting and Bill Foege  would  -
           Bill Foege was the head of the Indian  Smallpox  Eradication  at
           the time when I arrived, and he would come  up  from  Delhi.  He
           would go to each of the districts once a  month,  and  he  would
           come to Uttar Pradesh one day a week and then we would all  come
           in from the field, there were number of us; and he was the first
           person that we would talk with, and we'd take showers, I mean  I
           might not have showered in weeks and weeks. So you would stay at
           the hotel and meet friends, and they would  tell  you  what  was
           happening, and they'd show you how many cases of smallpox  there
           were and how they were decreasing and how close we were to zero-
           coming to zero in India; and that UP was winning from Bihar.  We
           were ahead of Bihar. So that was a monthly meeting  and  when  I
           was coming into town, we would stop at the railroad station  and
           I would know whether Bill Foege was there or  not  because  Bill
           was very tall, he's 6'6", and they would  always  know  when  he
           came from the railroad station. He was here. So they'd tell  me,
           "He's here." So I would know he was at the hotel.  People  would
           know you were with the smallpox program and they'd let to  know,
           I mean, word would travel fast and anything I did was  reported.
           People knew what I was doing and all. That  was  interesting,  I
           didn't do that again.

Melissa McSwigan:      How would you - let me interrupt you  for  a  second.
           How would you say that this experience that  you  had,  the  six
           months that you had in India, how would you  say  that  affected
           your career after that?

Mary Guinan:     Well, I became a believer. I believed  that  this  was  the
           way to go. I decided that I was going to have a career in public
           health because it was so successful. I mean, I couldn't  believe
           it, what you were doing and all the things you  were  doing  and
           all the problems you were having, and you would come,  and  it's
           working. It's actually working, so you were reinvigorated to  go
           out in the field and keep doing what you were doing because  you
           can't really see the results and you often see the  errors  that
           are made  and  sometimes  things  slipped  through  the  cracks,
           somebody didn't guard the patient, and did they possibly  infect
           someone else and you had a whole trail of smallpox moving about.
           You're always worried about that, but it worked. So I decided to
           work in public health-that changed my life.

Melissa McSwigan:      Did you keep travelling after that?  Did  you  go  to
           other countries as well?

Mary Guinan:     Yes, I've been probably all over the world.  I've  been  to
           Asia: Thailand and China, Japan; and Central and South  America.
           I guess the only place I  really  haven't  been  is  to  Eastern
           Europe. So it was the - during that time it was the Cold War  so
           there were lots of difficulties getting in and out of countries.
           But I came back and then I left CDC after  my  EIS  program  and
           then was recruited back to CDC, and then I worked at CDC for  20
           years then retired. I was part of the First Aid Task Force so  I
           was a trained Virologist and that's how my career evolved.

Melissa McSwigan:      It sounds like you faced a lot of  challenges  before
           you went for the Smallpox  Eradication  Campaign.  Particularly,
           you've talked a lot about being a woman and how  that  presented
           some obstacles as far as getting into school and so on. Did  you
           find that  in  this  particular  campaign  that  being  a  woman
           affected the work that you were doing? You talked a  little  bit
           about when Don Francis, I think you said, came to visit you, how
           they kind of doubted maybe your effectiveness?

Mary Guinan:     Well, they were worried. You know, as I  would've  been  in
           Don's place. It turned out they were all smallpox. But  I  think
           it did affect the people - I think it helped me  a  lot.  People
           were much more trusting of a woman than a man in that  situation
           when I'd go into a village.

Melissa McSwigan:            That was as far as the Indians were  concerned?



Mary Guinan:     Yeah, as far as the Indians were concerned. Because  I  was
           such a curiosity to them; and also, people helped me  a  lot.  I
           told you about these rivers.  We  had  problems  traversing  the
           rivers and the only way to get across was a boat, a camel or  an
           elephant. So there were always camel drivers and we  would  just
           wait until a camel came along then I would rent  the  camel  and
           then we'd get across; and how I got back  from  over  the  other
           side; we'd hope another camel would come or somebody would  show
           up with a rowboat and would row us across. We'd pay them to take
           us across. So one day, while we're working in the village,  this
           local Raja Saab they call him came, and he said, "What  are  you
           doing?" And I told him what we were doing and he  said,  "That's
           wonderful." He said, "Well, since you're having this difficulty,
           I have an elephant and I'm going to give you an elephant so  you
           can have this elephant to go across the river." So  I  got  this
           elephant. I mean elephants swim and their wonderful. Camels  are
           nasty and they want to bite you. It's really  difficult  getting
           on a camel. They'd turn around and bite you; and  the  elephant,
           very sweet and there was a Mahout, an elephant  driver,  and  he
           said to me, "When the elephant swims over this  river,  he  will
           take you up in his trunk, so you won't get wet" I said, "No. No.
           I'm not doing that. I'll get wet-it's okay if  I  get  wet."  So
           when we would go across, he would take the Mahout. The  elephant
           would take - it was a female, she would take the Mahout  in  her
           trunk and carry him over, and swim to the other  side  and  then
           I'd go; and then we'd come back and then somehow somebody  would
           call an elephant. The elephant would come and then take me  back
           to the other side.  Of  courts  Don  Francis  heard  about  this
           naturally, and he came saying he wants an elephant ride. He came
           down, he says, "I want my first ride." So  he  got  an  elephant
           ride. So I'm not sure, I think this man, because I was a  woman,
           he thought I needed help in getting across and so, he gave me an
           elephant. I gave it back to him. I didn't take it home.

Melissa McSwigan:      That would be kind of hard to fit and  you're  carry-
           on luggage I'm sure. What would you say is  the  most  memorable
           moment that you have from your time in India with  the  smallpox
           program, the memory that sticks out the most?

Mary Guinan:     Well the memory is - and the first is  the  cultural  shock
           of going to a country  where  you  don't  know  the  morays  and
           learning them it's a bit of a  - it was  one  of  those  culture
           shocks that it would take years to  adapt  to,  you  take  these
           small steps. But I think that the most exciting thing  was  that
           it worked and that these monthly meetings that we would  go  to,
           we would learn that it was working. It was just - and that whole
           idea that this is actually going to work. I mean, it's  actually
           going to work was intoxicating. So that was the  most  wonderful
           thing about - and the thing I remember, it was effective.

Melissa McSwigan:      Well, is there anything else that you would  like  to
           add, to tell future  public  health  professionals  like  myself
           about the time and the program and so on that you would like  to
           share?

Mary Guinan:     I don't think so. I don't know  what  I'd  say  except,  an
           opportunity like this where your Government was doing  something
           and you have an opportunity for public service, it's  just  -  I
           don't know that I got any better satisfaction of  anything  I've
           done in my lifetime, than feeling like I  participated  with  so
           many other people  from  other  nations  to  do  something  that
           improved people's lives and you had an opportunity,  I  mean  it
           was a privilege to have that opportunity, so  I  feel  that  our
           government who was doing what I thought, such  terrible  things,
           but somewhere there was someone doing this wonderful  thing.  It
           was in these rickety old buildings at CDC that nobody ever heard
           of  then,  CDC  wasn't  in  the   spotlight,   and   all   these
           Quonset[0:53:41] huts out in [inaudible  0:53:43],  that's  what
           people were living in. I mean this is CDC and it was  these  old
           Government buildings, but these people  planned;  imagine,  they
           planned as  well.  They  were  part  of  the  planning  of  this
           momentous event, and I feel very privileged to have been a  part
           of it. So it was that sense  of,  I  guess,  if  you  have  that
           opportunity to do something that's outside of anything you could
           possibly do as an individual, do  as  a  team,  then  that  will
           surely be one of the greatest satisfactions in your life.

Melissa McSwigan:      Well, thank you very much for  your  time  and  thank
           you for sharing your stories.

Mary Guinan:     Okay.


[End of audio - 0:54:36]
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

D.A. Henderson with Paul O'Grady
Transcribed: February 2009



Paul O'Grady:    This is an interview with D. A. Henderson on July 12,  2008
           at the Center for Disease Control  and  Prevention  in  Atlanta,
           Georgia about his  involvement  with  the  smallpox  eradication
           program. The interview is being conducted as a part of a reunion
           marking the 40th anniversary of the program  in  Asia  and  East
           Africa. The interviewer is Paul  O'Grady.  Can  you  state  your
           name?

D.A. Henderson:  D. A. Henderson

Paul O'Grady:     And  you  understand  that  this  oral  history  is  being
           recorded?

