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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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                    <text>CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

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Smallpox Eradication: Memories and Milestones

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10/26/2007

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Thirty years ago, on October 26, 1977, a Somali man, Ali Maow Maalin, was
diagnosed with a case of smallpox. A World Health Organization (WHO) team led
by Jason S. Weisfeld, MD, MPH, from CDC, and Karl Markvart from
Czechoslovakia, conducted a surveillance and containment program that confirmed
this to be the last case of endemic smallpox in the world. This historic
achievement was possible only through the persistent efforts of thousands of local
health workers who identified people with smallpox and vaccinated around them to
prevent the spread. International leadership was vital, but without the dedication of
local and national governments, eradication would not have been possible.

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Today in CDC Connects we look back at that historic achievement as we talk with
key scientists involved in the program to eradicate smallpox. Read on for memories
from Weisfeld and also D.A. Henderson, Don Millar, Bill Foege, and Mike Lane.
Words from Weisfeld: “I Had the Premonition I Was Being Given a Major
Responsibility”

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Ali Maow Maalin holds the
dubious distinction of being
diagnosed with the last case of
endemic smallpox in the world.

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Who were you and why were you in Somalia?

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At the time of my assignment in Somalia, I was a Career Development officer with
CDC having completed two years of EIS, more than a year seconded to WHO for
Smallpox Eradication Programmes in India and Bangladesh, a Preventive Medicine
residency and an MPH at Harvard. I felt very privileged to be selected for the first
group of Westerners invited to work in Somalia and had begun work in various
endemic areas of central Somalia in May 1977.

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What was the smallpox situation in Somalia?
Although national authorities had attempted to conceal active transmission prior to
our arrival, intense surveillance and active public participation soon revealed that
smallpox was being transmitted in many areas of southern and central Somalia.
By the time of the last case in October 1977, we had interrupted all of the known
chains of transmission and there was heightened anticipation that we would soon
identify any last remaining cases.

Epidemiologist Jason Weisfeld
(front) attends a meeting along
with epidemiologists from
Holland and Egypt. Such
monthly staff meetings were
held during the Bangladesh
smallpox eradication program to
monitor progress. The world
came together to rid mankind of
this horrible viral disease. Photo
by PHIL

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How did the last case become infected? How was his case identified?

Documentum
Ali Maow Maalin was a 23-year-old cook at the Merca Hospital along the coast of
southern Somalia when he became infected. He had volunteered for the local
Smallpox Eradication Programme staff and had been immunized, but no one
checked his vaccination site and his subsequent illness revealed that he must not
have had a successful immunization and was not protected.

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One evening, after office hours, two cases of smallpox were brought to the hospital
and Ali was selected to drive with them in a closed Land Cruiser with the windows
closed and the air conditioning running to the local team leader’s house. We
estimated that Ali was probably exposed to these cases for a maximum of five
minute—but that was sufficient.
When Ali became symptomatic with fever and rash, his history of being immunized
against smallpox led the local hospital staff to assume that he had chickenpox. He

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Smallpox is a serious,
contagious and sometimes fatal
infectious disease. The name
smallpox is derived from the
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refers to the raised bumps that

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�CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

was hospitalized briefly but then discharged to the small room he rented near the
hospital. When being visited by one of the male nurses from the hospital, it was
suspected that he might have smallpox and the team leader reported the suspect
case to the Ministry of Health in Mogadishu.

appear on the face and body of
an infected person. Photo by
PHIL

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What action did finding Ali precipitate?

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Upon confirming the diagnosis, the National Smallpox Eradication
Programme initiated a major response. Dr. Karl Markvart, a Czech
colleague, and I were requested to transfer immediately to Merca and
assume responsibility for the management of the outbreak. We had the full
support of additional international and national staff as well as the local police
and Party authorities.
Our first priority was to organize surveillance within Merca Town and to
establish working relationships with local authorities and community groups to
immunize the entire population of the town and surrounding areas. We
established check-points at all entrances to the town and local staff
kept log books of who arrived, and departed, and their immunization
status. Vaccinators were stationed at these check-points and immunized
anyone who had not been recently immunized.
A vaccinator travels by camel during a
smallpox outbreak in Niger. Dedicated
smallpox pioneers worked long hours
and traversed rugged terrain to
provide immunizations. Photo by PHIL