D.A. Henderson:  Yes, I do.

Paul O'Grady:    Thank you. I would like to start off by having you give  us
           a little bit about your background, what lead you to a career in
           public health and how you started working for the CDC?

D.A. Henderson:  Well, I was born and brought  up  in  Lakewood,  Ohio  near
           Cleveland. Went to Oberlin College and then to the University of
           Rochester School of  Medicine.  After  internship  at  the  Mary
           Imogene Bassett Hospital in Cooperstown,  I  was  told  that  my
           deferment from the draft was at an  end  and  I  had  my  choice
           either to voluntarily enlist in which case I would  be  a  first
           lieutenant, or be drafted in which case I would  be  a  private.
           So, like many of my colleagues who had been deferred  since,  in
           my case 1946, and this is 1955, I decided I could  volunteer.  I
           was having difficulty making up my mind  whether  it  was  army,
           navy or air force. I figured I am just an intern, all I am going
           to do are boring draft and do physical of new recruits. So about
           this  time  somebody  shows  up  from   something   called   the
           Communicable Disease Center, which I had never  heard  of.  They
           are from the public health service which I knew  nothing  about,
           but they talked about working on  infectious  diseases  which  I
           didn't really much care for. As I  thought  about  it,  well  it
           might be two years and I'd learn something, and as they  pointed
           out we don't wear uniforms, we don't salute, you don't do  basic
           training. I  go,  well,  okay,  doesn't  sound  too  bad.  So  I
           enlisted, in the public health service.

      Now, this was the Epidemic Intelligence Service  which  at  that  time
           was only four years old. That created by Alex  Langmere  at  the
           CDC. There were, however, quite a  number  of  applicants  every
           year who were anxious to do their required time and  service  at
           CDC  would  be  challenging,  interesting,   so   forth.   Well,
           fortunately I had done a history of medicine paper  in  my  last
           year of medical school. Why had a done the history  of  medicine
           paper? Because  they  offered  $200  and  a  handy  subject  was
           something about cholera in upstate New York in  1834  and  there
           was material available in the newspapers and so forth.

      So I spent time creating this paper,  going  through  the  newspapers,
           plotting cases, doing curves. I didn't know what I was doing  in
           terms of training but it really was epidemiology and in fact  it
           turned out to be rather fun. I had to see what the responses  of
           the health department were, to the  various  challenges.  Seeing
           how it spread through the city and so forth. So  in  advertently
           I'd become interested in a subject which we had no courses in at
           all and I got drafted to the public health service. That's where
           I got into public health and I had no interest in public  health
           either at that time. I was going to be in my mind a cardiologist
           and this would be two years  out  and  then  I  go  back  to  my
           residency in cardiology.

Paul O'Grady:    What were the major public health concerns at that time?

D.A. Henderson:  There was one dominant major public health problem at  that
           time or challenge and that was polio myelitis.  There  had  been
           significant cases, significant outbreaks of polio  myelitis.  In
           the 1950s, there was a great deal of fear  at  that  time  about
           polio. In the summers there was - they  closed  swimming  pools,
           parents kept their children away from other children.  If  there
           were outbreaks  there  was  a  great  deal  of  anxiety  in  the
           community. The National Foundation for Infantile Paralysis was a
           very major foundation. It was the only categorical foundation at
           all  that  time.  It  had  been  started  because  of  President
           Roosevelt's, Franklin D. Roosevelt's polio myelitis and they had
           raised for Warm Springs, Georgia rehabilitation center. They had
           been extremely successful and they took some of this  money  and
           they put it into some basic research of very  good  quality  and
           development of the vaccine. There was great anticipation in 1954
           because they began the first major study of the Salk vaccine and
           there was school children across the country. I forget how  many
           were involved. As I recall it's 100,000 plus.

      The results were coming up in April of that year that I was  doing  my
           internship. Very soon thereafter they  began  to,  in  April,  I
           guess they announced the  results  and  they  began  vaccination
           around the country with the vaccine. About this time they  found
           that some of the lots of vaccine were not quite - the virus  was
           not quite as dead as it should be. They began to  get  cases  of
           polio myelitis, paralytic disease caused by the  vaccine.  So  I
           was being inducted into the Center for Disease Control.

      The epidemic intelligence service Alex  Langmere's  group  were  doing
           the work of compiling information on the cases in trying to find
           out which lots of vaccine were involved and trying to  determine
           the magnitude of the problem and then what to do about it. So we
           were totally immersed, as I came into the service on the 1st  of
           July with what was an ongoing investigation into what really was
           the end of the largest field trial ever conducted on  a  vaccine
           and the introduction of the polio myelitis vaccine which  was  -
           had been awaited for so long. At the same time we had  what  was
           amounted to a vaccine incident which was serious with  a  number
           of paralytic cases associated with  the  vaccine.  The  question
           was, was it the vaccine of all companies or  was  it  maybe  one
           company and only some lots of the vaccine or  what  was  it.  So
           this was all absorbing for many of those who came aboard at that
           time.

Paul O'Grady:    And how many years were you at CDC after your - so you  got
           a two year government required service and then you stayed on?

D.A. Henderson:  Well it turned out be  rather  more  exciting  than  I  had
           thought. They had a matching program. So,  that  those  who  are
           recruited you then submitted  your  preferences  on  a  list  of
           different positions you could have. They in turn would  look  at
           the people who are coming in, about 30-35 of us and decide which
           ones they wanted and they would list their priorities  and  then
           they match them up. I matched  up  with  a  position  which  was
           called assistant chief  of  the  epidemic  intelligence  service
           which would be as they called it a go-for job  kind  of  putting
           things together, helping organize a course and doing  things  of
           this sort.

      Well, we would have a course to a one month at that  time  where  they
           taught us epidemiology and  bio  statistics.  Basically  how  to
           investigate an outbreak and at the end of the one month you  are
           then a qualified epidemiologist in our terms and at the  end  of
           that course I had to go off the  epidemic  intelligence  service
           did to an epidemic. We were constantly being called for  various
           epidemics. There was a big epidemic  of  diphtheria  in  Phoenix
           City, Alabama. I went down, I spent three weeks down  there  and
           giving vaccine, taking cultures. The patients were housed  in  a
           big Red Cross tent. I came back and here was the chief  epidemic
           intelligence service officer packing his bags.  I  said,  "Where
           are you going?" He said, "I have another job. I am going to be a
           state health commissioner." I said, "Well, what  do  I  do?"  He
           said, "I guess you are the Chief EIS officer." I said,  "I  have
           no idea what to do?" He said, "You will learn."

      Sure enough, then I began working in a job that certainly  I  was  not
           qualified for but plunged in. With the mentorship of  this  Alex
           Langmere who was a legendary epidemiologist, a rather  difficult
           person but demanding and  just  a  wonderful  teacher,  just  an
           extraordinary teacher. At the  end  of  two  years  of  this,  I
           finished my duty. I proposed  to  him,  you  know,  we  are  not
           keeping many people on. The people were getting, so many  people
           apply. They are  well  qualified.  All  of  them  wanted  to  do
           academic medicine or pediatrics. Just about nobody wants  public
           health.

      Now, if we offered a 5-year training  program  in  which  you  do  two
           years of training, like a residency in  cardiology  that  I  was
           thinking for myself, and maybe then three years with the  public
           health service. Maybe that would be a  way  to  attract  people,
           then by then you will have, say then, seven years and  we  might
           get people staying longer. Well, he  liked  the  idea  and  then
           well, he submitted it up-line to the surgeon general.  He  liked
           the idea. So, I applied for a five  year  training  program  and
           went back to get my residency.

      At the end of the - well, during the course of the residency, I  found
           this to be frankly rather boring. I was seeing patients and some
           of them had some heart  disease  and  heart  failure,  a  little
           diabetes, a little gastroenteritis. A  little  constipation  and
           sort of the end of the day I felt, you know, if I really  hadn't
           been there, I wonder if it would have made  any  difference  and
           was I making any difference. Am I going to be doing this for  my
           next 40 years?

      Well, meanwhile I had been two  years  in  the  epidemic  intelligence
           service which some exciting outbreaks here and  there  including
           one which was an interesting one in Argentina. There was  a  big
           outbreak  of  food  borne  disease.  They   were   stoning   the
           restaurant, the Argentine government was upset. They thought  it
           was a type of food poisoning due to the  Botulinum  toxin.  They
           wanted our, what we had in the way of antitoxin to  treat  them.
           So I took off for Argentina with such supplies as we had.

Paul O'Grady:    When was this?

D.A. Henderson:  That was 1957. At the end of this I saw  the  secretary  of
           health. He sort of offered "Well, let's go on a hunting trip  or
           a shooting trip with me at my lodge." I said, "You know, I  hear
           you have got an outbreak of smallpox." He said, "Yes."  I  said,
           "I would like to go see it." So he said, "Fine." We took off  on
           an old Pan-Am clipper off the waters and the river on La  Plata.
           On up to another place and we got in a two passenger  piper  cub
           and flew into a smallpox - the area where they had the  smallpox
           and they had an outbreak of smallpox. The people were  in  tents
           in the field and so, about 30 different patients. We  looked  at
           the patients one by one, it was fascinating. And at that  point,
           I had never seen a case of smallpox, really didn't know what  it
           looked like. But it was my first contact with smallpox.

Paul O'Grady:    Was there at  that  point  any  national  or  international
           interest in trying to organize the fight for smallpox?

D.A. Henderson:  The international concerns about smallpox were there  very,
           very strongly  because  all  travelers  were  obliged  to  carry
           certificates indicating  they've  been  successfully  vaccinated
           within the preceding  three  years.  Just  about  every  country
           including our own enforced this. If you weren't  vaccinated  you
           wouldn't get admitted or they might vaccinate you on  the  spot.
           There was a great concern about importations of smallpox.

      It was in 1958, just about a year later after I  had  seen  the  cases
           that the vice-minister of the Soviet Union proposed to the World
           Health Assembly that  they  undertake  a  program  to  eradicate
           smallpox. That was the year the Soviets came back in to  the  UN
           family. They'd withdrawn because of the Korean War and they were
           - they just come back. So the proposal,  they  looked  at  this,
           delegates at the assembly looked at this and they really  wanted
           to be helpful and encouraged the Soviets this time.  So  a  year
           later they approved a program to eradicate smallpox.

      The only thing  was  that  at  -  that  same  time  the  World  Health
           Organization was deeply  involved  in  a  program  to  eradicate
           malaria. And fully a third of all staff were  involved  in  that
           and all the spare money they could get together because  it  was
           very expensive, very costly. The  idea  of  undertaking  another
           eradication program was really not the intent  of  the  director
           general. In fact the only thing he could do is say,  "Fine."  He
           really gave it very little money and a few  countries  then  did
           some vaccinating and tried to get rid of smallpox. They did make
           some progress in this but it basically was going anywhere.  That
           was the beginning. It was 1959 when they decided that they would
           undertake a global program but it really was not  anything  that
           was happening. It was seriously, it was not until 1966 that they
           really took it seriously.

Paul O'Grady:    What was the  attitude  of  the  United  States  government
           towards this program that it seemed to have gotten some  impetus
           from the Soviet Union? Was  there  any  political  peculiarities
           about that?

D.A. Henderson:  There, clearly was an element of Cold War competition.  The
           US was heavily supporting the malaria eradication program,  both
           through  the  organization  very  heavily  and  through   direct
           bilateral donations to the  countries.  So  the  US,  you  could
           almost say, owned the malaria eradication program. The  Russians
           had no program at that point that they could say the same  thing
           about. So, in a way they came in with  this  smallpox  and  said
           look, we got rid of it in the Soviet Union  back  in  the  1930s
           when our vaccine wasn't so good,  when  health  conditions  were
           poor, where personnel were not well trained and we  got  rid  of
           it. So, why can't the rest of the world get rid of it?

      So that's where they came in and then put after 1959,  every  year  at
           the World Health Assembly they would really  give  the  director
           general a very hard time. Why aren't you putting more money into
           the smallpox program? Why do you favor the malaria program?  And
           so that went on as a continuing piece. The  US  really  took  no
           notice of it. It's really what it amounted to  until  really  it
           came up to 1965 when a change came for the US.

Paul O'Grady:    Which was?

D.A. Henderson:  Well, in 1965 - I'll go back  a  little  bit,  1961,  Merck
           Sharp &amp;amp; Dome, at  that  time,  was  introducing  a  new  measles
           vaccine. It caused a lot of fever in children.  So  in  the  US,
           they were using it giving the measles vaccine and they gave them
           some immune globulin at the same time so that they wouldn't have
           so many reactions to the measles vaccine illness, if  you  will.
           This made little practical sense if you went to Africa. The idea
           of  doing  these  two  together  and  made  life  a   lot   more
           complicated. You really could not do large scale vaccination and
           try to preserve the immune globulin and deal with two  shots  to
           get this. So they undertook studies in Upper Volta, Benin. I  am
           sorry Upper Volta  is  the  place  where  they  were  doing  the
           country.

      They did x number of children, 150 -200, kids reacted very well.  They
           were no complications. Then they asked -  the  country  minister
           said, could you give - do it for all kids  under  six  years  of
           age. So they gave them a vaccine enough for that. Then there was
           an organization,  French  organization  that  had  a  number  of
           countries and he said, could we do it  for  six  countries  now.
           USAID said, "Okay, we will  do  it  for  six  countries."  Well,
           things couldn't go very well with six. I won't go  into  all  of
           the complications but we got drawn in at that time to evaluating
           it. I sent one person over to evaluate. It was a disaster.

      Well, not to be deterred they decided  we  are  now  going  to  do  11
           countries. We need from you, 11 people for six  months  each  to
           help get the program started in  each  country.  I  thought,  we
           can't do that. Really, it's - a good segment  of  my  staff  and
           signing people over for  6  months  at  a  stretch  is,  without
           families and what have you, this is tough.  So  I  thought,  you
           know, I really have to work  with  AID,  we  really  got  to  be
           responsive to them. I didn't know what to do. So I decided,  all
           right, let's put together a proposal that we would say is  sound
           from this public health standpoint.

      Why was the measles proposal bad? Well, they were  going  to  give  it
           for just four years and then stop.  In  other  words  AID  would
           support it for four years and they  expected  the  countries  to
           continue. It cost a $1.75 a dose. The countries couldn't  afford
           $0.10 a dose for yellow fever  vaccine.  So  this  is  not  good
           public health practice. To start a program, get the hopes of the
           public up and then drop it. This  is  terrible  way  to  do  it.
           Smallpox had vaccine however, cost  a  penny  a  dose.  So  they
           proposed the idea, well, suppose you take this  whole  block  of
           countries, 18  countries  and  suppose  you  give,  do  smallpox
           vaccination -

Paul O'Grady:    And you talk about West Africa?

D.A. Henderson:  This is west, West and Central Africa as  well  called  it.
           And so we do 18 countries.  You  give  smallpox  and  develop  a
           smallpox program there. We could get rid  of  smallpox  in  that
           whole area, they could then  -  would  have  as  an  established
           program for vaccination. They could continue it easily when that
           only cost them a cent a dose  in  vaccinating  newborns  and  so
           forth. Then if they want to have measles vaccine added  and  the
           ministers think this is a good idea, we would be happy  to  give
           measles vaccine at the same time,  but  we  can't  eradicate  it
           because measles spreads too easily. We couldn't get rid  of  it,
           but at least the countries would have to think through was  this
           a good idea to do this with measles vaccine as well.

      Well, I think the cost - what USAID expected to spend was  about  five
           or $6 million. The proposal we submitted was about $35  million.
           So, I knew it can be turned  down.  But  on  the  other  hand  I
           thought it was going to be a point of departure for  discussion.
           I didn't know where we were going to find any sort of compromise
           on this. They just, their demands were  so  great  that  it  was
           impossible. So I set it up through channels, through the surgeon
           general and very shortly USAID turned  it  down.  We  were  just
           debating along about autumn what we  would  do  subsequently  on
           this.

Paul O'Grady:    And we are still in 1965?

D.A. Henderson:  This is 1965, when all of a sudden we got information  that
           the president had decided to  approve  the  program,  the  whole
           program.  This  shook  everybody.  My  boss  Alex  Langmere  was
           absolutely beside of himself.  As  I  told  him  they  were  not
           supposed to accept it, that was - but the president was  looking
           for an  initiative  which  would  be  something  that  he  could
           publicize that the US was contributing  to  a  UN  International
           Cooperation  Year.  There  were  several  proposals  that   went
           forward. This I had  no  idea  was  even  being  considered  and
           suddenly AID was told by the White House,  fund  it.  All  of  a
           sudden, we are told, all of a sudden we have got 18 programs  to
           set up in the West and  Central  Africa.  We  had  never  run  a
           program outside the United States at all.