What was your role?
I was requested to identify all contacts and then to immunize them and their
families as well as to maintain rash-and-fever surveillance on all of them every two
days for six weeks. By establishing a close, personal relationship with Ali in his
containment camp, I was eventually able to identify 161 contacts and their close
family members. With the assistance of a local team of dedicated health workers
and a fleet of motorcycles, we were able to maintain close surveillance for the
required six-week period.
What were your thoughts when it was realized that this was the last case of
smallpox?
As mentioned, even prior to the identification of Ali’s case, most of the Programme
staff were quite aware that we had interrupted almost all of the remaining chains of
transmission within Somalia. Special attention was being given to ensuring that an
outbreak among a nomadic group near Merca was prevented from spreading to
non-protected populations. So, when I was asked to shift to Merca to assist with
Ali’s case, I had the premonition that I was being given a major responsibility and
would need to be especially rigorous in whatever ways I could assist. In addition to
coordinating the immunization and surveillance of contacts, I also helped Karl
supervising night-time immunizations of the town population.

Both this mother and her child
bore the scars after surviving
smallpox. The symptoms of
smallpox begin with a high fever,
head and body aches, and
sometimes vomiting. A rash
follows that spreads to raised
bumps and pus-filled blisters
that crust, scab and fall off after
about three weeks, leaving a
pitted scar. Photo by PHIL

Of course, some of us were not very confident that this WAS the very last
endemic case until sometime after Ali’s recovery. We still feared ongoing
transmission in inaccessible areas of Ethiopia. But this never came to pass.
Many people have described their experience in the smallpox
eradication effort as a career-changing moment. How did your
experience affect your career?

The Smallpox Eradication and
Measles Control Programs, West
Africa, 1968. boys in West Africa while
standing in front of a poster
announcing Smallpox Eradication and
Measles Control Programs. Note the
use of jet guns. Photo by PHIL

I had been attracted to a career in public health with CDC because of the
opportunities to work internationally and my early assignments with the WHO
Smallpox Eradication Programmes in India, Bangladesh and Somalia
provided very gratifying experiences. Through working closely with dedicated
national staff and communities, I was motivated to continue working in
International Health activities for almost all of my career. And since retiring
from CDC, I have been very fortunate to be able to continue serving
internationally as well as being able to share my experience with students at
Harvard, Boston University, Tufts and Dartmouth.

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�CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

What has become of Ali? Did he become involved with EPI?

Use of boats such as the ones seen
here, was essential to the success of
the smallpox eradication program, as
well as general public health
maintenance of Bangladeshi
communities. General essential items
such as food, and medicinal goods
were transported via the waterways,
for many of the towns affected by
illnesses which included smallpox,
were situated along rivers throughout
the country. Photo by PHIL

When I visited Somalia in the mid-1990s for UNICEF, I tracked down Ali in a
small roadside town near Merca. He was working as an untrained drug seller
in a local shop and we had a wonderful reunion over a proverbial cup of
sweet tea. Subsequently, I understand that he joined the national Polio
Eradication Programme— perhaps fulfilling his earlier dream of helping out
with Smallpox Eradication. Wouldn’t it be wonderful if he could participate in a
celebration of a special anniversary of the last endemic case or Global
Smallpox Eradication at some time in the future?
Success Seemed “Inevitable” to Former CDC Director Bill Foege
One of the major events in the globalization of CDC was the USAID/CDC
Smallpox Eradication Measles Control Program in 21 countries of West and
Central Africa from 1966–1972. Among the key participants was former CDC
Director, William Foege, MD, MPH.

Foege is an epidemiologist who became chief of CDC’s Smallpox Eradication
Program; he was appointed director of the CDC in 1977. He joined the Carter
Center as executive director in 1986 and became a senior adviser to the Bill
and Melinda Gates Foundation in 1999, where he is now emeritus as a fellow.
His contribution to smallpox eradication is legendary. He worked as a medical
missionary in Eastern Nigeria, where he developed a surveillance and
containment strategy that changed the worldwide approach to smallpox
vaccination and eventually led to the disease's eradication in the 1970s. He
provides this reflection on his thoughts concerning eradication back then.