Paul O'Grady:    So you guys have been  faced  with  a  tremendous  manpower
           problem?

D.A. Henderson:  Well, we would need about 54 people. That we are  going  to
           have to recruit. AID said that it probably would be - you  can't
           do this under three years. They agreed finally to fund  it  then
           on November. They felt we could get it in three years.  I  said,
           no. This is wrong. It's just got too much of a delay. How  about
           13 months? We will have the people  over  there  in  January  of
           1967.

       They  thought  it  was  almost  impossible.  You've  got   individual
           agreements what  every  country.  You  have  got  to  order  the
           vaccine, you have got to put on training programs, you've got to
           recruit all the people. We did. Recruited the people, we got the
           vaccine ordered. We got vehicles. We  had  to  use  US  American
           vehicles. There weren't  any  in  all  of  these  countries.  No
           maintenance, no repair, so  we  had  to  set  up  workshops  and
           everything else, to train our people to be mechanics. We had  to
           lay out plans for all of the countries to get everything  signed
           and we did.

Paul O'Grady:    Let's talk of, just for a second, about  the  attitudes  of
           the countries  involved.  What  was  the  interaction  with  the
           governments like?

D.A. Henderson:  Well, in November as soon as  this  was  approved,  I  went
           over with a consultant that I had who, Warren  Winkelstein,  who
           was a good epidemiologist and spoke French,  another  person  by
           the name of Dr. Henry Gelfand. The three of us went and  visited
           each of the different countries. Fortunately a  number  of  them
           were having a meeting, so we could present it to all of them  at
           one time.

      They were enthusiastic. Why were they enthusiastic?  More  -  most  of
           them, more because of the measles vaccine because this is a very
           - in Africa, this is a very deadly disease.  It's  10-15%  death
           rate. The French speaking countries by and large had  done  some
           pretty good vaccination with pretty good  vaccine.  The  English
           speaking countries  had  a  lot  of  smallpox.  They  were  more
           enthusiastic about the smallpox. But they were getting both  and
           they were really very  enthusiastic.  We  were  coming  up  with
           vehicles. We were coming up with vaccines  and  consultant  help
           but not a lot of people. It was by and large one or  two  people
           or advisors to be assigned to most of the countries with  a  few
           more in Nigeria.

Paul O'Grady:    And how about the Americans that  were  going  to  go  over
           there as part of this program? Let's talk  a  little  bit  about
           their attitude?

D.A. Henderson:  Well, the Americans who were going over there, a number  of
           the people I - some of them I had known. Basically called up and
           said, we have got this coming up, are you free, or would you  be
           interested, people, contemporaries and so forth. I had a  couple
           of people  who  are  already  serving  in  CDC  and  took  them.
           Basically it was almost word of mouth advertising because  there
           just wasn't very much time, and contact with people  at  schools
           of medicine and other places,  infectious  disease  people  that
           might know of people interested in this. People -  the  word  of
           mouth, by word of mouth they learned about this and my goodness,
           we were able to recruit enough, so that we were  able  to  begin
           the training program in July of 1966.

Paul O'Grady:    And people were on the ground?

D.A. Henderson:  Well, they had to finish up the training.  We  had  to  get
           all the agreements signed. I think we got all of them in  to  16
           of the 18 countries. We managed to put two, postpone two, but we
           had 16 of them by January of 1967. Meanwhile, there is a  little
           problem. There was a debate coming up in the Assembly in May  of
           1966. So this is only like about 6-7 months after this  approval
           for the whole West African program had come through.

Paul O'Grady:    Debate in the United Nations Assembly?

D.A. Henderson:  Debate in the World Health Assembly?

Paul O'Grady:    Okay.

D.A. Henderson:  Every year the ministers  of  health  convene  in  May,  in
           Geneva to look at issues of health. So they  were  debating  the
           question of  going  with  an  intensified  program  of  smallpox
           eradication with  a  budget  of  $2.4  million  a  year  and  an
           objective to complete that within 10 years. The director general
           Marcelino Candau, a very capable  Brazilian  knew  that  it  was
           impossible to  eradicate  it.  He  felt  you  had  to  vaccinate
           everybody in the world and he was a Brazilian and he  knew  that
           there were tribes in the Amazon that hadn't been found. Or  were
           just recently found or  that  sort  of  thing.  So  he  knew  it
           couldn't be done.

      There were a number of  countries  that  were  very  doubtful  of  the
           concept of eradication at all because they were having  so  much
           trouble in malaria eradication. There were  others  who  thought
           this was far too ambitious for an organization  like  WHO  which
           is, where it's not, except for the malaria really it hadn't  run
           programs or really coordinated  that  way  operationally  health
           programs. So it came to a debate in the assembly. The US had, as
           I said, been very quiet before this really in taking a  position
           but at this assembly they were going  to  take  a  vote  finally
           because it was very controversial, whether they  went  ahead  or
           didn't go ahead. One of the strong arguments was well, the US is
           already committed, funds and personnel for - to take care of  18
           countries.

      So that's a big start on this whole thing and after two o three  days,
           three days debate, they did vote. They had  about  58  votes  to
           start the program and it passed by just two votes.  It  was  the
           closest vote they have ever had in the  World  Health  Assembly.
           The director general was furious and felt that the assembly  had
           committed the World Health Organization to a  program  which  is
           going to fail. It would bring the  organization  into  disrepute
           and question the credibility of  public  health  and  the  World
           Health Organization. He blamed the US for this.

      Well, in a way, it was true. If the US had not done this  crazy  thing
           in West and Central Africa  that  almost  certainly  the  voting
           would not have gone as it did. So he was  blaming  the  US.  He,
           then, called the surgeon general in the US and said  I  want  an
           American to run the program because when it goes down,  when  it
           fails, I want it to be seen that there is an American there  and
           the US is really responsible for this dreadful  thing  that  you
           have launched the World Health Organization into and the  person
           I want is Henderson. Well, I was associated, of course, with the
           West African program of having gotten involved with starting  it
           and so forth.

      So I got called to Washington and I was told I was being  assigned  to
           be head of  the  World  Health  Organization's  Global  Smallpox
           Program. I declined. I said, we  are  just  starting  this  West
           African program. We have just - there is a huge amount  of  work
           and we have just barely started. The $2.4 million we got to  go,
           we had programs in 50  countries.  We  don't  even  have  enough
           money, $2.4 million won't even buy the vaccine we need.  Trying,
           I  had  some  experience  in  working  with  the  World   Health
           Organization and they really were  not  working  well  together.
           Each of the six regional offices were sort of wholly independent
           and trying to coordinate them was a terribly job. So I  said,  I
           really can't do it.  I,  you  know,  I  think  this  is  a  very
           difficult task. I really, I think if we do a good  job  in  West
           Africa, we are going to show what can be done. Maybe  that  will
           encourage the other countries but that's, I think, where I ought
           to stay.

Paul O'Grady:    Was this conversation going on between you and the  surgeon
           general?

D.A. Henderson:  Yes. So I declined. He said - I  said,  you  do  not  -  we
           don't order people in the public health service to go from place
           to place. That we - we talk about career opportunities,  and  so
           forth and so on. It's not like the military services.  He  said,
           "Well, this is your career opportunity." I said, "And suppose  I
           decline." He said, "You are fired." I said, "You  are  serious."
           He said, "I am very serious. I will tell you what, make a  deal.
           You go for 18 months and if at any time during  that  18  months
           you really feel it won't go, just send me a telegram,  just  put
           now and I will pull you out." So, I headed for Geneva to head up
           the Global Program.

      We left in October to go to Geneva, get a house. Wife and three  kids,
           plus left half of our household goods in the storage because  we
           knew we would be back pretty soon. Took over  a  program,  which
           was a  global  program.  This  provided  for  headquarter  staff
           eventually of nine of us. It never  got  bigger  than  that.  So
           there were five medical  officers,  two  admin  officers  and  a
           couple of secretaries. That was our total staff.

Paul O'Grady:    Let me ask you about your own mindset at  this  point.  You
           had mentioned the problems with the  measles  program  and  that
           malaria eradication had been problematic. Were you optimistic at
           this point about - at least with respect  to  the  West  African
           piece of the puzzle? You  were  optimistic  about  eradication's
           success?

D.A.  Henderson:   This  is  a  good  question  as  to  whether  you   would
           characterize what I felt is optimistic. My feeling  was  it  was
           doable but without a full appreciation of  everything,  all  the
           problems we would encounter. I must say  because  as  I  thought
           back on it, had I any idea of all the  problems  that  we  would
           face, I would have not been  optimistic.  You  can't  anticipate
           civil wars, floods, masses of refugees, one thing after  another
           and bureaucratic  blockage  of  things,  countries  refusing  to
           participate. All of the difficulties you can have with this, but
           fortunately I was innocent of the problems, these problems  that
           you would encounter or we couldn't anticipate,  obviously,  most
           of these.

      It was the fact we had a good vaccine and the vaccine we knew and  I'd
           worked, we had done some studies at CDC while I was in charge of
           the surveillance program, showing the vaccine was very good. You
           could  get  virtually  a  100  percent  takes,  using  a  proper
           technique. We had jet injectors that  we  had  worked  with  and
           perfected these with the inventor in the  US  Army  so  that  we
           could add jet injectors that could vaccinate a  1000  people  an
           hour. They looked - we looked optimistic that we could do a  lot
           of vaccination with them. So that, we had  a  good  vaccine,  we
           knew something about smallpox. You know  that  -  we  knew  that
           there were a  number  of  countries,  developing  countries  who
           didn't seem to have any cases but the reporting was so bad that,
           little did we know that many of them just weren't reporting it.

      But we just - we really didn't have an idea but we thought there  were
           large countries, free of the disease, certainly the US  was  and
           Canada was. Certainly there must be others  that  were  involved
           too. So it was a feeling of  technically  this  was  doable  but
           without an appreciation that experience would provide as to just
           how difficult the problem would be.

Paul O'Grady:    Let's take you to - take  you  back  to  Geneva.  You  have
           arrived, you had your family there and when  did  you  start  to
           realize that these challenges were going to present themselves?

D.A. Henderson:  We quickly found that we  had  problems.  Within  just  the
           first couple of years, we ran into a number of problems.

Paul O'Grady:    Can you - ?

D.A. Henderson:  The West African program basically,  Don  Millar  who  took
           over from me, who had been my chief of my smallpox unit  before.
           He was running it and he had a good administrative  officer  and
           he had some very good people in the field. My feeling  was  that
           they had to run that themselves and the only thing we could help
           them with, which they needed was some local costs.  I  think  we
           gave them a  couple  of  $100,000  a  year  to  permit  in  some
           countries, purchase a vaccine, gasoline and a few other  things,
           they couldn't get it, legally with their USAID funds. Other than
           that, they were on their own.

      So we worked at the world and saw well,  we  got,  two  countries  are
           sitting rather at the far end. One is Indonesia,  the  other  is
           Brazil. Now at that time, South America appeared to be  free  of
           smallpox except for Brazil. They had done  vaccination  programs
           in the other countries  and  one  way  or  another,  with  their
           infrastructure, not perfect but  they  managed  to  get  rid  of
           smallpox. That of course was encouraging. But if we got  rid  of
           it in Brazil then they would be far away from endemic areas  and
           indeed they could be basically the funds  that  we  are  putting
           into a Brazilian program could be withdrawn and  we  put  it  in
           other areas like Asia or Africa.

      Similarly with Indonesia, Indonesia sitting off where we are here  and
           the countries nearby are free of smallpox.  So  the  chances  of
           smallpox being imported into Indonesia,  if  we  got  that  free
           would be small and therefore the  limited  amount  of  funds  we
           could use have, we could then transfer that to  other  countries
           and at least make a start in trying to get rid of  the  smallpox
           with the limited funds we had. So, that was the strategy.

      We almost immediately found we had a  vaccine  problem.  The  Russians
           had pledged 25 million doses a year and we had no idea how  much
           vaccine we would really need. Most of the countries  were  doing
           some vaccination. The disease was  so  severe,  it  was  such  a
           problem that at least they had to vaccinate in  the  big  cities
           simply because of civil disorder, with too much of this epidemic
           smallpox, it is destabilizing. So in all countries we are  doing
           some vaccination and what we had - we made the  assumption  that
           most of them, already have vaccine and we have  got  25  million
           from the Soviet Union. US is covering all the vaccine  needs  in
           their 18 countries, later 20 countries. So we got to be alright,
           but we - I thought we need to have some way to determine whether
           the vaccine is really, really potent, really good.

      So, I went to the Netherlands and asked if they would  help  in  doing
           testing the vaccine, vaccine quality of the production that  was
           there and then we went to Connaught Laboratories in  Canada  and
           they agreed to do that as well. So we began getting  samples  of
           vaccine from the different countries and they began testing  it.
           Five percent of it was potent and stable. Five percent  met  the
           international standards.

      So we had a problem almost immediately. We couldn't afford to buy  the
           vaccine. So I made a decision, we won't buy any vaccine. We  are
           going to have  to  develop  -  improve  the  vaccine  production
           facilities that are out  there.  We  called  a  meeting  of  the
           vaccine producers from several major  laboratories.  From  Wyeth
           Laboratories in the US, they were the producer  here,  they  had
           one Lister Institute in London, where  Netherlands  were  there,
           Soviet Union were there. I think that was it.  We  brought  them
           together and  we  talked  about  vaccination  and  developing  a
           standard manual. Every country was using where they were  making
           a vaccine they were using all sorts of different techniques.

      So let's get what we think is the best  way  to  do  it  in  a  simple
           manual that I can  understand.  Then  let  us  then  help  these
           countries improve their vaccine. We will, then work with  UNICEF
           to try to get them to provide some machines so that  they  could
           freeze dry the vaccine and we would use some of the people  from
           these consultant laboratories that we had brought together to go
           out and train and help develop the vaccine. That's what we did.

      The vaccine quality began to pickup. It was  by  about  1972,  we  had
           more than 80 percent of the vaccine was being  produced  in  the
           endemic countries themselves and it was good quality. So we were
           immediately  involved  in  trying  to  solve  just  the  vaccine
           problem. How to administer the vaccine was the second problem.

      The problem was this. You have a vaccine which is a very, has a  vial,
           it's in a vial with about 0.25 milliliters  of  fluid.  That  is
           reconstituted. You have one vial that has dried  powder  of  the
           vaccine, another which has a quarter of a  milliliter  of  fluid
           which is a very small amount. To use a vaccine, you have to  put
           the liquid into the dry powder and mix it up. Then  you  had  to
           put it on the arm.  The  way  they  did  this  in  most  of  the
           developing countries was take like a glass rod, dip  it  in  and
           then put it on the - dip the rod against the arm, tip it against
           the arm and a little drop would be there. Then by and large what
           they did was scratch through the vaccine. They had a  number  of
           scratches through the vaccine, it was  an  old  technique  which
           goes back more than a 100 years.

      In the US we did  a  little  bit  differently  but  it  was  the  same
           principle but it was important that the US did it this way. They
           took and took a needle and they put the drop back on the arm and
           then they gently pushed the virus through the skin and the  idea
           was that if you got it just through the skin it  will  grow  and
           produce something. If you push too hard you will  get  bleeding.
           If the bleeding occurs then it washes out the virus.  You  don't
           push hard enough, it doesn't  go  into  the  skin,  and  so  the
           vaccination fails.


      Wyeth laboratories was developing a new device which I  visited  Wyeth
           laboratories because  it  was  the  question  of  improving  our
           vaccine production capabilities in the other countries and  they
           showed me this wonderful device which they developed.  A  little
           needle about - well, tube about so long. There  are  two  little
           prongs on the end. They called it a bifurcated or  sort  of  two
           fork needle. The idea was you put the needle  into  the  vaccine
           and you just withdrew it. Between those two  prong,  the  little
           bit of vaccine would be held and then they thought you press  it
           through the skin.

      In this way the amount of vaccine you could get from a  vial  was  100
           doses rather than 25 doses. Well, I looked at it and I know  how
           much trouble we had had in  trying  to  teach  them  to  medical
           students how to vaccinate because they were forever not  getting
           it quite - not enough pressure to break the skin. So  it  wasn't
           growing and then a number of them are getting a  little  bit  of
           drop of blood and that was thought to be bad. So  I  raised  the
           question of well, suppose that we take a needle and just hold it
           like this and poke it like this, we called it multiple puncture.
           Instead of  scratching  or  pressing  it  through,  do  multiple
           puncture. You are going to  get  bleeding.  So  let's  see  what
           happens.