This 1980 photo shows three former
directors of the Global Smallpox
Eradication Program as they read the
good news that smallpox has been
eradicated on a global scale. Shown
(left to right) are J. Donad Millar, MD,
(director 1966–1970); William H.
Foege, MD, (director 1970–1973); and
J. Michael Lane, MD, (director 1973–
1981). Photo by PHIL

“It is interesting about thoughts at the time of eradication. Mine seem to have
been much different than most. For me the high point was when I saw in my
mind that this could happen. All of our actions were simply carrying out the
plan and so I felt no surprise at the end. It seemed inevitable. I was content to
leave (India) before smallpox was gone because I had no doubt that it was on
track. Indeed, it always seemed to me that surprise was inappropriate and it
indicated a lack of faith in the idea. I don't think that resonates with many,
however.”
For related stories on Foege and smallpox see Calling the Shots; and A
Lifetime Spent on the War on Disease. For more on the former CDC director
see CDC History: Focus on Foege.
More on the Mission: Don Millar Calls it “Special Era”

Millar, a WHO Central Assessment
Officer from CDC shows off his
successful smallpox vaccination scar
in the village in the Bhojpur District,
Bihar, India. Photo by PHIL

Indeed, many had doubts says Don Millar MD, who retired from CDC as
Director of NIOSH. “But it was a very special era. I have more doubts that we
could do it today than back then. The 21 African countries where we were
working were recently independent of colonialism so there were things in
place that worked, line railroad lines and telegraphs. Some of that
infrastructure is just no longer in place now. But beyond that, it was the
people involved. Dave Sencer saw to it that the World Health Organization
(WHO) had what it needed to get the job done, both medical and non-medical
American resources. He always found a way to get things done.”

“And in India Bill Foege was the leader and Bill Watson was the chief
administrator. In Bangladesh it was Stan Foster and Andy Agle. In Geneva, D.
A. Henderson was key; no one else could have done what he did. These
people were just remarkable. And it was a special era. We were still in the post World War II mentality, not yet
disenchanted by capitulating in Vietnam. There were lots of young Americans who believed in smallpox eradication,
who had the can do mentality, the Peace Corps mentality, the desire to work toward Utopia. Our people were our
resources and our power.”

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�CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

“Today there is nowhere near that optimism of getting things done globally.
We were naïve and innocent perhaps, but it worked.”
When CDC first established a smallpox surveillance unit, Millar was put in
charge. He says for him the greatest thrill was his work in West Africa.
“Nothing else in my career has been as fulfilling as the four years I worked on
smallpox eradication in West Africa.”

David Sencer, MD, former CDC
Director, Sencer snaps a photo in
Ghana where he was attending a
celebration marking the 25th million
smallpox and measles vaccination.
The umbrellas are part of the
gathering of traditional chieftains which
is called durbar. Read more about
Sencer.

Another highlight was in Somalia, he says, when the International
Commission certified Somalia free of smallpox two years after the last case.
“I had some rigorous assignments in Somalia which was engaged in civil war
with Ethiopia. But it was thrilling. Even when we went to the most remote
locations, out in the bush, the nomads would be yelling and cheering. They all
knew about smallpox eradication. The program had penetrated so far—that
was a real thrill.”

It’s an accomplishment with impressive global significance, says Millar.
“Smallpox is still the only disease in the world eliminated by human intent.
Now back then, I didn’t realize that smallpox could still be a threat today. I’m
talking about biological terrorists. Mike Lane actually conceived of that possibility, he recognized even back then
that human evil could be the worst threat to the eradication of smallpox. I don’t think most people back then gave
any thought to how vulnerable we could be to bioterrorism. But it could happen. We’ve had decades now of no one
being vaccinated. It’s a tinder box.”
“Back then we were euphoric about human nature,” says Millar. “It pains me how
fragile it is. But I am so grateful to have been part of it, of the smallpox eradication
program.”
These days Millar is “living in the woods, doing consulting for occupational and
environmental health, and trying to motivate myself to write.” He has new twin
grandchildren, a “wonderful distraction,” and says he also does a lot of string–bass
playing which is very “soul restorative.”
His memories of CDC’s involvement in smallpox eradication are good ones. On the
day the announcement came in that India was certified smallpox free, Millar was
serving as acting CDC director. “I got to call a meeting and talk about it. And I
remember I said, well we have put two deities out of business!”
He was talking about Shopona, whom the Yoruba of West Africa identified as the
god whose wrath created smallpox, and Shitala, a deity worshipped in India as the
goddess of smallpox.
DA Henderson Called Smallpox an “Ideal Disease to Eradicate”

This double image includes an
illustration of a smallpox victim
contrasted with a family
receiving smallpox
vaccinations. In this case, the
Nigerian public health worker is
using a bifurcated needle, which
ultimately replaced the ped-o-jet
as the most efficient vaccine
delivery system. Photo by Kathy
Nellis