      So we tried a few of these, they all got  very  successful  takes.  We
           took it to the field into Kenya and Egypt and  did  several  100
           children and we did it very vigorously. There was a little  drop
           of blood on everyone. Every single one of them  was  successful.
           So this was incredible. All of a sudden we were  going  to  have
           four times as much vaccine than we thought  we  had  or  we  are
           getting, with these wonderful needles. The needles cost  us,  we
           shortened them up a little bit and make  them  cheaper  than  we
           made them out of a stainless steel virtually.  We  could  get  a
           thousand of them for $5. You could boil them and reuse them  and
           we ran through about a 120 vaccinations perfectly  good.  So  we
           had needles very inexpensively.

      We had a vaccine and suddenly we had four times as much vaccine as  we
           thought we had. Then it was a matter of bringing those into play
           in the different countries and this went very rapidly. So it was
           another development, right at the beginning which  made  a  huge
           difference. It was a  crazy  little  thing.  Now  the  important
           thing, I think was is that the - the inventor of this, a man  by
           the name of Ben Rubin received a one time, to tell  you,  what's
           called the John Scott Medal of the City of Philadelphia for  the
           best, most important invention of a particular year. Here he was
           getting this and it had gone back - the award goes back  to  the
           1700s. Marconi has received it, Edison has received it so forth.
           He said, "This is the most insignificant patent or  invention  I
           have ever made," and he said, "And here I am receiving the  John
           Scott medal." And it was - it just was like inventing the safety
           pin. It was so incredible.

      So we began using that, we had - introduced the jet injector for  West
           Africa but very soon we said,  for  this  price  we  don't  have
           problems in mechanic to repair  or  what  have  you.  It's  very
           inexpensive, much less expensive than a bio - than jet injector.
           So pretty soon the bifurcated needles took over the whole of the
           world in terms of vaccination. Well, we had a couple of the very
           early problems that we had. There were many more.

Paul O'Grady:    So tell me how the smallpox program  moved  into  Asia  and
           East Africa?

D.A. Henderson:  Well, West Africa, I want to go back to  the  West  African
           program which began in '67 and they managed to record their last
           case in 1971. Well, ahead of schedule and under budget. Not  too
           many programs come through like that. Meanwhile, I had a man  in
           East Africa and he was working with the people in the  different
           countries and helping them  and  strengthening  what  they  were
           doing, a Russian, Ivan Ladnyi and they began to make  very  good
           progress. We, from WHO, began  supporting  Central  Africa,  not
           Central Africa, but Sudan  and  Zaire  are  two  huge  countries
           across the middle. This was frightfully  difficult  but  we  had
           some very good people, incredible people.  Some  national,  some
           internationals and they began to make a good deal of progress.

      Brazil, I got  back  to  say  Brazil  became  free  in  '71.  We  had,
           Indonesia was a bit of struggle but they became free by 1972. In
           fact the whole of  Africa,  was  free  of  smallpox  except  for
           Ethiopia. The whole of Africa was free of smallpox by the summer
           of 1973. We were only six years into the  program  and  here  we
           were with a good piece of the world free now of smallpox. So, in
           the summer of 1973, we were down to - just five  countries  that
           had  smallpox,  just  five.  It  was  India,  Pakistan,   Nepal,
           Bangladesh in Asia and Ethiopia.

      When you looked at India and that group - that bunch of  countries,  I
           think the population then was maybe about 700  million.  So  you
           look at it and you say, only four  countries  in  Asia  but  700
           million people is, at that time, almost three times the size  of
           United States. So it was not a small undertaking  to  deal  with
           that. Meanwhile in Ethiopia, they were doing a malaria  program.
           They did not want to see a smallpox program. So, the Minister of
           Health refused to even have  me  go  and  talk  with  him  about
           starting a program. So nothing had happened in Ethiopia  at  all
           on smallpox, up until late 1970 before I  managed  to  get  into
           Ethiopia and lay out a  plan  and  by  various  devices  working
           through the emperor to get approval to get started in Ethiopia.

      So we came in the summer of '73. We had programs in all the  countries
           and we were very optimistic that now we are on our way. The  big
           problem, frankly, at that time was India. Huge country, a number
           of people talked about India being like the native, like we talk
           about cholera being the home or India being the home of cholera.
           There are some who said, well, India with very dense population,
           particular climate  and  so  forth.  They  must  have  something
           special  here  that  maybe  is  the  home  for  smallpox.   Very
           difficult, you will never get rid of  it  there.  That  was  the
           general discussion that was going on.  We  weren't  making  much
           progress.

      India had started a program back in 1962, not so long after the  first
           World Health Assembly heads said, well, let's do an  eradication
           program. By the time they got to 1973  it  really,  they'd  made
           progress some of the southern states of India but most of India,
           they were still recording as much smallpox  as  they've  had  11
           years before. They were discouraged and really,  not  sure  they
           would continue. There was a lot of discussion about it. It was a
           problem saying we really have to keep going. They agreed  to  do
           so and this was the earlier 70s. They agreed to  keep  on  going
           but then we met and sort of the late spring of '73 and we  said,
           we have got to do something different.

Paul O'Grady:    Who's meeting?

D.A. Henderson:  In India, well  the  strategy  that  we  had  had  was  not
           working. They had done a lot of  vaccinating.  They  were  doing
           mass vaccination all the time, they were then  beginning  to  do
           what we called surveillance and containment. Really getting much
           better reporting and when a report came  from  a  village,  they
           would go out, send a team out. Try to vaccinate and control  the
           outbreak. It didn't seem to be working and there was a  still  a
           lot of cases and we were - they were  not  making  progress.  So
           that spring we decided what we needed to do was find  the  cases
           more quickly. Find them before they became outbreaks.

      So the decision was made  that  we  try  to  undertake  a  village  by
           village search throughout the whole of India in  10  days  time.
           Mobilize the health services for an  intensive  10  day  search.
           With this we were - would employ about a 120,000 people. And the
           idea initially was to go to selected parts of the village  in  a
           particular pattern to try and find cases and see what you  could
           turn up. There was a lot of planning. A lot of organization went
           on. We got Bill Foege from CDC, was sent over. I had  asked  for
           more help. They sent over a couple of people but India is a  big
           place and we have a very  cracked  team  of  international  from
           France, from Czechoslovakia, from Soviet Union, but not  a  lot,
           we were very few.

      So the first search was completed in October  in  this  one  state  of
           India. We were normally getting about 500  cases  a  week.  That
           first search was completed and they  recorded  10000  new  cases
           found, 10000 new cases. This wasn't even the high point  of  the
           season. This was really at the - almost the  beginning  of  when
           the seasonal increase occurred. Oh my gosh!  This  is  far,  far
           worse than we had ever imagined. Well, it was  even  worse  than
           that, because it wasn't several weeks later  I  found  that  the
           search teams had not done a great job and  they  really  reached
           only half of the villages. So it was probably twice  as  bad  as
           bad as I thought it was.

      They repeated the search in another two months and  they  got  better.
           By about the third search they got into  the  point  where  they
           would do house to house. We actually had a  team  following  and
           doing a sample number of the villages to make sure that they had
           really reached at least 80 percent of the houses.  So  we  began
           gradually to mobilize this tremendous force. It took 8  tons  of
           paper for one search. We began getting  more  cases.  The  cases
           were increasing. The problems were that of mobilizing the staff,
           of supervision, quality control. It was a really tough  job.  We
           went on and through the summer of 1974, when at  that  time  the
           smallpox goes down to its low as  points.  Some  of  -  smallpox
           transmits best like measles in the winter. Measles is  a  winter
           disease, smallpox is the same.

      Whatever it is, whether it's being dryer air and cooler air that  does
           it we don't really know  all  the  answers.  But  certainly  the
           summer months are where it gets to  the  lowest  point.  So  the
           summers and the states, northern states where  this  almost  all
           the smallpox was, the summers are terrible, 120  degrees.  There
           is not - limited amount of electricity and there is certainly no
           air conditioning. We were bringing in a lot of people who are on
           3-month volunteer stints  with  their  Indian  colleagues.  That
           summer it was murder. We brought them together,  once  a  month,
           looked at what they had done. Reports, we viewed all  of  these.
           We had no cell phones, we  had  no  telephones.  There  were  no
           computers. I mean, this was all done by hand. They'd come in for
           a weekend. We'd come in for work for a day and then they had one
           day of rest.

Paul O'Grady:    Can you identify a turning point in the Indian experience?

D.A. Henderson:  Yeah, I will come to that.  At  the  moment,  there  was  a
           turning point but a strange one. We worked through  '74  but  we
           got started going into late '74. The seasonal  pick  up,  picked
           up. There were more cases than ever, it was really a  going  and
           there were several longer term trends in the  disease  in  India
           and this was a little [1:03:18 inaudible]  with  a  longer  term
           trend. It was on its way up and we were not having that much  of
           an effect.

      However, by the time we got to around February, we realized  that  the
           search system was in place. That we had some  very  good  people
           supervising this and in fact I even remember  the  time  it  was
           with, Bill Foege, the  two  of  us  were  looking  at  this  and
           wondering now, where were we at this point in time  and  that  -
           but as Bill said, I am not sure I am going to put out a weekly -
           putting out, I guess a bi-weekly report and the curve was  going
           up and he said, the only thing I can  do  that's  optimistic  is
           turn it upside down. But we felt at that time, secretly that  we
           are on our way and they got worse.

      It got worse for the bad time in a way and  a  good  time  in  others.
           India detonated a nuclear device. They had people, press  coming
           from all over. The theme of all of the coverage,  news  coverage
           was India detonates nuclear  device,  smallpox  -  their  health
           system is so bad that they are the world's primary  country  for
           smallpox. So here is this advanced country with  such  primitive
           health facilities that it's epidemic for smallpox.  This  got  a
           lot of interest. The Indian government  was  not  pleased.  They
           were very upset and they began making more resources  available.
           Higher levels in government began paying  attention  to  it  and
           they assigned to the program, from  the  Indian  side,  four  of
           their very best people to work with four of our central  people.
           We call it the central appraisal team.

      Well, we got over that and for India at least, when  we  came  to  the
           end of the last cases in May of 1975, we thought we had the last
           case. There was a beggar woman out on a railway platform in  the
           far eastern part of India going into a whole area  and  she  had
           infected a bunch of people going after. We had no idea what  was
           going on.

      By that time  by  October,  the  Minister  of  Health  and  the  Prime
           Minister were very excited about this.  We  were  not  confident
           that we got rid of smallpox. October 5 - August 15th is  India's
           Independence Day. They were determined to announce that this was
           India's Independence Day and it's freedom from smallpox for  its
           first time in history. I would say we were chewing nails at that
           time, thinking, oh my gosh! If they have more cases,  you  know,
           the press coverage and these people don't  know  what  they  are
           doing, oh god. It would have been awful, that was the last case.

      Meanwhile, Bangladesh was  going  through  tragedy  after  tragedy  of
           flood and famine  and  we  had  an  exhausted  group  of  really
           fighting to get rid of it in Bangladesh which is  a  story  unto
           itself. So, on August 15th, the Director General and  I,  headed
           for Bangladesh. They only had I don't know, something like maybe
           80 villages infected at that point. It was  just  really  coming
           way down and we felt, my gosh! I think we are going to have - be
           rid of this bad disease for all the world. It was a very  severe
           time for smallpox. That would have been in.

      So we are on our way to the airport and got the word, all flights  are
           canceled. The President of the country, the really the  founding
           father of the country, Mujibur  Rahman,  had  been  assassinated
           along with his entire family. Martial  law  had  been  declared.
           Troops were moving  to  the  border.  Floods  of  refugees  were
           expected. We thought, oh my god, once more, but for some reason,
           the international group, was laid low. They worked locally, they
           kept out of the way and the expected civil war that was expected
           to erupt immediately did not. They went back to work and finally
           in October of '75 it was all done in Asia.

      Then we were left with Ethiopia  and  Somalia,  subsequently  Somalia.
           Well, if you like to hear the rest of the  story  I  can  go  on
           Ethiopia but Ethiopia is a huge country. People look at the  map
           and they say oh, it's about the same size as  Georgia,  but  not
           so. It's equivalent to all of the states on the eastern seaboard
           of the United States in area. It's  huge.  There  are  very  few
           roads or where there are roads or even roads you can  drive  on.
           It's estimated I think that, two-thirds of the population  lived
           more than one day's walk from any accessible road, at least  one
           day.

      We had just - the government had only, I think,  2000  health  workers
           in the whole country. For  a  while  we  were  working  with  20
           Ethiopian sanitarians, 14 US peace  corps,  about  six  Japanese
           peace corps and some Austrian peace corps  and  some  volunteers
           who kind of wandered in. Anybody who wanted to work, we put them
           to work and paid them the Ethiopian per diem which if you didn't
           [1:09:59 inaudible] high on the hog on that one, I can tell you.
           Then as they were making progress, slowly but it was  difficult.
           Some of the - first time we ran  into  a  huge  area  where  the
           people fought against vaccination. They didn't want it.

      Trying to solve that problem, took us  some  doing  but  finally  they
           wanted malaria drugs and we could give them  malaria  drugs.  We
           got malaria drugs to give them,  provided  they  got  vaccinated
           first. So they got vaccinated first and then got the drugs.  Not
           the way you like to run a program but that was the only  way  we
           were going to stop the disease. It was a  less  severe  decision
           than let's say in  Asia.  So  there  is  less  motivation,  less
           concern on the part of government.

      Well, we got all of a sudden the emperor Haile Selassie was in  charge
           and had been there you know, as emperor for a  long  time.  They
           had a coup, military coup. Marxist  military  group  took  over.
           Civil war broke out, so there was fighting in different parts of
           the country. The emperor was, I don't really know what  happened
           to him. I think he was killed. Then it was the  US  Peace  Corps
           had to pull out as did the other groups. A number of the embassy
           people pulled out and for a quite a  period  of  time  the  only
           people allowed by the military to go outside of Addis Ababa were
           the smallpox group.

      We had some pretty very good people, particularly our person  who  was
           the real leader of the program, he was a Brazilian fellow by the
           name of Ciro de Quadros. He  had  a  charm  and  an  ability  to
           persuade that was legendary. That's why we had permission to  go
           outside the country but that wasn't much fun because they were -
           we had to go to many  of  the  provinces  with  military  escort
           because it was too dangerous. So  they  fought  through  all  of
           that. It was really horrendous and then they came to a point.

      Finally we got additional people in,  and  then  finally  the  surgeon
           general of the United States came up with a  contribution  of  a
           million dollars for us to get  three  helicopters  to  transport
           people. It was so big. That made a huge difference. Well, one of
           them was shot down, one of them getting up there - I don't know,
           we don't know what reason went into like Kenya. Another one  was
           hit with - they threw a hand grenade at it. They were a pair  of
           those, of those and they took one for the - we had to get at one
           of them with a hostage and they were captured and we had  ransom
           notes which I've still got a copy of the request for ransom from
           the people dictated by the rebels,  written  by  the  helicopter
           pilot. While he was captured took the vaccine and  got  all  the
           rebels vaccinated, so took care of that, he was thinking all the
           time.

      Finally we got to this place in Dimo, a little  village  way  down  in
           the desert, last  case.  I  flew  down.  We  thought  we  got  a
           television crew down there, film this and we did and got  a  lot
           of footage of Dimo, crazy little village sitting in  the  middle
           of a desert. We had a hard time even finding it with  the  -  by
           helicopter, you couldn't spot at great distance.  We  went  back
           and we waited and they searched. Nothing, nothing.  It  went  on
           for eight weeks. We were about ready to make a statement at  the
           press, we are done. There was a report came in of two  cases  in
           Somalia right next door.

      Well to make a long story short, the Somali government, even  for  the
           all the discussions we had had with them, had been hiding cases.
           They knew they had smallpox.  They  were  admitting  them  to  a
           hospital in a sort of secret ward, nobody knew about. They  were
           trying to stop it but because they were  embarrassed,  the  only
           country with smallpox. They hated the Ethiopians and they  hated
           the thought that Ethiopia was free of smallpox. They refused  to
           believe that they were free.

      This went on and as they would let our people come in but  they  would
           let them go out beyond the main city  of  Mogadishu.  The  cases
           kept occurring but they are having  trouble  finding  out  where
           were they coming from, in other words, who was  infecting  them.
           Finally, there was a great discussion  about  this  and  one  of
           them, the turning points, I  think  it  was  that  a  couple  of
           turning points had happened. One being  they  captured  a  Dutch
           adviser who we had working with Ethiopians. He was kidnapped, if
           you will, with his team and vehicle and taken  to  Mogadishu.  I
           think we had eight or nine of these and then the UN commissioner
           would intervene and talk to president and minister.