There were gods and goddesses of smallpox because people were so afraid of the
disease, says D.A. Henderson, MD. “No other disease has deities and temples
erected to it.”
But because people were so terrified of smallpox, they were eager to stop it. “We
enlisted the help of the local people. We trained them to identify it and report it. And
the vaccine was really amazing. You needed only one satisfactory inoculation to
protect someone for up to 10 years. Even more amazing, scientists found a way to
make it into a powdered, freeze-dried form. You could put it in a vial and it would
remain fully potent for a month, even at high temperatures, which made it ideal for
the tropical areas. A vaccinator could just stick a vial in his pocket and go out into
the field, no worries about refrigeration.”
Still Henderson had doubts about eradicating the disease from time to time. “But
we were all hopeful. Against such formidable obstacles, we had to wonder if we
could succeed. The confidence came in 1974, when things looked up in India. It’s a
huge country and there were a large number of cases and the government of India
had spent lots of money trying to eradicate polio. People were getting discouraged.
But then in 1973 we began a huge push to go village to village, house to house, in
a period of 10 days. Bill Foege and I were together in India then and I remember

This is a statue of Shapona, the
West African god of smallpox.
Smallpox was thought to be a
disease foisted upon humans
because of Shapona’s diving
displeasure. This figure is part of
CDC’s Global Health Odyssey
collection of artifacts. The
wooden figure is adorned with

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�CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

there were more cases of smallpox being reported than ever. It was because the
surveillance was so much better but it certainly made the epi curves look bad. But
we realized we were on our way and that if we could eradicate smallpox in India,
we could do it globally.”

monkey skulls, cowrie shells and
nails. Photo by Jim Gathany

It was Henderson who tied smallpox eradication to the measles immunization program which was already underway
in Africa at the time. Henderson saw the combination of the two campaigns, measles and smallpox, as “politically
desirable, humanely urgent, and economically feasible.” Within a week after CDC’s Smallpox Eradication Program
was created, he was in Geneva to consult officials at the World Health Organization (WHO). And eventually he
became chief of WHO’s smallpox eradication program.
Smallpox was actually an ideal disease to eradicate, explains Henderson. “It only
existed in man, not in animals. People who were infected either recovered and
became immune or they died. So we just had to stop the spread from human to
human. We saw the virus as a chain. If we could just break the links we could
prevent many more cases.”
The work was tiring and often dangerous he says. “There was civil war and
insecurity. In Ethiopia the government would not allow any foreigners to go outside
the capital city except those of us working in smallpox. We had their confidence.
Still, workers were fired upon and sometimes kidnapped. UN officers would have to
persuade the guerillas to release the public health workers.”
It was also difficult technologically, Henderson recalls. “A phone call from Geneva
to New Delhi could take hours to put through and it was very expensive to call.
Today you have computers and cell phones and even GPS which would have been
great to keep track of the teams.”

Alexander Langmuir, MD, MPH,
(sitting) was the father of
infectious disease epidemiology.
He began the EIS in 1951 and
was CDC's chief epidemiologist
from 1949 to 1970. He is talking
to Donald A. Henderson, MD,
MPH, who eventually became
chief of WHO’s smallpox
eradication program. Photo by
PHIL

For Henderson, it was a wonderful and significant experience. “May 8, 1980 was
an exciting day. The World Health Assembly held a special session to announce
the eradication of smallpox and the recommendation to stop vaccinations
everywhere, because they were no longer needed. That was a defining moment,
but it really was the end. It was what we had worked for, for years, but ironically it
was also kind of a let-down. We were used to working in the field with so many
wonderful people, sharing meals and sharing problems, sharing a real camaraderie, and developing deep
friendships. We were like soldiers in the battlefield but now the enemy was no more and we realized we would likely
not see these people, these disease warriors again. The joy was in the trip rather than in the arrival.”
The program would never have succeeded had it not been under the banner of
WHO, says Henderson. “The collaborative international effort was what was so
important. Working as the head of the program in WHO, I could meet with ministers
in various countries and talk openly and get cooperation. I don’t think one country
could have achieved anything like this.”
J. Michael Lane Recalls Major Breakthrough with Surveillance/Containment
It was an amazing global effort, says Mike Lane, MD. “The international community
just worked together and did it. Smallpox was eradicated in Chad during a major
civil war. It was eradicated in Indonesia during secessionist efforts.” Success was
achieved in country after country, despite the challenges. “People just laid aside
their differences to work on smallpox because it was really so important.”