      This fellow Bert van Ramshorst, finally they took him. He has  to  see
           the minister. So he spent, sat down with the minister and pretty
           well, persuaded him that Ethiopia was free of smallpox and  that
           there was a problem and that the - WHO would be willing to  help
           and so forth and so on. He made a quite a persuasive pitch here.
           Meanwhile, Assistant Director General, Ivon Lodney indicated  he
           would want to come down and visit the city of Mogadishu  at  the
           capital and meet with the Minister.  The  Director  General  was
           threatening to do the same and I think the pressure was on.

      Then they began to loosen up. So from then until this was about  March
           of '77 and the number of cases, I recall are  about  3000  cases
           finally that they had troubles because  they  had  nomad  groups
           moving all over the desert area, couldn't  find  them.  Smallpox
           kept spreading and you couldn't vaccinate them. It  wasn't  that
           they would resist vaccination, you couldn't find them. Then  the
           great problem was, come November, was the Hajj. Somalia is right
           near Saudi Arabia. Many people come from Somalia to  Mecca.  All
           we could imagine were people and they would  come  from  through
           Somalia from other countries, all we could imagine  was  can  we
           possibly have at this time, one of these groups  infected  going
           into Mecca and spreading  it  among  hundreds  of  thousands  of
           people and watching smallpox go like this.

      So there was a frantic effort in terms of - they flew in vehicles,  so
           we had more mobility and flew in all sorts  of  people  and  the
           government declared a national emergency and it went all out. On
           October 26, 1977, Ali Maow Maalin, a cook  23-year-old  was  the
           last case of smallpox. That was the end of the smallpox. We  had
           to spend two more years working in the countries to make sure it
           was really the last one.

Paul O'Grady:    How  did  you  find  out  about  that  last  case,  do  you
           remember?

D.A. Henderson:  Oh, yeah. They had brought in some people at this point  in
           time. They were moving people to an isolation camp to make  sure
           that they would be held. There was two kids who were brought  in
           by a vehicle from outside one of the program vehicles  and  they
           brought them in and they stopped  at  the  hospital  to  inquire
           about where the camp was. Ali Maalin was a cook at the hospital.
           He was supposed to have been vaccinated but he  wasn't.  He  had
           been a vaccinator, in fact but he hadn't been vaccinated. How we
           went wrong, - he got in the vehicle, rode for about  10  minutes
           till they got to the isolation camp. He got out and he came down
           with smallpox.

      Well, he came down with a rash, and as often the case the last is  the
           worst. He was admitted in a hospital and  diagnosed  as  chicken
           pox. Finally, they had  discharged  him  with  a  mild  case  of
           chicken pox and it was one of the other people, friends of  his,
           who said,  I  don't  think  this  is  chicken  pox.  It  wasn't,
           smallpox. He was a very popular guy and he had contact with  all
           sorts of people. So, there were everything  from  roadblocks  to
           all night searches throughout Mogadishu to goodness knows  what,
           trying to find possible other cases, but it was the last.

Paul O'Grady:    So do you have any final thoughts,  anything  you  want  to
           share about your experience with over the course of the years in
           the program?

D.A. Henderson:  Well, I think there were several things about  the  program
           that were very special and that is that we came together, people
           from across the world worked together very well. I  worked  very
           closely with the Russians. It was during the darkest days of the
           Cold War. Totally cooperative, we shared all  sort  of  problems
           and they had some things that needed to be corrected and I  flew
           to Moscow. We talked it over, they corrected them. We had people
           working across borders from one country to another. We  had  mix
           of nationalities out there. What was perfectly clear was that if
           we had a goal, we had leadership at all  these  levels  that  it
           became a very unique situation. Bridges were built such  as  you
           can't imagine. It formed the basis for going  on  from  smallpox
           and we really convened a meeting  and  before  the  program  was
           over, to say, the vaccination has been so  inexpensive.  We  can
           vaccinate  so  many  people  in  a  day,   so   effectively   so
           efficiently. We should be doing more of the smallpox vaccine.

      This  was  an  international  meeting  we  held  and  from  that  came
           recommendations for an expanded program for immunization,  which
           was finally accepted by the World Health Assembly in 1974,  even
           before the end of smallpox. The idea was to add other  vaccines,
           diphtheria, whooping cough, tetanus, the  DPT  vaccine,  measles
           and polio and add this to smallpox. That was  adopted  and  then
           UNICEF got behind it and rotary got behind the  polio  side  and
           the goal was at that time to reach 80  percent  of  the  world's
           children by 1990 with these six vaccines. At the  beginning,  we
           estimated that at best about 10  percent  were  receiving  these
           vaccines. So we had cases of  tetanus  and  diphtheria.  Totally
           preventable diseases, whole wards full of whooping cough and  so
           forth and good vaccines out there, well, made it. So by 1990, 80
           percent of the world's  children  had  been  vaccinated  against
           these  six  diseases.  So  this  was  the  expanded  program  in
           immunization which  is  going  on,  became  in  due  course  the
           eradication of polio. It served to eradicate measles  throughout
           the western hemisphere. Measles was gone.

      We had so few cases of tetanus and diphtheria that it was  a  amazing,
           they were  exceptionally,  just  throughout  the  whole  of  the
           Americas, they developed reporting system which I think, at  the
           beginning we had 500 hospitals reporting once a month. The  last
           count I looked at the reporting, they had weekly reporting  from
           42000  sites  in  Latin  America.  People  just  -  it's  better
           reporting for these diseases than it is in the United States  of
           America. This is going on to develop the group that has convened
           here, have done all sorts of marvelous things and  out  of  this
           came a feeling  of  we've  done  this,  why  can't  we  take  on
           something else. They have done that with great success.

      So, if there is a real need for  an  international  organization  WHO,
           even though there is some of those like our President  Bush  who
           have not felt the need to work with other countries, this  could
           never have been done in the United States, it could  never  have
           done by a  few  countries,  it  had  to  have  an  international
           organization. It showed also how much you  can  do  if  we  have
           preventive medicine and public health vaccines. We were  dealing
           with 10 to 15 million cases of smallpox a year, 2 million deaths
           a year and 10 years later we have zero cases, and  zero  deaths.
           This is pretty dramatic.

      Now you  are  seeing  similar  things  happening  with  measles.  Very
           dramatic changes and now we are talking  about  with  the  Gates
           Foundation supporting a lot of  things,  why  can't  we  go  and
           tackle malaria in a different way. Why aren't we doing  research
           to get better vaccine for tuberculosis,  why  don't  we  have  a
           vaccine against malaria? It's opened  up,  it's  begun  a  whole
           revolution in prevention which is really something to see. Today
           or last couple of days, we have been hearing  reports  of,  now,
           how many different fronts it's moving on very rapidly and really
           rethinking all of this.

      It has, I think, built bridges in the  international  field  that  you
           can't build in agriculture or education.  Those  are  political.
           Agriculture, for obvious reasons,  even  education,  it  becomes
           quite political. With the health side, you really just don't get
           into political issues. It's amazing, you don't and thus  it  has
           built relationships in ways that are really quite unique  across
           the Americas which I have spent more time with  recently.  There
           have been in other areas as well. They had days  of  tranquility
           in the  Americas,  where  in  the  fighting  in  Nicaragua.  The
           agreement was they would stop fighting for  two  days  and  they
           would and the vaccination team to go out. This has  happened  in
           Afghanistan, days of tranquility. So that even the rebel  groups
           could be approached and could be helpful.

      So we got to Peru in the end of polio in the Americas, the last  cases
           were in the area called the Shining Path, where the Shining Path
           was. They destroyed hospitals, they destroyed schools what  have
           you. What the people really behind the scenes, Ciro  de  Quadros
           who was the head of immunization for the Americas had  met  with
           the commanders of the Shining Path and talked it through and got
           commitments from them, not to harm  the  health  workers.  Well,
           they went through and this is what the health workers are doing.
           Guess  what,  they  searched  this  whole  area  which  was   so
           dangerous, it was a problem for the military to go into.

      So there, it's something that I think is unique about health here  and
           something which gives you great encouragement  for  the  future.
           Thus, I really feel  quite,  I  feel  like  we  have  a  made  a
           difference well  beyond  smallpox  eradication.  I  think,  well
           smallpox eradication, I think has been the first  step.  We  are
           now moving on well beyond that into many more exciting things.

Paul  O'Grady:     Great.  DA  Henderson,  thank  you  very  much  for  this
           interview.

D.A. Henderson:  Yeah, you are very welcome.

[End of audio 1:29:16]
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