This 1975 photo shows a
volunteer smallpox eradication
team member in the process of
vaccinating a child in a
makeshift tent in a bastee, an
impoverished
environment. Photo by PHIL

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�CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

Another reason for the global success was conceptual, says Lane. “Bill Foege
figured out that mass immunization was not the way to go. Instead he said we
should focus on surveillance, and on finding infected people and immunizing their
immediate contacts. Surveillance/containment was a major breakthrough.” Foege
called the idea eradication escalation and Lane quickly nicknamed it “E-squared.”
Lane, a French speaker, worked in the French–speaking African countries and in
Liberia, Sierra Leone, and Guinea. “It was a thrill to watch the curve go down in
West Africa much more quickly than we expected. There was a sudden dramatic
decline which was extremely satisfying.”
Lane was director of the smallpox program at CDC at the time the last case was
found. “We were all nervous about Somalia and Ethiopia. We had to go out and
talk to village and community leaders to find cases. This was difficult in these two
countries, where the last cases were, because the tribes were so fragmented
because of the terrain. The roads were poor and communication was difficult.
When the last case was announced there were cynics among us. How could we
know for sure, when the population was so spread out? We crossed our fingers
and held our breath as surveillance continued. But smallpox was really gone!”
That had global significance beyond the health consequences, explains Lane.
“Back in the 1950s and 1960s smallpox was a major deterrent to international
travel and commerce. Whenever a ship came into Manhattan, no passengers could
disembark and no cargo could be unloaded until inspectors went on board to look
for possible to check for possible smallpox cases. It was an expensive and
cumbersome process. And global travelers had to show international certificates of
vaccination against smallpox. Eradication removed those bureaucratic roadblocks.”

The worldwide eradication of
this dreaded disease was due to
the Smallpox Eradication
Campaign of the late 1960s and
1970s. Watch and listen to the
seminar presented on the 30th
anniversary of the eradication of
smallpox, including appearances
by Jason Weisfeld and fellow
smallpox eradicators Bill Foege,
DA Henderson, Don Millar, and
Bill Griggs. It will be showing
continuously today (Friday,
October 26, 2007) at the
Smallpox Eradication Exhibit in
the lobby of the Visitors Center,
Tom Harkin Global
Communications Center, Roybal
Campus. Photo by PHIL

Lane was also the leading person in getting the US to stop smallpox vaccination as
routine in 1972. The risk of importation at that point was far less than the risk of severe adverse reactions to
vaccine. He retired right before 9/11 but returned to public health to provide training and later took up a “third career”
helping pharmaceutical companies improve smallpox vaccine. “It’s been fun and interesting work.”
Hear the Smallpox Pioneers!
Watch and listen to the seminar
presented on the 30th
anniversary of the eradication of
smallpox, including appearances
by Jason Weisfeld and fellow
smallpox eradicators Bill Foege,
DA Henderson, Don Millar, and
Bill Griggs. It will be showing
from 1-3 pm and 3-5 pm on
Friday, October 26, 2007, at the
Smallpox Eradication Exhibit in
the lobby of the Visitors Center,
Tom Harkin Global
Communications Center, Roybal
Campus. This seminar will be
archived on IPTV beginning
October 30, 2007.

In the years since smallpox was eradicated, all known stocks of smallpox have
been destroyed, except the stocks at the CDC and the Russian State Research
Center of Virology and Biotechnology VECTOR in Koltsovo, where a regiment of
troops guards it. Under such tight control, smallpox would, it was thought, never
be let out again.
“I’m not a believer in the re-occurrence of smallpox,” says Lane. “I think
bioterrorism in this case is a political hoax. But I am grateful that we have rebuilt
our vaccine supply and our capacity to make vaccine.”
It’s a scourge none of these dedicated public health pioneers ever want to see
again.
This Inside Story by CDC Connects reporter Kathy Nellis with help from former
CDC Director Dave Sencer, MD. For more on Sencer and smallpox eradication
efforts. See Smallpox Pioneers Share Public Health History.

Visit CDC’s Smallpox Home page to find out more about efforts to protect the public.
And read up on the Scourge that was Smallpox to learn more about the deadly disease that wiped out
civilizations and provoked this amazing global eradication effort.
CDC Connects welcomes:
Feedback – CDCConnectsFeedback@cdc.gov.
Letters to the Editor – CDC Connects Feedback.
Story Ideas – CDCConnectsStoryIdea@cdc.gov.
Blog Topic Suggestions – send to Connecting Conversations.

http://intranet.cdc.gov/ecp/insidestory/story.asp?contenttype=article&amp;chronicalID=0900f3ee80229489 (6 of 7)10/26/2007 1:17:29 PM

�CDC Connects: Smallpox Eradication: Memories and Milestones, 10/26/2007

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Table of Contents

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HHS Intranet

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